4.6 Article

ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Virology

ERVWE1 Reduces Hippocampal Neuron Density and Impairs Dendritic Spine Morphology through Inhibiting Wnt/JNK Non-Canonical Pathway via miR-141-3p in Schizophrenia

Wei Yao et al.

Summary: Human endogenous retroviruses (HERVs) are remnants of ancestral germline infections by exogenous retroviruses. In this study, ERVWE1 was found to change the density and morphology of dendritic spines in schizophrenia through inhibiting the Wnt/c-Jun N-terminal kinases non-canonical pathway via miR-141-3p. miR-141-3p, Wnt5a, and Arp2 may serve as potential clinical blood-based biomarkers or therapeutic targets for schizophrenia.

VIRUSES-BASEL (2023)

Article Biochemistry & Molecular Biology

HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia

Xuhang Li et al.

Summary: Schizophrenia is a severe neuropsychiatric disorder with unknown precise pathogenesis. This study shows that there is an increased level of Interferon beta (IFN-beta) in the serum of schizophrenia patients, which is positively correlated with HERV-W ENV. In addition, a decrease in serum long intergenic non-protein coding RNA 1930 (linc01930) is negatively correlated with HERV-W ENV and IFN-beta. HERV-W ENV promotes IFN-beta expression and neuronal apoptosis by suppressing linc01930, and the cGAS/STING pathway is involved. The monoclonal antibody GNbAC1 targeting HERV-W ENV may be a potential therapeutic choice for schizophrenia.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Immunology

TRPV4 contributes to ER stress and inflammation: implications for Parkinson's disease

Na Liu et al.

Summary: TRPV4 is involved in the loss of DA neurons and movement deficits in the substantia nigra of PD mice. This study provides new molecular targets and gene therapy approaches for the treatment of PD in the future.

JOURNAL OF NEUROINFLAMMATION (2022)

Article Medicine, General & Internal

Schizophrenia

Sameer Jauhar et al.

LANCET (2022)

Review Physiology

ER-PHAGY: MECHANISMS, REGULATION, AND DISEASES CONNECTED TO THE LYSOSOMAL CLEARANCE OF THE ENDOPLASMIC RETICULUM

Fulvio Reggiori et al.

Summary: ER-phagy is the process of degrading portions of the endoplasmic reticulum (ER) within lysosomes or vacuoles. It plays a role in recycling cytoplasmic material and organelles, regulating ER size and activity, and removing potentially cytotoxic material. Dysfunctional ER-phagy is associated with specific human diseases and can be targeted by pathogens.

PHYSIOLOGICAL REVIEWS (2022)

Article Virology

HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk

Qiujin Yan et al.

Summary: The study reveals a relationship between HERV-W ENV and the dopaminergic system in schizophrenia, showing that HERV-W ENV can increase dopamine concentration by regulating dopamine metabolism and induce the expression of dopamine receptor D2. Additionally, HERV-W ENV causes structural and functional abnormalities in dopamine neurons.

VIRUSES-BASEL (2022)

Article Plant Sciences

Subcellular dynamics and protein-protein interactions of plant sucrose transporters

Varsha Garg et al.

Summary: This article summarizes the research progress on interacting proteins, oligomeric complex formation, post-translational modification, and stress responses in SUTs of higher plants.

JOURNAL OF PLANT PHYSIOLOGY (2022)

Article Immunology

Temporal proteomics of human cerebrospinal fluid after severe traumatic brain injury

Sandy R. Shultz et al.

Summary: In this study, the changes in the cerebrospinal fluid (CSF) proteome after severe traumatic brain injury (TBI) were evaluated using high-resolution mass spectrometry. The results showed a robust innate immune response and downregulated pathways involved in nervous system development after TBI. Additionally, several proteins were identified as potential biomarkers or therapeutic targets for brain damage based on their differential regulation after severe TBI.

JOURNAL OF NEUROINFLAMMATION (2022)

Article Oncology

Glycoprotein α-Subunit of Glucosidase II (GIIα) is a novel prognostic biomarker correlated with unfavorable outcome of urothelial carcinoma

Qiongqiong Lin et al.

