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Review
Virology
Marcos Jesse Abrahao Silva et al.
Summary: This research aimed to review the immunopathological elements that contribute to the progression of COVID-19. A systematic review was conducted using various databases and search terms. The study identified several key factors, such as SARS-CoV-2 spike proteins, cellular proteases, leukocytes, cytokines, and proteolytic cascades, that play a role in the hyperinflammatory response and subsequent complications. It is important to control the dysregulation of the immune response and systemic inflammation for patients' recovery.
Article
Medicine, General & Internal
Ruediger Gross et al.
Summary: According to a study on a cohort of individuals who received heterologous ChAdOx1 nCoV-19 BNT162b2 vaccination, the regimen induced potent humoral and cellular immune responses, with strong neutralization of the most prevalent SARS-CoV-2 variants. The results suggest that this heterologous vaccination regimen is at least as immunogenic and protective as homologous vaccinations and also offers protection against current variants of concern.
Article
Public, Environmental & Occupational Health
Linh Luong et al.
Summary: During the first wave of the pandemic, the prevalence of SARS-CoV-2 infection at sites serving people experiencing homelessness in Toronto varied significantly over time, with some sites showing lower infection rates possibly due to overall time trends, expansion of outreach-based testing to include sites without known outbreaks, and/or individual site characteristics.
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2022)
Article
Medicine, General & Internal
The Lancet
News Item
Multidisciplinary Sciences
Leslie Roberts
Article
Medicine, General & Internal
Paolo Pelosi et al.
Summary: The latest guidelines for the hospital care of patients with COVID-19-related acute respiratory failure recommend the use of noninvasive respiratory support (NIRS) instead of early intubation. Different clinical-radiological phenotypes of severe COVID-19 pneumonia have been categorized, which can benefit from the application of external positive end-expiratory pressure (PEEP) during noninvasive mechanical ventilation. Excessive negative pleural pressure swings (P-pl) can play a critical role in lung and diaphragm damage in patients treated with noninvasive respiratory support. Routine respiratory monitoring is necessary to prevent the worsening of respiratory condition and consider early initiation of invasive mechanical ventilation. Further research is needed to apply different monitoring methods in clinical practice and optimize ventilatory management for patients with acute respiratory distress syndrome due to SARS-CoV-2 infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Francesco Salton et al.
Summary: This study investigated the cytokine profiles in patients with SARS-CoV-2-induced ARDS who were treated with glucocorticoids (GCs). The study found that patients in the invasive mechanical ventilation (IMV) group had higher inflammation levels at intubation compared to the non-invasive ventilation (NIV) group, suggesting a higher resistance to GCs. Further studies are needed to determine the prognostic value of cytokine patterns and the optimal treatment for these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Virology
Jinsoo Kim et al.
Summary: This study found that individuals aged >= 60 years who were not fully vaccinated against COVID-19 had limited protection against the Omicron variant, while receiving two to three doses of the vaccine provided cross-variant humoral immunity against Omicron for at least 3 months.
Article
Medicine, General & Internal
Nidia Celeste Horie et al.
Summary: This study describes the profile of professionals assisting homeless and socially vulnerable populations tested for COVID-19 and investigates potential associations between exposure at different locations and infection. The study also examines disease symptoms and progression and explores potential associations with age, sex, and exposure at various locations. The results suggest that a history of symptoms is associated with positive serology for COVID-19, and shared housing conditions tend to be associated with a higher risk of infection. Onset of symptoms is also associated with workplace exposure and shared housing conditions in seropositive participants.
EINSTEIN-SAO PAULO
(2022)
Article
Infectious Diseases
Theodore W. Heyming et al.
Summary: The majority of pediatric healthcare workers who received two doses of the vaccine tested positive for SARS-CoV-2 antibodies using a rapid test, with further confirmation from CI-ELISA testing. This suggests that the rapid test may be a reliable method for assessing antibody responses to SARS-CoV-2 vaccination.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Minjeong Nam et al.
Summary: Both BNT162b2 and ChAdOx1 nCoV-19 vaccines elicited robust humoral responses, with strong correlations observed between sCOVG, CoV-2 IgG II, and cPASS. sCOVG and CoV-2 IgG II could potentially predict the presence of neutralizing antibodies against SARS-CoV-2.
MICROBIOLOGY SPECTRUM
(2021)
Article
Gastroenterology & Hepatology
Paul J. Thuluvath et al.
Summary: The study found that 61% of liver transplant recipients and 24% of patients with liver disease had poor antibody responses after receiving the SARS-CoV-2 vaccine. Immunocompromised status, vaccination with a single dose of Johnson & Johnson vaccine, and use of 2 or more immunosuppressive medications were associated with poor immune responses.
JOURNAL OF HEPATOLOGY
(2021)
Letter
Infectious Diseases
Matthias Tenbusch et al.
LANCET INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Tina Schmidt et al.
Summary: In healthy adults, vaccination with an mRNA vaccine as a booster, regardless of the initial vaccine, resulted in higher levels of spike-specific antibodies and T cells compared to booster vaccination with ChAdOx1 nCov-19. Heterologous vaccination with ChAdOx1 nCoV-19 followed by an mRNA vaccine induced strong immune responses with acceptable reactogenicity, showing similar or better effects than homologous mRNA vaccine regimens.
Article
Biochemistry & Molecular Biology
Joana Barros-Martins et al.
Summary: A study found that booster vaccination with BNT162b2 in healthcare professionals previously vaccinated with ChAdOx-1 nCoV-19 elicited more neutralizing antibodies and higher frequencies of virus-specific T cells. Additionally, BNT162b2 induced high titers of neutralizing antibodies against variants of concern, such as B.1.1.7, B.1.351, and P.1.
Article
Medicine, General & Internal
Qun Li et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Massimo Ralli et al.
JOURNAL OF PUBLIC HEALTH RESEARCH
(2020)
