相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Insights into distinct signaling profiles of the μOR activated by diverse agonists
Qianhui Qu et al.
NATURE CHEMICAL BIOLOGY (2023)
Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling
Mohammad Seyedabad et al.
TRENDS IN BIOCHEMICAL SCIENCES (2022)
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD
Can Cao et al.
NEURON (2022)
Nalfurafine reduces neuroinflammation and drives remyelination in models of CNS demyelinating disease
Lisa Denny et al.
CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
Rajendra Uprety et al.
ELIFE (2021)
Structural Insights Accelerate the Discovery of Opioid Alternatives
Tao Che et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021 (2021)
Biased ligands at opioid receptors: Current status and future directions
Tao Che et al.
SCIENCE SIGNALING (2021)
Delineating the Ligand-Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor
Brendan Kelly et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)
Molecular insights into the biased signaling mechanism of the μ-opioid receptor
Xiaojing Cong et al.
MOLECULAR CELL (2021)
Structure of the neurotensin receptor 1 in complex with β-arrestin 1
Weijiao Huang et al.
NATURE (2020)
Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc
Dean P. Staus et al.
NATURE (2020)
The atomistic level structure for the activated human.-opioid receptor bound to the full Gi protein and the MP1104 agonist
Amirhossein Mafi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor
Carl-Mikael Suomivuori et al.
SCIENCE (2020)
Nanobody-enabled monitoring of kappa opioid receptor states
Tao Che et al.
NATURE COMMUNICATIONS (2020)
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
Alexander Gillis et al.
SCIENCE SIGNALING (2020)
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Reid H. J. Olsen et al.
NATURE CHEMICAL BIOLOGY (2020)
Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects
Danni Cao et al.
ACS CHEMICAL NEUROSCIENCE (2020)
Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion
Jeffrey J. Liu et al.
NEUROPSYCHOPHARMACOLOGY (2019)
Illuminating G-Protein-Coupling Selectivity of GPCRs
Asuka Inoue et al.
CELL (2019)
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists
Tobias Claff et al.
SCIENCE ADVANCES (2019)
Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations
Laura M. Wingler et al.
CELL (2019)
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Tao Che et al.
CELL (2018)
Catalytic activation of β-arrestin by GPCRs
Kelsie Eichel et al.
NATURE (2018)
Molecular mechanism of GPCR-mediated arrestin activation
Naomi R. Latorraca et al.
NATURE (2018)
Biased signalling: from simple switches to allosteric microprocessors
Jeffrey S. Smith et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Computational design of thermostabilizing point mutations for G protein-coupled receptors
Petr Popov et al.
ELIFE (2018)
GPU-Accelerated Molecular Dynamics and Free Energy Methods in Amber18: Performance Enhancements and New Features
Tai-Sung Lee et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2018)
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
Sheng Wang et al.
NATURE (2018)
Structure of the μ-opioid receptor-Gi protein complex
Antoine Koehl et al.
NATURE (2018)
Mechanisms of signalling and biased agonism in G protein-coupled receptors
Denise Wootten et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Structural determinants of 5-HT2B receptor activation and biased agonism
John D. McCorvy et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
G protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons
Jo-Hao Ho et al.
SCIENCE SIGNALING (2018)
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
Jing Huang et al.
NATURE METHODS (2017)
Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo
Michael Soeberdt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
The Role of Science in Addressing the Opioid Crisis
Nora D. Volkow et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor
Selena S. Schattauer et al.
CELLULAR SIGNALLING (2017)
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Daniel Wacker et al.
CELL (2017)
Nalfurafine hydrochloride, a selective κ opioid receptor agonist, has no reinforcing effect on intravenous self-administration in rhesus monkeys
Kaoru Nakao et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2016)
Structure-based discovery of opioid analgesics with reduced side effects
Aashish Manglik et al.
NATURE (2016)
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Tarsis F. Brust et al.
SCIENCE SIGNALING (2016)
Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts
Marco Schuetz et al.
SCIENTIFIC REPORTS (2016)
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Tarsis F. Brust et al.
SCIENCE SIGNALING (2016)
Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning
Chad W. Hopkins et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
Structural insights into μ-opioid receptor activation
Weijiao Huang et al.
NATURE (2015)
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
Wesley K. Kroeze et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
Wesley K. Kroeze et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Nalfurafine hydrochloride to treat pruritus: a review
Shigeki Inui
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2015)
The G Protein-Biased kappa-Opioid Receptor Agonist RB-64 Is Analgesic with a Unique Spectrum of Activities In Vivo
Kate L. White et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Functionally Selective Dopamine D2, D3 Receptor Partial Agonists
Dorothee Moeller et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion
Hugo A. Tejeda et al.
NEUROPSYCHOPHARMACOLOGY (2013)
A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphines
Scott M. DeWire et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
A Simple Method for Quantifying Functional Selectivity and Agonist Bias
Terry Kenakin et al.
ACS CHEMICAL NEUROSCIENCE (2012)
Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans
Mohini Ranganathan et al.
BIOLOGICAL PSYCHIATRY (2012)
6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment
Marie-Laure Rives et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges
K. Vanommeslaeghe et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing
K. Vanommeslaeghe et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Structure of the human κ-opioid receptor in complex with JDTic
Huixian Wu et al.
NATURE (2012)
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling
Andreas Bock et al.
NATURE COMMUNICATIONS (2012)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Delta and Kappa Opioid Receptors as Suitable Drug Targets for Pain
Todd W. Vanderah
CLINICAL JOURNAL OF PAIN (2010)
Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
Jeffery B. Klauda et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
Crystallizing membrane proteins using lipidic mesophases
Martin Caffrey et al.
NATURE PROTOCOLS (2009)
Additive Empirical Force Field for Hexopyranose Monosaccharides
Olgun Guvench et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
Two protonation switches control rhodopsin activation in membranes
Mohana Mahalingam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
HKL-3000:: the integration of data reduction and structure solution -: from diffraction images to an initial model in minutes
Wladek Minor et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
OPM: Orientations of proteins in membranes database
MA Lomize et al.
BIOINFORMATICS (2006)
On the role of the crystal environment in determining protein side-chain conformations
MP Jacobson et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Gz signaling:: emerging divergence from Gi signaling
MKC Ho et al.
ONCOGENE (2001)
TRK-820, a selective κ-opioid agonist, produces potent antinociception in cynomolgus monkeys
T Endoh et al.
JAPANESE JOURNAL OF PHARMACOLOGY (2001)
The effect of pH on β2 adrenoceptor function -: Evidence for protonation-dependent activation
P Ghanouni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)