Asymptomatic immunodeficiency-associated vaccine-derived poliovirus infections in two UK children

Article Public, Environmental & Occupational Health

Surveillance to Track Progress Toward Polio Eradication — Worldwide, 2020–2021

Amanda L. Wilkinson et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

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Article Surgery

Public health response to a case of paralytic poliomyelitis in an unvaccinated person and detection of poliovirus in wastewater-New York, June-August 2022

Ruth Link-Gelles et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Medicine, General & Internal

Sustained detection of type 2 poliovirus in London sewage between February and July, 2022, by enhanced environmental surveillance

Dimitra Klapsa et al.

Summary: Environmental surveillance in London identified genetically linked poliovirus isolates related to the Sabin vaccine strain, with an increasing proportion meeting the criteria for vaccine-derived poliovirus. Whole-genome sequencing confirmed transmission of a unique recombinant poliovirus lineage, now detected in Israel and the USA.

LANCET (2022)

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Article Public, Environmental & Occupational Health

Detection of a Highly Divergent Type 3 Vaccine-Derived Poliovirus in a Child with a Severe Primary Immunodeficiency Disorder — Chongqing, China, 2022

Ning Yao et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

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Article Medicine, General & Internal

Global epidemiology of vaccine-derived poliovirus 2016-2021: A descriptive analysis and retrospective case-control study

Yi An Lai et al.

Summary: This paper presents the global epidemiology of circulating vaccine-derived poliovirus (cVDPV) and finds that low vaccination coverage is associated with an increased risk of reporting cVDPV. This highlights the importance of maintaining high levels of vaccination for polio eradication efforts.

ECLINICALMEDICINE (2022)

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Article Microbiology

A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of V-7404 in Healthy Adult Volunteers

Martin K. Kankam et al.

Summary: The study showed that V-7404 was well absorbed after oral administration in healthy adult volunteers, with dose-proportional pharmacokinetic exposure and no significant accumulation. V-7404 demonstrated acceptable safety and pharmacokinetic profile, supporting further clinical investigation for the treatment of serious EV infections.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Article Medicine, General & Internal

Poliovirus excretion among children with primary immune deficiency in Pakistan: a pilot surveillance study protocol

Asma Sadruddin Pethani et al.

Summary: This study aims to establish a pilot surveillance system to identify and monitor VDPV excretion in children with PID and evaluate the use of Jeffrey Modell PID warning signs as a screening tool for PID in Pakistan.

BMJ OPEN (2021)

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Article Public, Environmental & Occupational Health