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Novel biomarkers for early detection of gastric cancer

WORLD JOURNAL OF GASTROENTEROLOGY (2023)

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Article Gastroenterology & Hepatology

The role of circular RNA hsa_circ_0001789 as a diagnostic biomarker in gastric carcinoma

Hongpeng Lu et al.

Summary: A study found that hsa_circ_0001789 may serve as a novel biomarker for gastric cancer (GC). The expression levels of hsa_circ_0001789 were down-regulated in GC tissues and plasma samples, and were closely correlated with the malignant characteristics of GC. Compared to traditional tumor biomarkers, hsa_circ_0001789 showed better accuracy in predicting the stage of invasion, lymphatic metastasis, distant metastasis, and TNM stage of GC.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2023)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Medical Laboratory Technology

Combination of artificial intelligence-based endoscopy and miR148a methylation for gastric indefinite dysplasia diagnosis

Yoshiyuki Watanabe et al.

Summary: The study compared the accuracy of physician-performed endoscopy, artificial intelligence, and/or molecular markers in diagnosing GIN lesions, with board-certified endoscopic physicians group showing the highest accuracy, followed by a combination of AI and miR148a DNA methylation, and trainee endoscopists group having the lowest accuracy.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Biochemistry & Molecular Biology

Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer

Souvick Roy et al.

Summary: This study developed a non-invasive liquid biopsy method for early detection of gastric cancer by using circular RNAs (circRNAs) as biomarkers. The researchers identified a panel of 8 circRNAs that could reliably distinguish gastric cancer patients from non-disease controls, even in early-stage patients. The decreased expression of circRNAs in serum samples suggested their tumor specificity.

MOLECULAR CANCER (2022)

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Article Oncology

Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis

Yu Gong et al.

Summary: In this study, a novel circRNA-miRNA-mRNA network associated with gastric cancer pathogenesis was identified. This network may serve as a potential molecular biomarker and guide the development of therapeutic strategies for gastric cancer.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2022)

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Article Genetics & Heredity

Identifying Potential miRNA Biomarkers for Gastric Cancer Diagnosis Using Machine Learning Variable Selection Approach

Neda Gilani et al.

Summary: This study aimed to identify potential miRNAs for early-stage gastric cancer (GC) diagnosis. Using machine learning models and Boruta variable selection approach, hsa-miR-1343-3p was identified as a potential biomarker with high precision for predicting GC. Ontological analysis further confirmed the strong relationship between the identified miRNAs and cancer-associated genes and molecular events.

FRONTIERS IN GENETICS (2022)

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Article Multidisciplinary Sciences

Multi-omics reveals microbiome, host gene expression, and immune landscape in gastric carcinogenesis

Chan Hyuk Park et al.

Summary: In this study, the complex relationships between the intragastric microbiome and gastric mucosal gene expression in gastric carcinogenesis were analyzed using multi-omic approaches. Unique associations specific to different disease states were uncovered, providing new insights into the mechanisms underlying gastric cancer development. The study provides the most comprehensive description of microbial, host transcriptomic, and immune cell factors in the pathway of gastric carcinogenesis.

ISCIENCE (2022)

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Article Gastroenterology & Hepatology

Induction of Fibroblast Growth Factor Receptor 4 by Helicobacter pylori via Signal Transducer and Activator of Transcription 3 With a Feedforward Activation Loop Involving Steroid Receptor Coactivator Signaling in Gastric Cancer

Xing Zhang et al.

Summary: This study reveals the link between H pylori infection, inflammation, and FGFR4 activation, and identifies the important role of FGFR4 in gastric cancer development. The activation loop between FGFR4 and STAT3, mediated by steroid receptor coactivator, protects against H pylori-induced DNA damage and cell death.

GASTROENTEROLOGY (2022)

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Article Biochemistry & Molecular Biology

Gastric Cancer Pre-Stage Detection and Early Diagnosis of Gastritis Using Serum Protein Signatures

Shahid Aziz et al.

Summary: This study compared serum and tissue samples from patients with different gastroduodenal diseases to identify potential serum biomarkers for early gastric cancer diagnosis. It also identified specific serum markers for advanced gastric cancer independent of Helicobacter pylori infection. These findings have the potential to improve gastric cancer diagnostics.

