An assessment of the reporting of tapering methods in antidepressant discontinuation trials using the TIDieR checklist

Editorial Material Medicine, General & Internal

Clinicians should withdraw antidepressants gradually, says NICE

Gareth Iacobucci

BMJ-BRITISH MEDICAL JOURNAL (2023)

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Article Primary Health Care

Withdrawing from SSRI antidepressants: advice for primary care

Emilia G. Palmer et al.

BRITISH JOURNAL OF GENERAL PRACTICE (2023)

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Review Pharmacology & Pharmacy

Clinical practice guideline recommendations on tapering and discontinuing antidepressants for depression: a systematic review

Anders Sorensen et al.

Summary: Major clinical practice guidelines provide limited support for clinicians in helping patients discontinue or taper antidepressants in terms of mitigating and managing withdrawal symptoms. The guidelines lack guidance on dose reductions, distinguishing withdrawal symptoms from relapse, and managing withdrawal symptoms. The overall quality of the guidelines is low.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2022)

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Article Ethics

Physician perspectives on placebo ethics

John Bliamptis et al.

Summary: The clinical use of placebos is controversial in the field of bioethics. While open-label placebos are seen as a more ethical alternative, physicians primarily focus on identifying and weighing the potential harms and benefits to patients when considering both non-disclosed and open-label placebos. Some participants believe that further research and training would be needed before they would be willing to use open-label placebos in their practice.

JOURNAL OF MEDICAL ETHICS (2022)

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Review Biochemistry & Molecular Biology

The relationship between dose and serotonin transporter occupancy of antidepressants-a systematic review

Anders Sorensen et al.

Summary: Brain imaging techniques allow visualization of SERT occupancy with antidepressant dose. Studies show a hyperbolic relationship between dose and occupancy, plateauing around 80% at minimum recommended dose. Limitations include fragmented data, small sample sizes, and short study durations. Future research should standardize methods and investigate lower dose occupancy.

MOLECULAR PSYCHIATRY (2022)

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Article Medicine, Research & Experimental

Promoting benzodiazepine cessation through an electronically-delivered patient self-management intervention (EMPOWER-ED): Randomized controlled trial protocol

Michael A. Cucciare et al.

Summary: This study aims to investigate whether the accessibility and effectiveness of a benzodiazepine cessation intervention can be improved through digitization and tailoring for specific populations.

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS (2022)

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Review Pharmacology & Pharmacy

Strategies to reduce use of antidepressants

Tony Kendrick

Summary: Antidepressant prescribing has been increasing year on year, but long-term use may lead to side effects and withdrawal symptoms. It is recommended that general practitioners avoid routine prescribing of antidepressants and actively review long-term use, suggesting slow tapering off for patients who are well. More research is needed to establish the incidence of withdrawal symptoms in patients coming off antidepressants and to test different tapering strategies through large randomised controlled trials.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

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Article Health Care Sciences & Services

Antidepressant medication to prevent depression relapse in primary care: the ANTLER RCT

Larisa Duffy et al.

Summary: The ANTIDepressants to prevent reLapse in dEpRession (ANTLER) trial investigated the clinical effectiveness and cost-effectiveness of antidepressant medication in preventing relapse in UK primary care. Results showed that discontinuation of long-term maintenance antidepressants in primary care increased the risk of relapse and withdrawal symptoms, but a substantial proportion of patients can discontinue antidepressants without relapse.

HEALTH TECHNOLOGY ASSESSMENT (2021)

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Article Pharmacology & Pharmacy

The role of Facebook groups in the management and raising of awareness of antidepressant withdrawal: is social media filling the void left by health services?

Edward White et al.

Summary: The study highlights the increasing reliance of individuals on peer-led Facebook groups to seek support in tapering off antidepressant medications, rather than relying on clinicians who prescribed the medications. The majority of group members are female, mainly from the United States, and their common reason for seeking help is failed clinician-led tapering.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2021)

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Article Health Care Sciences & Services

'Never change a winning team': GPs' perspectives on discontinuation of long-term antidepressants

Van Leeuwen Ellen et al.

Summary: The study found that discontinuation of long-term antidepressant use is a challenging and uncertain process for GPs, influenced by various factors. Some GPs perceive antidepressants as effective and safe, with their main concern being the risk of patient relapse. Others are influenced by factors such as patient health issues, patient requests, and new life events.

SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE (2021)

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Article Rehabilitation

Overview of Reviews Using the Template for Intervention Description and Replication (TIDieR) as a Measure of Trial Intervention Reporting Quality

Marcel P. Dijkers

Summary: The quality of intervention descriptions in health care research reports is generally low, with comparators being reported even more poorly. The use of supplemental digital content and customized versions of TIDieR for specific research domains may help improve the completeness of reporting.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2021)

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Editorial Material Primary Health Care

Tapering antidepressants: why do tens of thousands turn to Facebook groups for support?

