☆ 4.2 Review

Broadly neutralizing antibodies for HIV treatment and cure approaches

CURRENT OPINION IN HIV AND AIDS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Multidisciplinary Sciences

Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

David A. Spencer et al.

Summary: Antibodies are increasingly used to treat and prevent viral infections. In this study, the researchers investigated the role of antibody-mediated effector and complement activity in protecting against SHIV in rhesus macaques. They found that enhancing complement function did not improve the protective efficacy of the antibody, suggesting that effector functions of the unmodified antibody contribute to its effectiveness.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Infectious Diseases

Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial

Henning Gruell et al.

Summary: This study investigated the effect of combining the broadly neutralising antibody 3BNC117 with the latency-reversing agent romidepsin in people with HIV-1 on suppressive antiretroviral therapy (ART). The results showed that this combination therapy was safe but did not delay viral rebound during treatment interruptions in individuals on long-term ART.

LANCET MICROBE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Combination anti-HIV antibodies provide sustained virological suppression

Michael C. Sneller et al.

Summary: The combination therapy with broadly neutralizing monoclonal antibodies can provide long-term virological suppression without antiretroviral therapy in individuals with HIV. This study offers guidance for future clinical trials involving next-generation antibodies with long half-lives.

NATURE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Prolonged viral suppression with anti-HIV-1 antibody therapy

Christian Gaebler et al.

Summary: Immunotherapy with anti-HIV-1 antibodies has the potential to suppress infection and increase the rate of clearance of infected cells. A clinical study showed that 76% of HIV-infected individuals who received a combination of antibodies maintained virologic suppression for at least 20 weeks without antiretroviral therapy. The administration of antibodies affected the HIV-1 reservoir, but further research is needed to define the precise effect of antibody immunotherapy.

NATURE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial

Boris Julg et al.

Summary: HIV-1 therapy with single or dual broadly neutralizing antibodies has shown viral escape, indicating the need for triple or more bNAb therapy. Results from human trials suggest that a combination of broad antiviral activity and high serum concentrations is necessary for viral control.

NATURE MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells

Jeremy Dufloo et al.

Summary: Researchers have found that broadly neutralizing antibodies (bNAbs) can not only neutralize HIV-1, but also block the release of viral particles by trapping them on the surface of infected cells. This study reveals an additional antiviral mechanism of bNAbs.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Immunology

HIV-gp140-Specific Antibodies Generated From Indian Long-Term Non-Progressors Mediate Potent ADCC Activity and Effectively Lyse Reactivated HIV Reservoir

Jayshree R. Dhande et al.

Summary: This study found that potent antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies can be generated from memory B cells of long-term non-progressors (LTNPs) with ADCC activity. These antibodies also have the ability to facilitate NK cell-mediated lysis of reactivated HIV reservoirs, highlighting their important role in reducing latent reservoirs.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Immunology

Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection

Seemal F. Awan et al.

Summary: This article reviews the use of anti-HIV-1 broadly neutralizing antibodies (bNAbs) for the prevention and treatment of HIV-1 infection. Multiple bNAbs have shown promising results in clinical trials. The article also discusses the current landscape of HIV-1 bNAbs in clinical development and the strategies employed to improve their breadth, potency, serum half-life, effector function, and administration.

CURRENT OPINION IN HIV AND AIDS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

Jesper D. Gunst et al.

Summary: This study found that early treatment with 3BNC117, with or without romidepsin, in newly diagnosed HIV-1 patients enhanced the decay rates of plasma HIV-1 RNA and accelerated clearance of infected cells. All groups showed significant reductions in the frequency of CD4(+) T cells containing intact HIV-1 provirus.

NATURE MEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition

Peter B. Gilbert et al.

Summary: By integrating serum concentration and in vitro inhibitory concentration, the PT80 biomarker can guide the effective prevention of HIV-1 acquisition. The PT80 biomarker can be used to predict HIV-1 prevention efficacy and is proposed as a tool for evaluating bNAb regimens and candidate vaccines.

NATURE MEDICINE (2022)

添加到收藏夹

Article Immunology

Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia

Yoshiaki Nishimura et al.

