☆ 4.6 Review

Updates on global epidemiology, risk and prognostic factors of gastric cancer

WORLD JOURNAL OF GASTROENTEROLOGY (2023)

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Article Oncology

Gastric Cancer, Version 2.2022

Jaffer A. Ajani et al.

Summary: Gastric cancer is the third leading cause of cancer-related deaths worldwide, with over 95% being adenocarcinomas. It is often diagnosed at an advanced stage, leading to a poor prognosis. However, systemic therapy can alleviate symptoms, improve survival, and enhance quality of life. The implementation of biomarker testing has significantly impacted clinical practice and patient care. Targeted therapies have shown encouraging results in clinical trials. Palliative management is recommended for patients with unresectable or metastatic cancer.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2022)

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Review Oncology

Immune evasion mechanisms and therapeutic strategies in gastric cancer

En-Si Ma et al.

Summary: This review systematically summarizes the intricate crosstalk between gastric cancer cells and immune cells, and how gastric cancer cells alter immune cells to create an immunosuppressive microenvironment. It also highlights the promising survival advantages of immune checkpoint inhibitor-based immunotherapies in gastric cancer patients.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer

Kohei Shitara et al.

Summary: In patients with gastro-oesophageal adenocarcinoma, nivolumab plus chemotherapy has shown superior overall survival compared to chemotherapy alone.

NATURE (2022)

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Article Oncology

Microbiota and gastric cancer

Emilie Bessede et al.

Summary: The discovery of Helicobacter pylori in 1982 led to a shift in understanding the stomach as a sterile organ. Further research revealed that the stomach contains a diverse microbiota, with H. pylori being the essential species that influences the richness and evenness of other bacterial communities. H. pylori is now recognized as the main risk factor for gastric cancer, particularly the strains carrying the cag pathogenicity island and the CagA oncoprotein. However, there is a need to consider other factors from the host and environment in explaining the differences between those infected with H. pylori and those developing gastric cancer. Studies have shown differences in the gastric microbiota at various stages of gastric premalignant and malignant lesions, indicating reduced microbial diversity and an increase in intestinal commensals with nitrosative functions. The role of other microorganisms, such as the Epstein-Barr virus and mycobiota, also needs further exploration. Animal models have provided insights into the role of different gastric microbiota apart from H. pylori.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Nutrition & Dietetics

Diet and Risk of Gastric Cancer: An Umbrella Review

Emmanouil Bouras et al.

Summary: In this Umbrella Review, the study provides an overview and evaluation of the associations of diet-related exposures with the risk of gastric cancer. The findings suggest that heavy alcohol consumption, salted fish consumption, high waist circumference, and unhealthy lifestyle choices are positively associated with gastric cancer, while maintaining a normal body weight and adopting a healthy lifestyle can reduce the risk. The quality of most meta-analyses included in the review is medium-to-high.

NUTRIENTS (2022)

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Review Surgery

Surgical Management of Gastric Cancer A Review

George Z. Li et al.

Summary: Surgery is crucial in the management of gastric cancer at all stages. Early gastric cancer patients with low risk of lymph node metastasis can potentially be cured with endoscopic therapy or surgery alone. Patients with later-stage localized gastric cancer benefit from extensive lymphadenectomy and multimodality therapy. Ongoing studies are investigating novel surgical approaches and peritoneal-directed therapies.

JAMA SURGERY (2022)

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Review Immunology

Recent Progress and Future Perspectives of Immunotherapy in Advanced Gastric Cancer

Xin Jin et al.

Summary: Gastric carcinoma is a common form of solid tumor and is the third leading cause of death worldwide. The lack of obvious symptoms makes it difficult to detect gastric cancer at earlier stages, leading to a poor prognosis. However, recent advances in understanding the microenvironment of cancer have significantly promoted the development of immunotherapy for advanced gastric cancer. Immunotherapy has shown robust efficacy and tolerable toxicity compared to traditional therapies, making it a popular novel strategy for the treatment of advanced gastric cancer.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Integrative & Complementary Medicine

Explore and Analyze the Composition and Characteristics of Intestinal Microbiota between Gastric Cancer Patients and Healthy People

Fang He et al.