Summary: Through the study, it was found that glycosylation modification plays an important role in tumor angiogenesis, invasion, and metastasis. The elevated expression of GANAB was found to be correlated with poor prognosis of UC, as well as tumor grade, stage, and molecular subtype.

BMC CANCER (2022)

Review Biochemistry & Molecular Biology

Relationship between Brain Metabolic Disorders and Cognitive Impairment: LDL Receptor Defect

Dong-Yong Hong et al.

Summary: This review summarizes the important role of low-density lipoprotein receptor in brain cholesterol metabolism and its association with cognitive deficits and neurodegenerative brain diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

Roberto De Masi et al.

Summary: Glycans are an important component of living matter with metabolic, structural, and modulatory functions. Abnormal glycans can lead to protein misfolding and cyst formation in certain diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Medicine, Research & Experimental

CREB-associated glycosylation and function in human disease

Ning Zhang et al.

Summary: The shortcomings of mRNA sequencing have led to a shift towards proteomics as a hotspot for research. Post-translational modifications, such as phosphorylation and glycosylation, have significant consequences on disease initiation. This review comprehensively discusses how the glycosylation modification of CREB affects targeted gene expression and disease development.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2022)

Review Neurosciences

The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review

Ruqin Zhou et al.

Summary: Schizophrenia and antipsychotic-induced weight gain/obesity may be associated with hypothalamic endoplasmic reticulum stress pathway, which could lead to multiple changes in the body including hyperphagia, decreased energy expenditure, and central inflammation.

FRONTIERS IN NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

Dysregulation of the unfolded protein response (UPR) in the dorsolateral prefrontal cortex in elderly patients with schizophrenia

Pitna Kim et al.

Summary: Research has identified abnormalities in protein processing in schizophrenia patients, particularly dysregulation in the IRE1α pathway. This dysfunction may lead to abnormal responses to cellular stress and contribute to the protein processing abnormalities previously observed in schizophrenia.

MOLECULAR PSYCHIATRY (2021)

Article Cell Biology

Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance

Yan Zhou et al.

Summary: Our study revealed that Syncytin-1 expression is up-regulated in HCC, particularly in advanced stages, and can serve as a predictor of patient prognosis. Furthermore, detailed analysis showed a significant association between Syncytin-1 and HBsAg positivity in HCC patients, suggesting a key role in the development and treatment of HCC.

CELL DEATH DISCOVERY (2021)

Review Psychiatry

Neuroimaging Biomarkers in Schizophrenia

Nina Kraguljac et al.

Summary: Schizophrenia is a complex neuropsychiatric syndrome with no objective biological markers available for diagnostic or treatment decisions. Neuroimaging is considered a promising tool for biomarker development in schizophrenia, as it can capture phenotypic variations in disease targets, validate new treatment targets, predict response, aid in therapy selection, and provide rationale for personalized treatments.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

Article Virology

Human endogenous retrovirus W family envelope protein (HERV-W env) facilitates the production of TNF-α and IL-10 by inhibiting MyD88s in glial cells

Xiuling Wang et al.

Summary: The study revealed that HERV-W env upregulates the expressions of TNF-alpha and IL-10 by inhibiting the production of MyD88s in glial cells. This immune pathogenesis mechanism involving TLR4 and MyD88 sheds light on the role of HERV-W env in neuropsychiatric disorders.

ARCHIVES OF VIROLOGY (2021)

Review Neurosciences

Phosphorylation and Glycosylation of Amyloid-β Protein Precursor: The Relationship to Trafficking and Cleavage in Alzheimer's Disease

Xi-Jun Song et al.

Summary: Alzheimer's disease is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles. The main constituent of senile plaques, Aβ peptide, is derived from AβPP through cleaving by enzymes. Post-translational modifications like phosphorylation and glycosylation of AβPP may affect its trafficking and cleavage.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Chemistry, Medicinal

GANAB as a Novel Biomarker in Multiple Sclerosis: Correlation with Neuroinflammation and IFI35

Roberto De Masi et al.

Summary: The study found that GANAB expression levels were associated with disease activity and treatment response in multiple sclerosis patients, showing potential as a predictive biomarker of neuroinflammation.