MOLECULES (2022)

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Article Oncology

Comprehensive analysis of competitive endogenous RNAs network: Identification and validation of prediction model composed of mRNA signature and miRNA signature in gastric cancer

Wenshuang Ding et al.

Summary: This study established a ceRNA network for gastric cancer and identified mRNA and miRNA-based signatures that can be used for diagnosis and prognosis of gastric cancer.

ONCOLOGY LETTERS (2022)

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Review Genetics & Heredity

DNA Methylation: An Important Biomarker and Therapeutic Target for Gastric Cancer

Yunqing Zeng et al.

Summary: DNA methylation plays a significant role in the occurrence and development of gastric cancer, and research in this area is crucial for finding cancer biomarkers.

FRONTIERS IN GENETICS (2022)

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Article Oncology

Identification of circRNA-miRNA-Immune-Related mRNA Regulatory Network in Gastric Cancer

Zhenhai Wu et al.

Summary: This study constructed a regulatory network for ceRNA (circRNA-miRNA-immune-related mRNA) in gastric cancer (GC) and validated its significance in the development of GC.

FRONTIERS IN ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Identification of circRNA Biomarker for Gastric Cancer through Integrated Analysis

Md. Tofazzal Hossain et al.

Summary: This study suggests that circRNAs, specifically circCEACAM5 and circCOL1A1, may serve as potential biomarkers for the diagnosis and treatment of gastric cancer. The findings highlight the importance of circRNAs in the occurrence and development of gastric cancer.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Oncology

ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group

J. Pascual et al.

Summary: Circulating tumour DNA (ctDNA) assays conducted on plasma are proving to be valuable tools for identifying actionable mutations in patients with advanced cancer and for detecting molecular residual disease or relapse in early-stage cancer. However, tissue-based testing is still preferred due to the limitations of ctDNA assays.

ANNALS OF ONCOLOGY (2022)

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Article Oncology

Plasma thioredoxin reductase: a potential diagnostic biomarker for gastric cancer

Yinxing Zhu et al.

Summary: The study evaluates the diagnostic value of thioredoxin reductase 1 (TXNRD1) and finds that its overexpression is associated with poor prognosis in gastric cancer patients. Plasma thioredoxin reductase levels are significantly higher in gastric cancer patients compared to benign disease and healthy controls. The combined detection of thioredoxin reductase and routine tumor markers improves diagnostic efficacy and plasma thioredoxin reductase has the potential to monitor therapeutic efficacy.

CARCINOGENESIS (2022)

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Article Oncology

A new biomarker for the early diagnosis of gastric cancer: gastric juice- and serum-derived SNCG

Yangyang Pan et al.

Summary: This study aimed to investigate the potential of SNCG in gastric juice (GJ) and serum as a biomarker for early diagnosis of gastric cancer (GC). The levels of SNCG in GJ and serum samples were significantly higher in the GC group compared to the control groups. The expression of SNCG in GJ and serum was associated with tumor characteristics and drinking habits, and it is important for the diagnosis and prognosis of GC.

FUTURE ONCOLOGY (2022)

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Article Oncology

Isolation and Characterization of Extracellular Vesicles from Gastric Juice

Gleb O. Skryabin et al.

Summary: This study validates the presence of extracellular vesicles (EVs) in gastric juice (GJ) and demonstrates the feasibility of isolating EVs from GJ using ultracentrifugation. The study also reveals the heterogeneity and composition differences of GJ-derived EVs, and proposes the potential of using GJ-derived EVs as miRNA markers for gastric cancer (GC) screening.

CANCERS (2022)

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Review Oncology

Finding Waldo: The Evolving Paradigm of Circulating Tumor DNA (ctDNA)-Guided Minimal Residual Disease (MRD) Assessment in Colorectal Cancer (CRC)

Sakti Chakrabarti et al.

Summary: This article discusses how ctDNA technology can be used to guide treatment in patients with colorectal cancer (CRC) after curative surgery. ctDNA technology can detect residual cancer cells and be used to determine the need for adjuvant therapy.