Summary: Gastric cancer has an impact on the composition of intestinal microbiota, leading to changes in the relative abundance of certain microbial groups. This study found that patients with gastric cancer had lower relative abundance of intestinal flora closely related to gastric cancer, while other microbial groups showed increased relative abundance.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Microbial Proteins in Stomach Biopsies Associated with Gastritis, Ulcer, and Gastric Cancer

Shahid Aziz et al.

Summary: Through studying the microbiome in biopsies of patients with gastroduodenal diseases, it was found that more abundant microbial proteins were present in patients with gastritis, and species-specific bacterial proteins were detected, providing insights into the role of microbes in gastric inflammation.

MOLECULES (2022)

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Article Multidisciplinary Sciences

Diagnostic performances of pepsinogens and gastrin-17 for atrophic gastritis and gastric cancer in Mongolian subjects

Ganchimeg Dondov et al.

Summary: This study evaluated the levels of pepsinogens and gastrin-17 in Mongolian individuals and determined their diagnostic performance for gastric cancer and chronic atrophic gastritis. The study found that combinations of biomarkers with risk factors could improve diagnostic accuracy.

PLOS ONE (2022)

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Review Oncology

Current cancer burden in China: epidemiology, etiology, and prevention

Maomao Cao et al.

Summary: Cancer has become the leading cause of death in China, with significant changes in cancer epidemiology. Lung, colorectal, and gastric cancers are the most common types, while lung, liver, and stomach cancers are the deadliest. The 5-year survival rate for cancer has significantly improved in recent decades. Modifiable risk factors for cancer development include infectious agents, smoking, alcohol consumption, obesity, unhealthful dietary habits, and inadequate physical activity. The Chinese government has made efforts to reduce the cancer burden.

CANCER BIOLOGY & MEDICINE (2022)

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Review Oncology

Advances in molecular biomarkers research and clinical application progress for gastric cancer immunotherapy

Hongzhen Cai et al.

Summary: Gastric cancer is a global health concern with high morbidity and mortality rates. Immunotherapy, targeting molecules such as PD-1, has become a first-line option for certain conditions, aiming to activate T cells and improve treatment efficacy.

BIOMARKER RESEARCH (2022)

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Article Oncology

National guidelines for diagnosis and treatment of gastric cancer 2022 in China (English version) National Health Commission of the People's Republic of China

Jiafu Ji et al.

CHINESE JOURNAL OF CANCER RESEARCH (2022)

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Article Oncology

Epidemiology of Gastric Cancer in Korea: Trends in Incidence and Survival Based on Korea Central Cancer Registry Data (1999-2019)

Sin Hye Park et al.

Summary: This study investigated the trends of gastric cancer in Korea and found a decrease in the incidence and mortality rates, as well as changes in tumor stage and treatment methods. Over the past 20 years, the situation of gastric cancer in Korea has changed, and these findings provide important information for understanding the current status of gastric cancer.

JOURNAL OF GASTRIC CANCER (2022)

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Review Biochemistry & Molecular Biology

Advances in clinical immunotherapy for gastric cancer

Kexin Li et al.

Summary: Gastric cancer is a highly malignant cancer with increasing incidence worldwide, ranking among the top five malignant tumors in terms of incidence and mortality. Immunotherapy, as a breakthrough in cancer treatment, has shown to be effective in gastric cancer treatment, especially when used in combination with other modalities.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Biochemistry & Molecular Biology

Alcohol consumption and risk of stomach cancer: A meta-analysis

Wenting Deng et al.

Summary: The study revealed a significant association between alcohol consumption and increased risk of stomach cancer. Heterogeneity in results across different regions and subsites of stomach cancer indicates potential factors such as smoking rates, Helicobacter pylori infection, obesity, and genetic susceptibility. The dose-response analysis showed that higher daily alcohol intake is correlated with a higher risk of stomach cancer.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Oncology

Current treatment and recent progress in gastric cancer

Smita S. Joshi et al.