PHARMACEUTICALS (2021)

Article Psychiatry

CPEB1, a novel risk gene in recent-onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1

Ya-Ru Xia et al.

Summary: CPEB1 and NDUFV2 are potential blood-based biomarkers and pathogenic factors in schizophrenia. The study reveals a novel mechanism of ERVWE1 in the etiology of schizophrenia, showing its role in inhibiting complex I activity in SH-SY5Y cells through the CPEB1/NDUFV2P1/NDUFV2 signaling pathway.

WORLD JOURNAL OF PSYCHIATRY (2021)

Review Biology

The Unfolded Protein Response: An Overview

Adam Read et al.

Summary: The unfolded protein response (UPR) is a cellular mechanism for maintaining protein folding balance in the endoplasmic reticulum. It is activated when unfolded proteins accumulate, leading to an increased load on folding molecules. The UPR works to reduce the number of unfolded proteins through various pathways, and if successful, restores protein folding balance; however, failure can potentially result in cell death.

BIOLOGY-BASEL (2021)

Article Psychiatry

Genome wide study of tardive dyskinesia in schizophrenia

Keane Lim et al.

Summary: TD is a severe condition characterized by repetitive involuntary movement, often seen in patients treated with antipsychotics. A recent study identified a novel locus and three suggestive loci related to immune pathways. Further research is needed to replicate the findings and evaluate the polygenic architecture underlying TD.

TRANSLATIONAL PSYCHIATRY (2021)

Review Biochemistry & Molecular Biology

Roles of XBP1s in Transcriptional Regulation of Target Genes

Sung-Min Park et al.

Summary: XBP1s is an active transcription factor that plays a critical role in regulating UPR target genes to reduce ER stress. It also controls the transcription of genes involved in lipid and glucose metabolism, as well as immune responses. Understanding the target genes and transcriptional regulatory mechanisms of XBP1s will aid in developing new therapeutic targets for various diseases.

BIOMEDICINES (2021)

Article Psychiatry

Dystrophy of Oligodendrocytes and Adjacent Microglia in Prefrontal Gray Matter in Schizophrenia

Natalya A. Uranova et al.

FRONTIERS IN PSYCHIATRY (2020)

Review Neurosciences

Cellular Proteostasis in Neurodegeneration

Alberim Kurtishi et al.

MOLECULAR NEUROBIOLOGY (2019)

Review Microbiology

Origins and evolutionary consequences of ancient endogenous retroviruses

Welkin E. Johnson

NATURE REVIEWS MICROBIOLOGY (2019)

Review Psychiatry

Neuroinflammation and Schizophrenia

Peter F. Buckley

CURRENT PSYCHIATRY REPORTS (2019)

Article Biochemistry & Molecular Biology

Rab7a modulates ER stress and ER morphology

Duarte Mateus et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

Article Clinical Neurology

The aliens inside us: HERV-W endogenous retroviruses and multiple sclerosis

Antonina Dolei

MULTIPLE SCLEROSIS JOURNAL (2018)

Review Psychiatry

Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia

Alireza Mohammadi et al.

PSYCHIATRY RESEARCH (2018)

Article Clinical Neurology

The aliens inside us: HERV-W endogenous retroviruses and multiple sclerosis

Antonina Dolei

MULTIPLE SCLEROSIS JOURNAL (2018)

Article Medicine, Research & Experimental

Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia

Lei Cai et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Review Biochemistry & Molecular Biology

The role of endoplasmic reticulum stress in neurodegenerative disease

Chunchen Xiang et al.

APOPTOSIS (2017)

Review Behavioral Sciences

Crosstalk between endoplasmic reticulum stress and oxidative stress in schizophrenia: The dawn of new therapeutic approaches

Shivangi Patel et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Article Clinical Neurology

IRE1 signaling exacerbates Alzheimer's disease pathogenesis

Claudia Duran-Aniotz et al.

ACTA NEUROPATHOLOGICA (2017)

Review Biochemistry & Molecular Biology

Cell death induced by endoplasmic reticulum stress

Raffaella Iurlaro et al.

FEBS JOURNAL (2016)

Review Clinical Neurology

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

Wiep Scheper et al.

