Potential protective function of green tea polyphenol EGCG against high glucose-induced cardiac injury and aging

Green tea and its active extracts have been widely used in a variety of dietary supplements. However, to date, the interaction of these bioactive compounds in green tea and their protein targets are not well studied. We first used the bioinformatics analysis of the relevant diabetes-related targets with the green tea bioactive compounds target proteins to construct a protein interaction (PPI) network to screen the core targets. The results of in vitro experiments showed that EGCG, a major polyphenolic component of green tea, inhibited HG-induced cardiomyocyte hypertrophy, inflammation, oxidative stress response, and cellular senescence. It was found that the PPARG-dependent pathways were involved in the protective effects of EGCG against HG-induced myocardial injury and senescence. This study comprehensively explored the role of EGCG in high glucose-induced myocardial cell injury and aging.

Automated summary

Green tea and its active extracts are commonly used in dietary supplements, but little is known about their interactions with protein targets. In this study, the researchers used bioinformatics to analyze the interactions between diabetes-related targets and green tea bioactive compounds, leading to the identification of core targets. In vitro experiments demonstrated that the major polyphenolic component of green tea, EGCG, inhibited high glucose-induced cardiomyocyte hypertrophy, inflammation, oxidative stress response, and cellular senescence. The protective effects of EGCG were found to be mediated through PPARG-dependent pathways. This study provides comprehensive insights into the role of EGCG in high glucose-induced myocardial cell injury and aging.