Development and Characterization of Innovative Multidrug Nanoformulation for Cardiac Therapy

Review Nanoscience & Nanotechnology

Concepts on Smart Nano-Based Drug Delivery System

Shweta Rai et al.

Summary: Nanomedicine, a branch of healthcare, utilizes smart nano-based drug delivery systems for cell-specific drug delivery, showing great potential in various applications.

RECENT PATENTS ON NANOTECHNOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Therapeutic Peptides to Treat Myocardial Ischemia-Reperfusion Injury

Carlota Fernandez Rico et al.

Summary: Cardiovascular diseases, especially acute myocardial infarction, are the leading cause of mortality worldwide. Although revascularization procedures have been effective in reducing infarct size, they can also cause ischemia-reperfusion injury. There is an urgent need for new cardioprotective strategies to address this issue, given the increasing prevalence rates of risk factors such as aging, diabetes, and obesity.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Chemistry, Multidisciplinary

Cholinergic Neuron Targeting Nanosystem Delivering Hybrid Peptide for Combinatorial Mitochondrial Therapy in Alzheimer?s Disease

Kang Qian et al.

Summary: Mitochondrial dysfunction in Alzheimer's disease has shown promise as a therapeutic target. This study developed a multifunctional hybrid peptide HNSS and a suitable peptide delivery system to repair and protect mitochondria, leading to improved outcomes in disease-related damage.

ACS NANO (2022)

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Article Biology

Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

Wayne Mitchell et al.

Summary: Mitochondria play a key role in metabolic homeostasis and their dysfunction is associated with various diseases. This study analyzed the structure-activity relationship of tetrapeptide analogs with different aromatic side chain compositions and sequence registrations. The results showed that these analogs adopt compact reverse turn conformations when bound to membranes and exhibit differences in membrane interactions. The analogs had effects on membrane surface charge and were able to penetrate cells and target mitochondria without strict requirements for side chain composition or sequence register. The analog with tryptophan side chains showed the strongest impact on membrane properties and had the highest efficacy in cell culture studies.

ELIFE (2022)

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Article Chemistry, Physical

Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia

Fangyu Zhang et al.

Summary: Biohybrid microrobots consisting of nanoparticle-modified microalgae are constructed for active drug delivery in the lungs. In an acute bacterial pneumonia model, the microrobots effectively reduce bacterial burden and lessen animal mortality.

NATURE MATERIALS (2022)

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Article Multidisciplinary Sciences

Plasmonic gadolinium oxide nanomatryoshkas: bifunctional magnetic resonance imaging enhancers for photothermal cancer therapy

Luke Henderson et al.

Summary: This study reports a novel nanoparticle Gd2O3-NM, which is a multilayered nanoparticle structure capable of both magnetic resonance imaging (MRI) and photothermal therapy (PTT). Gd2O3-NM exhibits excellent stability and imaging performance, providing a new option for tumor treatment and diagnosis.

PNAS NEXUS (2022)

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Article Pharmacology & Pharmacy

New Nanoparticle Formulation for Cyclosporin A: In Vitro Assessment

Amandine Gendron et al.

Summary: Cyclosporin A (CsA) is an immunosuppressive molecule evaluated for ischemic heart diseases. A novel nanoformulation, SqCsA NPs, based on squalene and CsA has shown promising cardioprotective effects on cardiac cell lines, paving the way for potential medical applications.

PHARMACEUTICS (2021)

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Article Medicine, Research & Experimental

Peptide Szeto-Schiller 31 ameliorates doxorubicin-induced cardiotoxicity by inhibiting the activation of the p38 MAPK signaling pathway

Li Zhang et al.

Summary: This study demonstrated the cardioprotective effects of SS31 in ameliorating DOX-induced cardiotoxicity by reducing ROS levels, stabilizing mitochondrial membrane potential, and attenuating myocardial apoptosis and fibrosis. The inhibition of the p38 MAPK signaling pathway by SS31 was found to be associated with its cardioprotective function, highlighting the potential of SS31 as a drug for the treatment of DOX-induced cardiotoxicity.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Review Medicine, General & Internal

Designing Nanoparticle-based Drug Delivery Systems for Precision Medicine

Jianhua Yang et al.

Summary: Traditional drugs are facing challenges in solubility, absorption, and targeting in the era of precision medicine. With the support of nanotechnology, these issues were improved to some extent by modifying and fabricating various types of nanoparticles.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

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Review Medicine, General & Internal