ACTA NEUROPATHOLOGICA (2015)

Article Biochemistry & Molecular Biology

XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans

Mahender B. Dewal et al.

CHEMISTRY & BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Glycoprotein Quality Control and Endoplasmic Reticulum Stress

Qian Wang et al.

MOLECULES (2015)

Article Neurosciences

Marinesco-Sjogren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS

Audrey Filezac de L'Etang et al.

NATURE NEUROSCIENCE (2015)

Review Biochemistry & Molecular Biology

N-linked protein glycosylation in the ER

Markus Aebi

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Cell Biology

Glycosylation-independent ERAD pathway serves as a backup system under ER stress

Ryo Ushioda et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

Article Genetics & Heredity

Activation of elements in HERV-W family by caffeine and aspirin

Chunlan Liu et al.

VIRUS GENES (2013)

Article Cell Biology

Endoplasmic Reticulum Structure and Interconnections with Other Organelles

Amber R. English et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Multidisciplinary Sciences

A novel human endogenous retroviral protein inhibits cell-cell fusion

Jun Sugimoto et al.

SCIENTIFIC REPORTS (2013)

Review Psychiatry

Finding the needle in the haystack: A review of microarray gene expression research into schizophrenia

Nishantha Kumarasinghe et al.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2012)

Editorial Material Biochemistry & Molecular Biology

Unfolded protein response

Stewart Siyan Cao et al.

CURRENT BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Glycosylation of the Sodium Channel β4 Subunit is Developmentally Regulated and Involves in Neuritic Degeneration

Ting-tig Zhou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

Review Endocrinology & Metabolism

Crosstalk between Advanced Glycation and Endoplasmic Reticulum Stress: Emerging Therapeutic Targeting for Metabolic Diseases

Christina Piperi et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Review Biochemistry & Molecular Biology

Human endogenous retroviruses and multiple sclerosis: Innocent bystanders or disease determinants?

Joseph M. Antony et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Review Biotechnology & Applied Microbiology

A Review of the Mammalian Unfolded Protein Response

Anirikh Chakrabarti et al.

BIOTECHNOLOGY AND BIOENGINEERING (2011)

Article Neurosciences

Impaired ATF6 alpha processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease

Maria Rosario Fernandez-Fernandez et al.

NEUROBIOLOGY OF DISEASE (2011)

Article Biochemistry & Molecular Biology

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

Jin Hwan Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2010)

Article Biochemistry & Molecular Biology

N-Glycosylation of ATF6β Is Essential for Its Proteolytic Cleavage and Transcriptional Repressor Function to ATF6α

Dongyin Guan et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Article Neurosciences

Molecular profiles of schizophrenia in the CNS at different stages of illness

Sujatha Narayan et al.

BRAIN RESEARCH (2008)

Article Multidisciplinary Sciences

Up-regulation of a cellular protein at the translational level by a retrovirus

Fayth K. Yoshimura et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Genetics & Heredity

Associations of ATF4 gene polymorphisms with schizophrenia in male patients

Mei Qu et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2008)

Article Biochemistry & Molecular Biology

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

Nica M. Borradaile et al.

JOURNAL OF LIPID RESEARCH (2006)

Article Neurosciences

Insertional polymorphism of endogenous retrovirus HERV-K115 in schizophrenia

Takeshi Otowa et al.

NEUROSCIENCE LETTERS (2006)

Article Biochemistry & Molecular Biology

Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response

M Hong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology

F Mallet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Clinical Neurology

Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population

C Kakiuchi et al.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2004)

Article Biochemistry & Molecular Biology

A case-control study provides evidence of association for a functional polymorphism-197C/G in XBP1 to schizophrenia and suggests a sex-dependent effect

WY Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Review Biochemistry & Molecular Biology

Roles of N-linked glycans in the endoplasmic reticulum

A Helenius et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Opposing roles for ATF6α and ATF6β in endoplasmic reticulum stress response gene induction

DJ Thuerauf et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia

H Karlsson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Regulated translation initiation controls stress-induced gene expression in mammalian cells

HP Harding et al.

MOLECULAR CELL (2000)