Summary: Gastric cancer is a common cause of cancer death worldwide, with treatment options including systemic chemotherapy, radiotherapy, surgery, immunotherapy, and targeted therapy. Classification and biomarkers for gastric cancer help in personalized therapy and identifying populations most likely to benefit from immunotherapy and targeted therapy.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Multidisciplinary Sciences

The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer

Yelena Y. Janjigian et al.

Summary: The study results demonstrate that adding pembrolizumab to trastuzumab and chemotherapy significantly reduces tumor size, induces complete responses in some patients, and improves objective response rate in HER2-positive gastric or gastro-oesophageal junction adenocarcinoma.

NATURE (2021)

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Review Pathology

Immunotherapy of gastric cancer: Past, future perspective and challenges

Jun Xie et al.

Summary: Gastric cancer is the third leading cause of deaths and the fifth most common cancers worldwide. Traditional treatment approaches include chemotherapy, radiation, surgery, and targeted therapy. Immunotherapy has shown promising results, but the prognosis remains poor.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Review Surgery

Immunotherapeutic advances in gastric cancer

Akira Yoneda et al.

Summary: Immunotherapy shows promising potential in the treatment of gastric cancer, including the use of immune checkpoint inhibitors, CAR-T cells, and tumor vaccines. Clinical trials have demonstrated improved survival times and objective response rates for gastric cancer patients undergoing immunotherapy.

SURGERY TODAY (2021)

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Article Oncology

Risk Factors of Lymph Node Metastasis and Its Prognostic Significance in Early Gastric Cancer: A Multicenter Study

Jinfeng Wang et al.

Summary: The study of 611 EGC patients identified risk factors for LNM including depth of invasion, tumor diameter, and morphological ulceration. Tumor location in the proximal third of the stomach and morphological ulceration were significantly associated with group 2 LNM. The 5-year survival rate decreased as the number of positive nodes increased, and 15 lymph node dissection and D2 radical operation are recommended for high risk patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Treatment Patterns and Outcomes in Chinese Patients with Gastric Cancer by HER2 Status: A Noninterventional Registry Study (EVIDENCE)

Shukui Qin et al.

Summary: The study aimed to evaluate the safety and effectiveness of trastuzumab plus chemotherapy in Chinese patients with HER2-positive metastatic gastric cancer. Results showed that trastuzumab treatment improved patients' overall survival and progression-free survival, with a safety profile consistent with previous knowledge.

ONCOLOGIST (2021)

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Article Immunology

Major Histocompatibility Complex Class I-Related Chain A (MICA) Allelic Variants Associate With Susceptibility and Prognosis of Gastric Cancer

Karen Toledo-Stuardo et al.

Summary: This study revealed the association between MICA gene polymorphisms and susceptibility and prognosis of gastric cancer. Different MICA alleles were found to be significantly correlated with the risk and survival rates of gastric cancer patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial

Yelena Y. Janjigian et al.

Summary: Nivolumab plus chemotherapy showed superior overall survival and progression-free survival compared to chemotherapy alone in previously untreated patients with advanced gastric, gastro-oesophageal junction, or oesophageal adenocarcinoma, indicating it as a new standard first-line treatment option with acceptable safety profile.

LANCET (2021)

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Article Oncology

Regional and racial disparity in proximal gastric cancer survival outcomes 1996-2016: Results from SEER and China National Cancer Center database

Lulu Zhao et al.

Summary: This study found that racial factors independently influenced the overall survival prognosis of PGC patients in both China and the US, with Black (HR=1.376) and White (HR=1.262) ethnicities showing poorer survival compared to Chinese ethnicity. Even in the US subgroup, Chinese PGC patients demonstrated better prognosis in the same region.

CANCER MEDICINE (2021)

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Article Medicine, General & Internal

Global Incidence and Mortality of Gastric Cancer, 1980-2018

Martin C. S. Wong et al.

