期刊
CANCER DISCOVERY
卷 13, 期 5, 页码 1043-1045出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-23-0229
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In this issue of Cancer Discovery, Adams and colleagues report the discovery of a powerful PROTAC, MDM2 degrader, which activates wild-type p53 and induces cancer cell death. They demonstrate through in vitro and in vivo experiments that the depletion of MDM2 by PROTAC effectively kills p53-mutant or p53-null cancer cells.
In this issue of Cancer Discovery , Adams and colleagues present the discovery of a potent PROTAC, MDM2 degrader, which activates wild-type p53 leading to cancer cell death. Importantly, in a number of in vitro and in vivo experiments, the authors show that the depletion of MDM2 by PROTAC kills p53-mutant or p53-null cancer cells.
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