4.4 Article

Combination of hsa_circ_0004674 and lncRNA OIP5-AS1 as a novel clinical biomarker used to predict prognosis in patients with osteosarcoma

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Article Cell Biology

Doxorubicin-induced novel circRNA_0004674 facilitates osteosarcoma progression and chemoresistance by upregulating MCL1 through miR-142-5p

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Summary: This study identified a novel doxorubicin-induced circular RNA, hsa_circ_0004674, which was upregulated in osteosarcoma chemoresistant cell lines and tissues and correlated with poor prognosis in patients. Knockdown of circ_0004674 inhibited chemoresistance, proliferation, migration, invasion, tumor growth, and induced cell cycle arrest and apoptosis by regulating the expression of the antiapoptotic protein MCL1. Moreover, circ_0004674 could compete with MCL1 for binding to miR-142-5p, suggesting a potential therapeutic target for osteosarcoma.

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