Utilization of Silanols in Transition Metal-Catalyzed Organic Synthesis

The multifaceted implementation of silanols in organicsynthesisis reviewed from the standpoint of developments in transition metal-catalyzedreactions. The major properties of silanols are summarized accordingto the research fields that have utilized these intriguing species:silanols as nucleophiles to serve as bulky surrogates for water; silanolsas temporary ligands to control regioselectivity of metal-catalyzedreactions; silanols as coupling partners for transferring functionalgroups. These topics are summarized to provide opportunities for futuredevelopments in the chemistry of silanols.

Automated summary

The multifaceted implementation of silanols in organic synthesis is reviewed in terms of advances in transition metal-catalyzed reactions. The major properties of silanols are summarized, including their use as nucleophiles to serve as bulky surrogates for water, as temporary ligands to control the regioselectivity of metal-catalyzed reactions, and as coupling partners for transferring functional groups. These summaries provide opportunities for future developments in silanol chemistry.