期刊
EPIGENOMICS
卷 15, 期 5, 页码 271-281出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2022-0277
关键词
intervertebral disc; intervertebral disc degeneration; low back pain; miRNA; miRNA-based therapy; regenerative therapy
Intervertebral disc degeneration (IDD) is a major cause of low back pain and has significant social and economic impact. Current medical and surgical therapies are ineffective, but miRNA-based therapies show promise in regulating the pathogenesis of IDD. Overcoming obstacles associated with these therapies will allow for their translation from bench to bedside in the near future.
Intervertebral disc degeneration (IDD) is the main cause of low back pain, which is a healthcare concern associated with high social and economic burden. The current medical and surgical therapies are inadequate and ineffective. Several miRNAs have been identified that modulate (via up- or down-regulation) the pathogenesis of IDD through various signaling pathways. Understanding the nature of this regulation and their signaling pathways will enable researchers to manipulate miRNA regulation to develop miRNA-based therapies. The development of miRNA-based therapies opens a future window through which to decrease the IDD process or regenerate the intervertebral disc. In the near future, the obstacles associated with miRNA-based therapies will be overcome and these therapies will move from the bench to the bedside.
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