期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 17, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2023.1124333
关键词
muscarinic M1 receptor; muscarinic M4 receptor; schizophrenia; sub-group; neuroimaging; postmortem CNS; xanomeline; KarXT
Pre-clinical models, postmortem and neuroimaging studies all suggest that muscarinic receptors are involved in the molecular pathology of schizophrenia. Clinical trials have shown that activating central muscarinic M1 and M4 receptors can reduce the severity of symptoms. This review discusses the growing evidence for the critical roles of muscarinic M1 and M4 receptors in CNS functions and their implication in schizophrenia.
Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic receptors in the molecular pathology of schizophrenia. From these data it was proposed that activation of the muscarinic M1 and/or M4 receptor would reduce the severity of the symptoms of schizophrenia. This hypothesis is now supported by results from two clinical trials which indicate that activating central muscarinic M1 and M4 receptors can reduce the severity of positive, negative and cognitive symptoms of the disorder. This review will provide an update on a growing body of evidence that argues the muscarinic M1 and M4 receptors have critical roles in CNS functions that are dysregulated by the pathophysiology of schizophrenia. This realization has been made possible, in part, by the growing ability to visualize and quantify muscarinic M1 and M4 receptors in the human CNS using molecular neuroimaging. We will discuss how these advances have provided evidence to support the notion that there is a sub-group of patients within the syndrome of schizophrenia that have a unique molecular pathology driven by a marked loss of muscarinic M1 receptors. This review is timely, as drugs targeting muscarinic receptors approach clinical use for the treatment of schizophrenia and here we outline the background biology that supported development of such drugs to treat the disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据