Summary: The study found that combination bNAb immunotherapy initiated on day 3 post-infection maintained durable CD8(+) T cell-mediated suppression of SHIVAD8 viremia and CD4(+) T cell levels in most of the treated monkeys during nearly 6 years of observation, with CD8(+) T cell immunity being the principal correlate of virus control. Treatment interventions beginning on week 2 post-infection also conferred controller status to some monkeys, but the time to suppression of plasma viremia was significantly delayed compared to early intervention on day 3.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Letter Virology

Relationships between Neutralization, Binding, and ADCC of Broadly Neutralizing Antibodies against Reservoir HIV

Yanqin Ren et al.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Article Immunology

Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins manufactured from Post-COVID-19 and COVID-19-Vaccinated Plasma Donations

Michael Karbiener et al.

Summary: Starting from September 2020, some immunoglobulin lots from US plasma contained neutralizing antibodies against the newly emerged SARS-CoV-2. The increasing numbers of post-COVID-19 donors led to a rise in antibody positivity to 93% by January 2021, with a predicted potency reaching 345 IU/mL by July 2021. The mean antibody titer in July 2021 immunoglobulin lots, contributed by plasma donors vaccinated against COVID-19, exceeded 600 IU/mL, surpassing even the levels found in earlier hyperimmune globulin products.

JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial

Kathryn E. Stephenson et al.

Summary: A study showed that a single dose of a broadly neutralizing, HIV-specific antibody PGT121 can transiently reduce viral load in some HIV-infected individuals and lead to durable virus suppression in certain cases. Further research is warranted to explore the potential of antibody-based therapeutic strategies for long-term HIV suppression.

NATURE MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anti-HIV-1 antibodies trigger non-lytic complement deposition on infected cells

Jeremy Dufloo et al.

EMBO REPORTS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity

Julia Niessl et al.

NATURE MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody

Mangaiarkarasi Asokan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study

Yehuda Z. Cohen et al.

PLOS ONE (2019)

添加到收藏夹

Article Biochemical Research Methods

Investigation of Sequence Clipping and Structural Heterogeneity of an HIV Broadly Neutralizing Antibody by a Comprehensive LC-MS Analysis

Vera B. Ivleva et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection

Rajeev Gautam et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Medicine, General & Internal

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults

Martin R. Gaudinski et al.

PLOS MEDICINE (2018)

添加到收藏夹

Article Immunology

Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117

Yehuda Z. Cohen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Pilar Mendoza et al.

NATURE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Yotam Bar-On et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Immunology

Randomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ART

Sharon A. Riddler et al.

OPEN FORUM INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Virology

Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys

Boris Julg et al.

JOURNAL OF VIROLOGY (2017)

添加到收藏夹

Article Virology

Comprehensive Cross-Clade Characterization of Antibody-Mediated Recognition, Complement-Mediated Lysis, and Cell-Mediated Cytotoxicity of HIV-1 Envelope-Specific Antibodies toward Eradication of the HIV-1 Reservoir

Shariq Mujib et al.

JOURNAL OF VIROLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Marina Caskey et al.

NATURE MEDICINE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization

Jad Maamary et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Ling Xu et al.

SCIENCE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity

Yaoxing Huang et al.

CELL (2016)

添加到收藏夹

Article Immunology

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

Jinghe Huang et al.

IMMUNITY (2016)

添加到收藏夹

Article Virology

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

Young D. Kwon et al.

JOURNAL OF VIROLOGY (2016)

添加到收藏夹

Article Medicine, General & Internal

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

K. J. Bar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

Timothee Bruel et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Infectious Diseases

Broadly Neutralizing Antibodies for HIV Eradication

Kathryn E. Stephenson et al.

CURRENT HIV/AIDS REPORTS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

David J. DiLillo et al.

CELL (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

Marina Caskey et al.

NATURE (2015)

添加到收藏夹

Article Cell Biology

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

Rebecca M. Lynch et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

添加到收藏夹

Article Virology

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo

Rebecca S. Rudicell et al.

JOURNAL OF VIROLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

Sung-Youl Ko et al.

NATURE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

Devin Sok et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Immunology

Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission

Marine Malbec et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Jinghe Huang et al.

NATURE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

Hugo Mouquet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Article Virology

Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop

Penny L. Moore et al.

JOURNAL OF VIROLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Broad neutralization coverage of HIV by multiple highly potent antibodies

Laura M. Walker et al.

NATURE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Johannes F. Scheid et al.

SCIENCE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Tongqing Zhou et al.

SCIENCE (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Xueling Wu et al.

SCIENCE (2010)

添加到收藏夹

Article Virology

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

Melissa D. Simek et al.

JOURNAL OF VIROLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

Johannes F. Scheid et al.

NATURE (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.