Are NIRS-derived cerebral autoregulation and ABPopt values different between hemispheres in hypoxic-ischemic brain injury patients following cardiac arrest?

Review Geriatrics & Gerontology

Sepsis-Associated Encephalopathy: A Mini-Review of Inflammation in the Brain and Body

Hiroshi Ito et al.

Summary: Septic encephalopathy is an acute cerebral dysfunction that can occur in patients with sepsis, particularly affecting the hippocampus. The underlying mechanisms and treatment strategies for septic encephalopathy remain unclear, but there is hope for the development of clinically applicable therapies.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Review Critical Care Medicine

Determining Optimal Mean Arterial Pressure After Cardiac Arrest: A Systematic Review

Kiran J. K. Rikhraj et al.

Summary: Cerebral autoregulation monitoring to determine patient-specific optimal mean arterial pressure (MAP(OPT)) may enhance cerebral oxygen delivery in post-cardiac arrest patients. However, targeting MAP(OPT) does not consistently lead to improved neurological outcomes. Further research is needed to assess the clinical utility of MAP(OPT)-guided strategies in reducing secondary brain injury and improving neurological outcomes after return of spontaneous circulation (ROSC).

NEUROCRITICAL CARE (2021)

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Article Critical Care Medicine

Deviations from NIRS-derived optimal blood pressure are associated with worse outcomes after pediatric cardiac arrest

Matthew P. Kirschen et al.

Summary: Evaluating cerebrovascular autoregulation using near-infrared spectroscopy after pediatric cardiac arrest can help determine outcomes, where a greater burden of mean arterial pressure below optimal levels during the first 24 hours post-arrest is associated with unfavorable outcomes.

RESUSCITATION (2021)

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Review Physiology

REGULATION OF CEREBRAL BLOOD FLOWIN HUMANS: PHYSIOLOGY AND CLINICAL IMPLICATIONS OF AUTOREGULATION

Jurgen A. H. R. Claassen et al.

Summary: Brain function relies on a precise balance between metabolic demands, oxygen and nutrient delivery, and waste removal, which necessitates continuous regulation of cerebral blood flow. This regulation involves autoregulation, vascular reactivity to stimuli, neurovascular coupling, and endothelium-dependent responses. The focus of this review is primarily on autoregulation and its clinical implications.

PHYSIOLOGICAL REVIEWS (2021)

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Review Critical Care Medicine