Ed White

BRITISH JOURNAL OF GENERAL PRACTICE (2021)

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Review Pharmacology & Pharmacy

What I have learnt from helping thousands of people taper off antidepressants and other psychotropic medications

Adele Framer

Summary: Recent studies have confirmed that the incidence of antidepressant withdrawal syndrome is over 40%, yet there has been a lack of medical information on safely discontinuing these drugs. To address this gap, patients have developed a robust Internet-based subculture of peer support for tapering off psychiatric drugs and recovering from withdrawal syndrome over the past 25 years.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2021)

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Editorial Material Psychiatry

Antidepressant withdrawal - the tide is finally turning

Michael P. Hengartner et al.

EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES (2020)

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Review Endocrinology & Metabolism

Replicating group-based education interventions for the management of type 2 diabetes: a review of intervention reporting

K. Odgers-Jewell et al.

DIABETIC MEDICINE (2020)

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Article Psychiatry

Antidepressant treatment for primary care patients with depressive symptoms: Data from the diamond longitudinal cohort study

Sandra K. Davidson et al.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2020)

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Article Psychiatry

Prevention of Recurrence After Recovery From a Major Depressive Episode With Antidepressant Medication Alone or in Combination With Cognitive Behavioral Therapy Phase 2 of a 2-Phase Randomized Clinical Trial

Robert J. DeRubeis et al.

JAMA PSYCHIATRY (2020)

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Article Clinical Neurology

Open-Label placebo for the treatment of unipolar depression: Results from a randomized controlled trial

Uri Nitzan et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Review Psychology, Clinical

A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based?

James Davies et al.

ADDICTIVE BEHAVIORS (2019)

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News Item Medicine, General & Internal

NHS prescribed record number of antidepressants last year

Gareth Iacobucci

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Medicine, General & Internal

Helping people discontinue long-term antidepressants: views of health professionals in UK primary care

Hannah M. Bowers et al.

BMJ OPEN (2019)

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Review Medicine, General & Internal

Do pharmacy intervention reports adequately describe their interventions? A template for intervention description and replication analysis of reports included in a systematic review

Micheal de Barra et al.

BMJ OPEN (2019)

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Article Psychiatry

Tapering of SSRI treatment to mitigate withdrawal symptoms

Mark Abie Horowitz et al.

LANCET PSYCHIATRY (2019)

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Article Psychiatry

Effectiveness of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment versus their combination in prevention of depressive relapse or recurrence (DRD study): a three-group, multicentre, randomised controlled trial

Claudi L. H. Bockting et al.

LANCET PSYCHIATRY (2018)

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Article Psychiatry

Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial

Marloes J. Huijbers et al.

BRITISH JOURNAL OF PSYCHIATRY (2016)

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Article Medicine, General & Internal

Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial

Willem Kuyken et al.

LANCET (2015)

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Article Medicine, General & Internal

Process evaluation of complex interventions: Medical Research Council guidance

Graham F. Moore et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Article Medicine, General & Internal

Process evaluation of complex interventions: Medical Research Council guidance

Graham F. Moore et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Article Pharmacology & Pharmacy

Abrupt Discontinuation Compared With a 1-Week Taper Regimen in Depressed Outpatients Treated for 24 Weeks With Desvenlafaxine 50 mg/d

Arif Khan et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2014)

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Article Medicine, General & Internal

Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide

Tammy C. Hoffmann et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

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Article Psychiatry

Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression

Zindel V. Segal et al.

ARCHIVES OF GENERAL PSYCHIATRY (2010)

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Article Psychiatry

Time to Relapse After 6 and 12 Months' Treatment of Generalized Anxiety Disorder With Venlafaxine Extended Release

Karl Rickels et al.

ARCHIVES OF GENERAL PSYCHIATRY (2010)

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Article Psychology, Clinical

Duloxetine in the Prevention of Depressive Recurrences: A Randomized, Double-Blind, Placebo-Controlled Trial

David G. S. Perahia et al.

JOURNAL OF CLINICAL PSYCHIATRY (2009)

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Article Psychology, Clinical

Mindfulness-Based Cognitive Therapy to Prevent Relapse in Recurrent Depression

Willem Kuyken et al.

JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY (2008)

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Article Psychology, Clinical

The prevention of recurrent episodes of depression with venlafaxine for two years (PREVENT) study: Outcomes from the 2-year and combined maintenance phases

Martin B. Keller et al.

JOURNAL OF CLINICAL PSYCHIATRY (2007)

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Article Psychology, Clinical

Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT study

James H. Kocsis et al.

JOURNAL OF CLINICAL PSYCHIATRY (2007)

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Article Substance Abuse

Randomised controlled trial of two brief interventions against long-term benzodiazepine use: Outcome of intervention

N Heather et al.

ADDICTION RESEARCH & THEORY (2004)

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An assessment of the reporting of tapering methods in antidepressant discontinuation trials using the TIDieR checklist

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