4.7 Article

Genome-Wide Mapping of the Escherichia coli PhoB Regulon Reveals Many Transcriptionally Inert, Intragenic Binding Sites

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The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization

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Summary: Escherichia coli strains including enterohemorrhagic E. coli (EHEC) and enteropathogenic E. coli (EPEC) can cause severe gastroenteritis. An RNA called EsrL promotes the pathogenicity, adhesion, and biofilm formation of these strains. The expression of EsrL is repressed by PhoB under low-phosphate conditions, but relieved in a phosphate-rich environment. EsrL interacts with and stabilizes important transcripts, leading to increased adhesion and colonization in the host intestine.

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