CANCERS (2022)

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Article Oncology

Expression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer

Ke Xiao et al.

Summary: This study investigated the expression profile of serum Extracellular Vesicle circular RNAs (EV circRNAs) in gastric cancer (GC) patients and found that these circRNAs may serve as potential biomarkers for the diagnosis of GC.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Driver Gene Alterations in Malignant Progression of Gastric Cancer

Yuanqiang Dong et al.

Summary: Identifying driver genes is crucial in modern medical research, contributing to individualization and understanding the causes of cancer. This study used comprehensive gene expression and copy number analysis to identify mutation-based driver genes in gastric cancer (GC), finding prominent variations and candidate driver oncogenes associated with immune infiltration levels.

FRONTIERS IN ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Molecular Biomarkers in Cancer

Virinder Kaur Sarhadi et al.

Summary: Molecular cancer biomarkers are measurable molecular indicators that provide information about cancer risk, occurrence, and patient outcome. They can be detected in various samples using advanced detection technologies. Biomarkers have extensive clinical applications and can assist in decision-making and individualized targeted therapies.

BIOMOLECULES (2022)

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Article Multidisciplinary Sciences

Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer

Mary L. Stackpole et al.

Summary: Early cancer detection using cell-free DNA faces challenges of low tumor DNA fraction, molecular heterogeneity, and limited sample sizes. In this study, the authors developed a cost-effective method called cfMethyl-Seq to profile the methylome of cell-free DNA and detect and locate cancer. The approach achieved high sensitivity and accuracy for detecting and identifying the tissue-of-origin of various cancer types.

NATURE COMMUNICATIONS (2022)

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Review Oncology

Impact of Circulating Tumor DNA-Based Detection of Molecular Residual Disease on the Conduct and Design of Clinical Trials for Solid Tumors

Pashtoon M. Kasi et al.

Summary: The use of circulating tumor DNA (ctDNA) for detecting molecular residual disease (MRD) has the potential to significantly impact cancer management by enabling earlier detection of cancer recurrence. Numerous studies have shown that ctDNA-based MRD detection predicts recurrence with high sensitivity and specificity, often preceding standard imaging by up to 12 months. Recent developments include the use of ctDNA testing to enroll high-risk MRD-positive patients into clinical trials, leading to improved statistical power and potential reductions in trial duration. The use of ctDNA dynamics or clearance as a surrogate endpoint is also gaining support, offering further potential for shorter trial durations.

JCO PRECISION ONCOLOGY (2022)

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Article Gastroenterology & Hepatology

Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population

Jimmy Bok Yan So et al.

Summary: A serum 12-miRNA biomarker assay was developed and validated for gastric cancer detection, showing high sensitivity and specificity in clinical studies. The assay may be a cost-effective risk assessment tool for gastric cancer screening compared to current practices.

GUT (2021)

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Article Oncology

As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway

Shuo Ma et al.

Summary: CircPTPN22 is upregulated in gastric cancer tissues, cells, and plasma, and positively correlated with metastasis. It can serve as a diagnostic marker and predict patient prognosis. CircPTPN22 inhibits cell proliferation and metastasis through competitive binding of miRNAs to regulate the EMT pathway.

CANCER CELL INTERNATIONAL (2021)

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Article Medical Laboratory Technology

NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics

Yang Xiao et al.

Summary: This study identified NSDHL and NCEH1 as useful biomarkers for screening, diagnosis, and prognosis of patients with gastric cancer using iTRAQ-labeled quantitative proteomics. The combination of NSDHL and NCEH1 showed good performance in terms of sensitivity and specificity.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Oncology

Liquid biopsy enters the clinic - implementation issues and future challenges

Michail Ignatiadis et al.

Summary: The approval of liquid biopsy assays for detecting genetic alterations in plasma cell-free DNA has marked a tipping point for the clinical use of this technology, especially in patients with advanced-stage cancer. The next frontier is likely to be the systemic treatment of patients with 'ctDNA relapse' and other potential future applications include cancer screening and diagnosis.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Oncology

Exosome-based liquid biopsies in cancer: opportunities and challenges

W. Yu et al.

Summary: Liquid biopsy in cancer research has seen significant progress, with efforts focused on utilizing circulating tumor cells, circulating tumor DNA, and extracellular vesicles like exosomes. Exosomes, as part of the intercellular communication system, carry tumor-derived materials and can serve as stable biomarkers for early detection and monitoring of cancer.

