Recently emerged omicron subvariant BF.7 and its R346T mutation in the RBD region reveal increased transmissibility and higher resistance to neutralization antibodies: need to understand more under the current scenario of rising cases in China and fe...

Letter Infectious Diseases

Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB

Ryuta Uraki et al.

LANCET INFECTIOUS DISEASES (2023)

Article Biochemistry & Molecular Biology

Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster

Chaitanya Kurhade et al.

Summary: This study reported on the neutralizing activities of a BA.5 bivalent booster against SARS-CoV-2 Omicron sublineages. The results showed that the BA.5 bivalent booster had good neutralizing efficacy against BA.4/5 but weaker efficacy against BA.2.75.2, BQ.1.1, and XBB.1. Previous infection significantly enhanced the strength and breadth of neutralization induced by the BA.5 bivalent booster. These data support a vaccine update strategy that matches newly emerged SARS-CoV-2 variants.

NATURE MEDICINE (2023)

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Article Microbiology

Enhanced neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2

Panke Qu et al.

Summary: The emergence of new Omicron subvariants, including BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2, has shown enhanced neutralization resistance against sera from vaccinated healthcare workers and COVID-19 patients. The mutations N460K, K444T, and F486S play a significant role in driving the increased neutralization resistance of these subvariants. These findings provide insights into the evolution of SARS-CoV-2 Omicron subvariants.

CELL HOST & MICROBE (2023)

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Article Multidisciplinary Sciences

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Rigel Suzuki et al.

Summary: The Omicron variant of SARS-CoV-2 has spread rapidly in several countries and has shown lower fusogenicity and attenuated pathogenicity compared to the Delta variant.

NATURE (2022)

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Article Multidisciplinary Sciences

Daily briefing: China’s COVID wave could kill one million people

Flora Graham

NATURE (2022)

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Article Multidisciplinary Sciences

Subvariant ‘soup’ may drive wave

Carissa Wong

NEW SCIENTIST (2022)

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Letter Surgery

The recently emerged BA.4 and BA.5 lineages of Omicron and their global health concerns amid the ongoing wave of COVID-19 pandemic - Correspondence

Ranjan K. Mohapatra et al.

INTERNATIONAL JOURNAL OF SURGERY (2022)

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Letter Infectious Diseases

The effect of cilgavimab and neutralisation by vaccine-induced antibodies in emerging SARS-CoV-2 BA.4 and BA.5 sublineages

Sara Y. Tartof et al.

LANCET INFECTIOUS DISEASES (2022)

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Article Public, Environmental & Occupational Health

The rapid emergence of multiple sublineages of Omicron (B.1.1.529) variant: Dynamic profiling via molecular phylogenetics and mutational landscape studies

Chiranjib Chakraborty et al.

Summary: This study analyzed the microevolution of the Omicron variant through molecular phylogenetics, divergence analysis, geographical distributions, frequency analysis, risk mutation analysis for antibody affinity, and mutational landscape analysis. The results revealed the divergence events and characteristics of various Omicron sublineages, including their cluster analyses, geographical distributions, and frequencies. The study also explored the mutational landscape and stability of the spike mutations in these sublineages. The findings contribute to a better understanding of the evolution and mutational properties of Omicron and may aid in the development of pan-coronavirus vaccines.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2022)

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Article Immunology

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

Fabian Schmidt et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Immunology

Complexity of the Basic Reproduction Number (R-0)

Paul L. Delamater et al.

EMERGING INFECTIOUS DISEASES (2019)

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Recently emerged omicron subvariant BF.7 and its R346T mutation in the RBD region reveal increased transmissibility and higher resistance to neutralization antibodies: need to understand more under the current scenario of rising cases in China and fears of driving a new wave of the COVID-19 pandemic

相关参考文献

Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB

Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster

Enhanced neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Daily briefing: China’s COVID wave could kill one million people

Subvariant ‘soup’ may drive wave

The recently emerged BA.4 and BA.5 lineages of Omicron and their global health concerns amid the ongoing wave of COVID-19 pandemic - Correspondence

The effect of cilgavimab and neutralisation by vaccine-induced antibodies in emerging SARS-CoV-2 BA.4 and BA.5 sublineages

The rapid emergence of multiple sublineages of Omicron (B.1.1.529) variant: Dynamic profiling via molecular phylogenetics and mutational landscape studies

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

Complexity of the Basic Reproduction Number (R-0)

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