期刊
KIDNEY & BLOOD PRESSURE RESEARCH
卷 41, 期 6, 页码 997-1007出版社
KARGER
DOI: 10.1159/000452595
关键词
Biomarker; Chronic kidney disease; EGF; Epidermal Growth Factor; Fibrosis; Glomerulonephritis; Kidney; NGAL; Neutrophil gelatinase-associated lipocalin; MCP-1; Monocyte chemoattractant protein-1; Tubulointerstitial
资金
- Faculty of Medicine, Ramathibodi Hospital
- National Science and Technology Development Agency (NSTDA). Thailand
Background/Aims:The degree of tubular atrophy and interstitial fibrosis (IFTA) is an important prognostic factor in glomerulonephritis. Imbalance between pro -inflammatory cytokines such as monocyte chemoattractant protein-1 (MCP-1) and protective cytokines such as epidermal growth factor (EGF) likely determine IFTA severity. In separate studies, elevated MCP-1 and decreased EGF have been shown to be associated with IFTA severity. In this study, we aim to evaluate the predictive value of urinary EGF/MCP-1 ratio compared to each biomarker individually for moderate to severe IFTA in primary glomerulonephritis (GN). Methods: Urine samples were collected at biopsy from primary GN (IgA nephropathy, focal and segmental glomerulosclerosis, minimal change disease, membranous nephropathy). MCP-1 and EGF were analyzed by enzyme-linked immunosorbent assay. Results: EGF, MCP-1 and EGF/MCP-1 ratio from primary GN, all correlated with IFTA (n=58). By univariate analysis, glomerular filtration rate. EGF, and EGF/MCP-1 ratio were associated with IFTA. By multivariate analysis, only EGF/MCP-1 ratio was independently associated with IFTA. EGF/MCP-1 ratio had a sensitivity of 88% and specificity of 74 % for IFTA. FGF/MCP-1 had good discrimination for IFTA (AUC=0.85), but the improvement over EGF alone was not significant. Conclusion: EGF/MCP-1 ratio is independently associated IFTA severity in primary glomerulonephritis, but the ability of EGF/MCP-1 ratio to discriminate moderate to severe IFTA may not be much better than EGF alone. (C) 2016 The Author(s) Published by S. Karger AG, Basel
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