Summary: This study evaluated the incidence and mortality trends of gastric cancer globally from 1980 to 2018, showing a decrease in overall incidence and mortality rates. However, there is an increasing incidence of gastric cancer in younger populations in some countries, emphasizing the importance of preventive strategies for this age group.

JAMA NETWORK OPEN (2021)

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Review Oncology

Screening for gastric cancer in China: Advances, challenges and visions

Xiaohan Fan et al.

Summary: Gastric cancer is a major cancer in China and around the world, with government-funded national screening programs being developed. Endoscopic screening for GC is effective but invasive, prompting the need for noninvasive methods. Biomarkers like pepsinogen, gastrin, and Helicobacter pylori antibodies have been proposed for risk stratification in high-risk populations. More research is needed to inform policymakers on appropriate screening age, intervals, novel biomarkers, and health economics in China.

CHINESE JOURNAL OF CANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Progress of Gastric Cancer Surgery in the era of Precision Medicine

Yumin Wang et al.

Summary: The development of gastric cancer surgery now focuses on precision, standardization, and individualized treatment, utilizing modern technology and comprehensive treatment methods, along with artificial intelligence and big data technology to improve the transformation of medical evidence.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Gastroenterology & Hepatology

Burden of Gastric Cancer

Aaron P. Thrift et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Review Nutrition & Dietetics

The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions

Steven K. Clinton et al.

JOURNAL OF NUTRITION (2020)

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Review Medicine, General & Internal

Recent progress in Helicobacter pylori treatment

Yi Hu et al.

CHINESE MEDICAL JOURNAL (2020)

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Article Gastroenterology & Hepatology

Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles

Pande Putu Erawijantari et al.

GUT (2020)

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Article Gastroenterology & Hepatology

Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035

Melina Arnold et al.

GUT (2020)

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Review Immunology

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

Ling Wu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Immune-related adverse events of checkpoint inhibitors

Manuel Ramos-Casals et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Review Oncology

Gastric cancer: a comprehensive review of current and future treatment strategies

Rachel E. Sexton et al.

CANCER AND METASTASIS REVIEWS (2020)

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Article Biotechnology & Applied Microbiology

Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer

Juan Wu et al.

DISEASE MARKERS (2020)

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Article Medicine, General & Internal

Gastric cancer

Elizabeth C Smyth et al.

LANCET (2020)

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Article Public, Environmental & Occupational Health

Determinant Factors on Differences in Survival for Gastric Cancer Between the United States and Japan Using Nationwide Databases

Yuri Ito et al.

JOURNAL OF EPIDEMIOLOGY (2020)

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Article Oncology

Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer

Hua Jiang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

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Article Oncology

Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer

Hua Jiang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

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Article Oncology

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer

Jiang Lv et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Medicine, Research & Experimental

Engineering and Design of Chimeric Antigen Receptors

Sonia Guedan et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2019)

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Review Gastroenterology & Hepatology

Precision surgical approach with lymph-node dissection in early gastric cancer

Shinichi Kinami et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Review Medicine, Research & Experimental

Recent Advances in the Surgical Treatment of Advanced Gastric Cancer: A Review

Zhaoyang Tan

MEDICAL SCIENCE MONITOR (2019)

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Review Oncology

Updates on Management of Gastric Cancer

Fabian M. Johnston et al.

CURRENT ONCOLOGY REPORTS (2019)

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Article Oncology

Cancer targeting by TCR gene-engineered T cells directed against Kita-Kyushu Lung Cancer Antigen-1

Bridget Marcinkowski et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Gastroenterology & Hepatology

Epidemiology of gastric cancer: global trends, risk factors and prevention

Prashanth Rawla et al.

GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY (2019)

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Article Gastroenterology & Hepatology

Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota

Rui M. Ferreira et al.

GUT (2018)

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Article Cell Biology

Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo

Yanjing Song et al.

