More's the Same-Multiple Hosts Do Not Select for Broader Host Range Phages

Article Biotechnology & Applied Microbiology

Lytic bacteriophages UFJF_PfDIW6 and UFJF_PfSW6 prevent Pseudomonas fluorescens growth in vitro and the proteolytic-caused spoilage of raw milk during chilled storage

Edilane Cristina do Nascimento et al.

Summary: The study isolated and characterized P. fluorescens-infecting phages, which showed high specificity and effectiveness in reducing bacterial counts and delaying protein degradation during cold storage.

FOOD MICROBIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Expansion of the Plaquing Host Range and Improvement of the Absorption Rate of a T5-like Salmonella Phage by Altering the Long Tail Fibers

Jing Zhang et al.

Summary: This study successfully expanded the host range of a T5-like phage by editing its pb1 part. These findings suggest that the pb1 part may be the primary determinant of host specificity for some T5-like phages.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2022)

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Review Microbiology

Phage therapy as strategy to face post-antibiotic era: a guide to beginners and experts

Sabrina Royer et al.

Summary: Interest in the therapeutic use of bacteriophages (phages) has increased in recent years, driven by the antimicrobial resistance crisis. This review aims to summarize important studies on the efficacy and versatility of phage therapy, highlighting its potential as a promising route in the treatment of infections caused by multidrug-resistant pathogens. Standardized clinical trials using monoclonal or polyclonal phages, alone or in combination with antimicrobials, are crucial to determine the real potential of these treatments in clinical practice.

ARCHIVES OF MICROBIOLOGY (2021)

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Article Ecology

Host diversity slows bacteriophage adaptation by selecting generalists over specialists

Duhita G. Sant et al.

Summary: Research shows that increasing host strain diversity in cocultures slows down viral adaptation rates and selects for lower-fitness generalists over higher-fitness specialists. Evolved phage with more hosts are more likely to be generalists, and the addition of more potential hosts can select for low-fitness generalists over high-fitness specialists.

NATURE ECOLOGY & EVOLUTION (2021)

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Article Ecology

Spatial patterns in phage-Rhizobium coevolutionary interactions across regions of common bean domestication

Jannick Van Cauwenberghe et al.

Summary: Through the study of four phage-Rhizobium communities in Mexico and Argentina, it was found that both phage and host diversity are spatially structured. Results showed that phage local adaptation and host maladaptation play key roles in shaping phage-host interactions. The study also revealed a nested network of interactions between phages and hosts, with their genetic identity and geographic origin influencing the interactions.

ISME JOURNAL (2021)

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Article Virology

T4-like Bacteriophages Isolated from Pig Stools Infect Yersinia pseudotuberculosis and Yersinia pestis Using LPS and OmpF as Receptors

Mabruka Salem et al.

Summary: The Yersinia bacteriophages fPS-2, fPS-65, and fPS-90 isolated from pig stools exhibit relatively wide host ranges and genetic diversity in terms of genome structure and receptor recognition. The study also revealed the genetic mutations in phage-resistant mutants and the successful complementation of these mutations by introducing wild-type genes. The host recognition was assigned to a specific protein, Gp38, which plays a key role in binding to the host cells.

VIRUSES-BASEL (2021)

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Review Chemistry, Medicinal

The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?

Ahmad Y. Hassan et al.

Summary: Bacteriophages have emerged as a legitimate alternative antibacterial agent, with the potential to contribute greatly to bacterial evolution through interactions with mobile genetic elements. They also show promise in therapeutic and biocontrol applications in medical, agricultural, and food processing settings, as well as in the development of rapid, sensitive, and specific biosensors for various bacterial targets. Their bioengineering capabilities hold great potential in improving adaptability and effectiveness as biocontrol and detection tools.

PHARMACEUTICALS (2021)

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Review Multidisciplinary Sciences