4.6 Article

Transcriptional Reprogramming of Autographa Californica Multiple Nucleopolyhedrovirus Chitinase and Cathepsin Genes Enhances Virulence

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Mature viral cathepsin is required for release of viral occlusion bodies from Autographa californica multiple nucleopolyhedrovirus-infected cells

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Summary: The protease activity of cathepsin in Autographa californica multiple nucleopolyhedrovirus is crucial for efficient release of chitinase and cathepsin enzymes, as well as for the release of progeny OBs. This study suggests an important relationship between baculovirus-induced cell lysis, maturation of cathepsin, and the cellular release of enzymes and OBs.

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