PROTEIN & CELL (2018)

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Article Medical Laboratory Technology

The rs2839698 Single Nucleotide Polymorphism of lncRNA H19 is Associated with Post-Operative Prognosis in T3 Gastric Adenocarcinoma

Wenyuan Wang et al.

CLINICAL LABORATORY (2018)

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Article Oncology

The Changing Face of Noncardia Gastric Cancer Incidence Among US Non-Hispanic Whites

William F. Anderson et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

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Article Multidisciplinary Sciences

Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer

Minsung Kim et al.

PLOS ONE (2018)

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Article Biotechnology & Applied Microbiology

Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer

Xuefeng Yu et al.

ONCOTARGETS AND THERAPY (2018)

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Article Oncology

Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015

Kyu-Won Jung et al.

CANCER RESEARCH AND TREATMENT (2018)

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Article Oncology

The Changing Face of Noncardia Gastric Cancer Incidence Among US Non-Hispanic Whites

William F. Anderson et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

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Article Public, Environmental & Occupational Health

Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries

Hongmei Zeng et al.

LANCET GLOBAL HEALTH (2018)

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Review Immunology

Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive immune Repertoires

Enkelejda Miho et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Oncology

Gastric cancer: epidemiology, prevention, classification, and treatment

Robert Sitarz et al.

CANCER MANAGEMENT AND RESEARCH (2018)

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Article Oncology

Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer Phase 2 Clinical KEYNOTE-059 Trial

Charles S. Fuchs et al.

JAMA ONCOLOGY (2018)

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Article Oncology

Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment

Kelong Tao et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2018)

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Article Oncology

CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer

Yelena Y. Janjigian et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Review Oncology

Progress of preoperative and postoperative radiotherapy in gastric cancer

Nan Zhang et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2018)

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Article Oncology

IL-8-251T>A (rs4073) Polymorphism Is Associated with Prognosis in Gastric Cancer Patients

Patricio Gonzalez-Hormazabal et al.

ANTICANCER RESEARCH (2018)

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Article Oncology

Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients

Akihito Kawazoe et al.

GASTRIC CANCER (2017)

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Article Oncology

Global patterns and trends in stomach cancer incidence: Age, period and birth cohort analysis

Ganfeng Luo et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Oncology

Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium

Matteo Rota et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Oncology

The role of adjuvant platinum-based chemotherapy in esophagogastric cancer patients who received neoadjuvant chemotherapy prior to definitive surgery

John H. Saunders et al.

JOURNAL OF SURGICAL ONCOLOGY (2017)

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Article Medicine, General & Internal

Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial

Yoon-Koo Kang et al.

LANCET (2017)

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Review Gastroenterology & Hepatology

Molecular mimicry in Helicobacter pylori infections

Magdalena Chmiela et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

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Review Biotechnology & Applied Microbiology

Immunotherapeutic Strategies for Gastric Carcinoma: A Review of Preclinical and Clinical Recent Development

Mohamed Abozeid et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Review Oncology

Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer

Shyam Singh et al.

JOURNAL OF ONCOLOGY (2017)

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Review Medicine, General & Internal

Chemotherapy for advanced gastric cancer

Anna Dorothea Wagner et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2017)

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Article Oncology

Phase I Study of Neoadjuvant Chemotherapy with Capecitabine and Oxaliplatin for Locally Advanced Gastric Cancer

Hironaga Satake et al.

ANTICANCER RESEARCH (2017)

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Article Oncology

Efficacy of Sequential Ipilimumab Monotherapy versus Best Supportive Care for Unresectable Locally Advanced/Metastatic Gastric or Gastroesophageal Junction Cancer

Yung-Jue Bang et al.

CLINICAL CANCER RESEARCH (2017)

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Review Medicine, Research & Experimental

Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts

Jessica Hartmann et al.

EMBO MOLECULAR MEDICINE (2017)

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Review Gastroenterology & Hepatology

Sex-differences in the prevalence of Helicobacter pylon infection in pediatric and adult populations: Systematic review and meta-analysis of 244 studies

Abdulrazak Ibrahim et al.

