4.6 Review

Exosome derived from human adipose-derived stem cell improve wound healing quality: A systematic review and meta-analysis of preclinical animal studies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Exosomal microRNA-125a-3p from human adipose-derived mesenchymal stem cells promotes angiogenesis of wound healing through inhibiting PTEN

Li Pi et al.

Summary: The study reveals that miR-125a-3p from HADSCs promotes angiogenesis and wound healing by inhibiting PTEN in HUVECs. Additionally, miR-125a-3p in HADSCs exosomes enhances the viability and migration of HUVECs, contributing to angiogenesis.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

Review Instruments & Instrumentation

Mesenchymal stem cells are prospective novel off-the-shelf wound management tools

Poonam Malhotra et al.

Summary: This article outlines the role of MSCs and their secretome in treating and promoting wound healing, as well as their effects on tissue inflammation, immunomodulation, angiogenesis, and scar-free healing. The mechanisms by which MSCs contribute to tissue repair and factors influencing healing behavior are further evaluated. The advancements in extending cell lifespan, genetic modifications, and bioengineered delivery methods for faster healing are also discussed, along with the challenges in commercializing cell-based therapies and advocating for their application in tissue regeneration.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Article Cell Biology

Minimum criteria for defining induced mesenchymal stem cells

Mahmood S. Choudhery et al.

Summary: Mesenchymal stem cells (MSCs) have potential for cell-based therapies, but limitations such as low cell number, restricted expansion and differentiation capacity, and donor-related heterogeneity have led to interest in induced mesenchymal stem cells (iMSCs). It is important to define iMSCs separately from primary MSCs and propose additional characterization criteria to ensure their safe and effective use in clinical applications.

CELL BIOLOGY INTERNATIONAL (2022)

Review Cell & Tissue Engineering

Application of ADSCs and their Exosomes in Scar Prevention

Cong Li et al.

Summary: Scar is a common way of healing after tissue injury, but the process of scar formation is complex and not fully understood. Fibroblasts and myofibroblasts play important roles in wound healing and scar formation, while adipose tissue-derived stem cells and their exosomes also have an impact on it.

STEM CELL REVIEWS AND REPORTS (2022)

Article Cell & Tissue Engineering

Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing

June Seok Heo et al.

Summary: The study demonstrated that AEXOs not only alleviate inflammation response but also promote wound healing. Therefore, AEXOs represent a novel stem cell-based therapeutic strategy for wound healing.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

Review Biochemistry & Molecular Biology

Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases

Enzo Manchon et al.

Summary: Endosome-derived small extracellular vesicles (EVs), also known as exosomes, play a critical role in intercellular communication and have therapeutic potential in regenerative medicine. Stem cell-derived EVs are effective in repair and regeneration, with the human placenta offering a promising allogeneic stem cell source. Advancements in cell-free therapeutics provide new hope and perspectives for safe and effective treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, Research & Experimental

LncRNA NORAD regulates scar hypertrophy via miRNA-26a mediating the regulation of TGFβR1/2

Jun Qi et al.

Summary: This study identified abnormal expression of LncRNA NORAD, miR-26a, and TGF-beta receptors in hypertrophic scar tissue. LncRNA NORAD regulates HSF proliferation via miR-26a mediating the regulation of TGF-beta R2/R1. Cell cycle and apoptosis are also affected by this regulatory mechanism.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2021)

Article Cell & Tissue Engineering

Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis

Yan Li et al.

Summary: ADSC-Exo has shown to effectively inhibit the proliferation and migration of HSFs, decrease the expression of related proteins, promote wound healing in mice, and reduce collagen deposition. miR-192-5p plays a positive role in fibrosis by targeting IL-17RA and regulating the Smad pathway.

STEM CELL RESEARCH & THERAPY (2021)

Article Cell & Tissue Engineering

Combined topical and systemic administration with human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration

Yang Zhou et al.

Summary: This study investigated the potential clinical application roles of human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes (hADSC-Exo) in cutaneous wound healing. The combined administration of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration showed additional benefits in promoting wound healing, accelerating re-epithelialization, reducing scar widths, and enhancing angiogenesis and collagen synthesis.

