期刊
ONCOTARGETS AND THERAPY
卷 16, 期 -, 页码 115-132出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S335934
关键词
breast cancer; HER2; monoclonal antibodies; tyrosine kinase inhibitors; antibody-drug conjugates
Around 20% of breast cancers are associated with amplification or overexpression of human epidermal growth factor receptor 2 (HER2). Anti-HER2-targeted agents, including monoclonal antibodies, tyrosine kinase inhibitors (TKIs), and antibody-drug conjugates (ADCs) are the cornerstone of cancer therapeutic strategies. However, resistance to treatment remains a challenge in HER2-positive breast cancer, and the introduction of new agents has created awareness of potential adverse events, posing challenges in daily patient care.
Around 20% of breast cancers are associated with amplification or overexpression of human epidermal growth factor receptor 2 (HER2). In this setting, anti-HER2-targeted agents are the cornerstone of cancer therapeutic strategies. This includes monoclonal antibodies, tyrosine kinase inhibitors (TKIs) and, recently, antibody-drug conjugates (ADCs). With the advent of these new alternatives, the decision-making process has become more complex, especially with regard to the treatment sequence possibilities. In spite of the fact that overall survival has significantly improved accordingly, resistance to treatment remains a challenge in HER2-positive breast cancer. The introduction of new agents has created awareness regarding new potential specific adverse events, and consequently, their increasing application pose major challenges in daily patient care. This review describes the therapeutic landscape for HER2-positive advanced breast cancer (ABC) and evaluates its benefits and risks in the clinical setting.
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