DIGESTIVE AND LIVER DISEASE (2017)

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Review Biochemistry & Molecular Biology

The Principles of Engineering Immune Cells to Treat Cancer

Wendell A. Lim et al.

CELL (2017)

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Article Oncology

Cancer incidence and mortality in China in 2013: an analysis based on urbanization level

Wanqing Chen et al.

CHINESE JOURNAL OF CANCER RESEARCH (2017)

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Article Oncology

Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study

Didier Meulendijks et al.

INVESTIGATIONAL NEW DRUGS (2016)

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Article Oncology

Clinicopathological Variation of Lauren Classification in Gastric Cancer

Yun-Chi Chen et al.

PATHOLOGY & ONCOLOGY RESEARCH (2016)

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Article Surgery

Multicenter Prospective Comparative Study of Robotic Versus Laparoscopic Gastrectomy for Gastric Adenocarcinoma

Hyoung-Il Kim et al.

ANNALS OF SURGERY (2016)

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Article Oncology

Multimodality Therapy Improves Survival in Resected Early Stage Gastric Cancer in the United States

Jashodeep Datta et al.

ANNALS OF SURGICAL ONCOLOGY (2016)

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Review Medicine, Research & Experimental

The clinicopathologic significance of estrogen receptors in human gastric carcinoma

M. Wesolowska et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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Article Oncology

Optimal regimen of trastuzumab in combination with oxaliplatin/capecitabine in first-line treatment of HER2-positive advanced gastric cancer (CGOG1001): a multicenter, phase II trial

Jifang Gong et al.

BMC CANCER (2016)

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Article Surgery

Prognostic risk factors of early gastric cancer-a western experience

Thomas Haist et al.

LANGENBECKS ARCHIVES OF SURGERY (2016)

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Article Multidisciplinary Sciences

The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients

Minghui Zhang et al.

SCIENTIFIC REPORTS (2016)

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Review Public, Environmental & Occupational Health

Dietary intakes of citrus fruit and risk of gastric cancer incidence: an adaptive meta-analysis of cohort studies

Jong-Myon Bae et al.

EPIDEMIOLOGY AND HEALTH (2016)

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Article Oncology

Comparison of Gastric Cancer Survival Between Caucasian and Asian Patients Treated in the United States: Results from the Surveillance Epidemiology and End Results (SEER) Database

Jiping Wang et al.

ANNALS OF SURGICAL ONCOLOGY (2015)

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Review Biotechnology & Applied Microbiology

Manufacture of T cells using the Sleeping Beauty system to enforce expression of a CD19-specific chimeric antigen receptor

H. Singh et al.

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Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies

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Prevalence of Helicobacter pylori Infection Worldwide: A Systematic Review of Studies with National Coverage

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Prediction of Cancer Incidence and Mortality in Korea, 2014

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NY-ESO-1 antibody as a novel tumour marker of gastric cancer

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The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies

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Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project

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The association of cigarette smoking with gastric cancer: the multiethnic cohort study

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The blockade of immune checkpoints in cancer immunotherapy

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Comparison of Gastric Cancer Survival Following R0 Resection in the United States and Korea Using an Internationally Validated Nomogram

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Alcohol and Tobacco Use in Relation to Gastric Cancer: A Prospective Study of Men in Shanghai, China

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Modulation of Lymphocyte Regulation for Cancer Therapy: A Phase II Trial of Tremelimumab in Advanced Gastric and Esophageal Adenocarcinoma

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

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Smoking and gastric cancer: systematic review and meta-analysis of cohort studies

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P53 codon 72 polymorphism and gastric cancer: A meta-analysis of the literature

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Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer

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Smoking and alcohol drinking in relation to risk of gastric cancer: A population-based, prospective cohort study

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Highly salted food and mountain herbs elevate the risk for stomach cancer death in a rural area of Japan

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Familial clustering in subgroups of gastric cancer stratified by histology, age group and location

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Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women

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