STEM CELL RESEARCH & THERAPY (2021)

Article Medicine, Research & Experimental

Adipose mesenchymal stem cell-derived exosomes accelerate skin wound healing via the lncRNA H19/miR-19b/SOX9 axis

Li Qian et al.

Summary: This study demonstrates that the high expression of H19 in exosomes derived from adipose mesenchymal stem cells accelerates skin tissue wound healing by upregulating SOX9 via miR-19b.

LABORATORY INVESTIGATION (2021)

Article Medicine, Research & Experimental

LncRNA XIST shuttled by adipose tissue-derived mesenchymal stem cell-derived extracellular vesicles suppresses myocardial pyroptosis in atrial fibrillation by disrupting miR-214-3p-mediated Arl2 inhibition

Boyu Yan et al.

Summary: This study demonstrates that extracellular vesicles from mouse adipose tissue-derived mesenchymal stem cells deliver the long non-coding RNA XIST into cardiomyocytes, which then inhibits NLRP3 inflammasome activation and myocardial pyroptosis by reducing the miR-214-3p-mediated inhibition of the GTP-binding protein Arl2.

LABORATORY INVESTIGATION (2021)

Article Oncology

Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling

Ruihong Yuan et al.

Summary: The study showed that miR-29a-modified hADSC exosomes can decrease scar formation by inhibiting the TGF-beta 2/Smad3 signaling pathway, as well as inhibiting the proliferation and migration of HSFBs.

MOLECULAR MEDICINE REPORTS (2021)

Article Dermatology

Effect of MicroRNA-146a Modified Adipose-Derived Stem Cell Exosomes on Rat Back Wound Healing

Gangquan Chen et al.

Summary: The study showed that MicroRNA-146a modified adipose-derived stem cell exosomes could promote the proliferation and migration of fibroblasts, enhance neovascularization, and contribute to faster wound healing.

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS (2021)

Article Oncology

miR-211-5p inhibits the proliferation, migration, invasion, and induces apoptosis of human hypertrophic scar fibroblasts by regulating TGF beta R2 expression

Jun Tang et al.

Summary: miR-211-5p inhibits activation of the TGF-beta R2/Smad3 signaling pathway by targeting TGF beta R2, suppressing proliferation, migration, invasion, and ECM production of hHSFs, inducing their apoptosis.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Chemistry, Multidisciplinary

Adipose-Derived Biogenic Nanoparticles for Suppression of Inflammation

Ming Tian et al.

Review Cell Biology

Adipose-derived mesenchymal stem cell exosomes: a novel pathway for tissues repair

Yuan Fang et al.

CELL AND TISSUE BANKING (2019)

Article Biochemistry & Molecular Biology

Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells enhance angiogenesis through VEGF/VEGF-R

Yudi Han et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial-Mesenchymal Transition

Sevindzh Kletukhina et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biotechnology & Applied Microbiology

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

Maria Yu. Konoshenko et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Article Cell & Tissue Engineering

Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer

Rosanna C. Ching et al.

STEM CELL RESEARCH & THERAPY (2018)

Review Cell Biology

Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy

Jennifer Phan et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

Article Medicine, Research & Experimental

Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum

Yue-Ting Tang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

Impact of Antibiotics on the Proliferation and Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

Aleksandra Skubis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Dermatology

Non-Coding RNAs: New Players in Skin Wound Healing

Eva K. Herter et al.

ADVANCES IN WOUND CARE (2017)

Article Health Care Sciences & Services

SYRCLE's risk of bias tool for animal studies

Carlijn R. Hooijmans et al.

BMC MEDICAL RESEARCH METHODOLOGY (2014)

Article Cell & Tissue Engineering

Stimulation of Skin and Wound Fibroblast Migration by Mesenchymal Stem Cells Derived from Normal Donors and Chronic Wound Patients

Luis Rodriguez-Menocal et al.

STEM CELLS TRANSLATIONAL MEDICINE (2012)