Modeling the dynamics and control of rabies in dog population within and around Lagos, Nigeria

Rabies appeared in Nigeria in 1912 and the disease is endemic in many states of the country including Lagos. The government of Lagos state, in its efforts to end rabies in the state, embarked on a free mass vaccination campaign for 1.5 million dogs against rabies in 2021. For the purpose of assessing the effort of the government and to study various factors that can inhibit or escalate rabies in Lagos to properly guide the government in its efforts to end the disease, we formulate a mathematical model as a system of ODEs. To investigate the dynamics of the disease in the state, the theory of reproductive ratio is applied. As this ratio increases beyond one, rabies invades the state and vice-versa. We show that if R-o <= 1, the disease-free equilibrium is globally asymptotically stable in the feasible region Omega. We also show that if R-o > 1, an endemic equilibrium exists and it is locally and globally stable in Omega. Further, we show that if R-o = 1, the model may exhibit backward bifurcation. We performed sensitivity analysis to determine the strength of the model parameters to rabies spread and eradication and also computed herd immunity to assess the strength of the vaccination program embarked upon by the government which targeted 60% dog population. To validate the analytical findings and gain more insight into the dynamics of rabies in Lagos state, simulations are run. The results indicate that vaccine efficacy and recruitment rate for dogs have serious effects on rabies transmission in Lagos state. It was also discovered that the detection of the exposed dogs through screening had to be integrated into the vaccination program of the government if the vaccination campaign of 1.5 million dogs by the government was to champion rabies transmission in Lagos state.

Automated summary

In order to control rabies transmission in Nigeria, the Lagos state government initiated a mass vaccination campaign for 1.5 million dogs in 2021. Through the development of a mathematical model and analysis, it was found that factors such as vaccine efficacy and dog recruitment rate greatly affect the success of the vaccination program. Simulations demonstrated that integrating screening measures and targeting 60% of the dog population in the vaccination campaign can effectively control rabies transmission in Lagos state.