ANNALS OF ONCOLOGY (2021)

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Article Oncology

Circulating serum exosomal miR-92a-3p as a novel biomarker for early diagnosis of gastric cancer

Xu Lu et al.

Summary: Gastric cancer (GC) is a common malignant tumor with high mortality. This study demonstrated that serum exosomal miR-92a-3p may serve as a novel tumor biomarker for improving diagnostic efficiency in GC. The expression of serum exosomal miR-92a-3p showed significant correlation with lymph node metastasis and tumor node metastasis stage in GC patients.

FUTURE ONCOLOGY (2021)

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Article Genetics & Heredity

A combination of methylation and protein markers is capable of detecting gastric cancer detection by combined markers

Jianbiao Xu et al.

Summary: Gastric cancer is the most common cancer type in the digestive system. A combination of mSEPT9, mRNF180, and CA724 showed promising potential for noninvasive early detection of gastric cancer, with the combination detecting 68.6% of cases. Blood mSEPT9 was found to be predictive for gastric cancer prognosis.

EPIGENOMICS (2021)

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Article Genetics & Heredity

Identification of Serum Circulating MicroRNAs as Novel Diagnostic Biomarkers of Gastric Cancer

Yunjin Yao et al.

Summary: This study identified three miRNAs with high sensitivity and specificity in distinguishing gastric cancer cases from non-cancer controls, suggesting their potential as biomarkers for gastric cancer screening.

FRONTIERS IN GENETICS (2021)

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Article Biochemistry & Molecular Biology

Exosomal miR-590-5p in Serum as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer

Guo-Dian Zheng et al.

Summary: The study found that the expression of exosomal miR-590-5p is associated with the clinical stage, infiltration depth, and ki-67 expression level of GC. A decrease in exosomal miR-590-5p expression is correlated with a decrease in overall survival rate. As an independent predictor, miR-590-5p may inhibit cell migration and invasion, potentially serving as a biomarker for early detection and prediction of GC.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Oncology

A novel combination of serum microRNAs for the detection of early gastric cancer

Seiichiro Abe et al.

Summary: This study aimed to identify serum miRNAs that can accurately differentiate early gastric cancer. Using a large cohort, a combination of four miRNAs was discovered to be a potential non-invasive diagnostic biomarker for EGC. Further confirmation through a multicenter prospective study is currently underway.

GASTRIC CANCER (2021)

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Review Biochemistry & Molecular Biology

Biomarkers for Gastric Cancer Screening and Early Diagnosis

Cristina Herrera-Pariente et al.

Summary: Gastric cancer is a common cancer worldwide, with early detection being crucial for improving clinical outcomes. Current screening programs are effective in high-incidence populations but not cost-effective in low-incidence populations, highlighting the need for new noninvasive biomarkers.

BIOMEDICINES (2021)

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Review Oncology

Liquid Biopsy: From Discovery to Clinical Application

Catherine Alix-Panabieres et al.

Summary: CTC and ctDNA have been recognized as promising biomarkers with various clinical applications, including early cancer detection and therapeutic monitoring. However, challenges such as standardization and validation of clinical effectiveness need to be addressed in this dynamic field of translational cancer research.

CANCER DISCOVERY (2021)

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Article Oncology

REMARRY and PURSUIT trials: liquid biopsy-guided rechallenge with anti-epidermal growth factor receptor (EGFR) therapy with panitumumab plus irinotecan for patients with plasma RAS wild-type metastatic colorectal cancer

Hiromichi Nakajima et al.

Summary: This trial aims to evaluate the dynamics of plasma RAS status in patients with RAS/BRAF V600E wild-type mCRC who have progressed after previous anti-EGFR therapy, and to assess the efficacy and safety of rechallenge therapy with panitumumab plus irinotecan in plasma RAS negative patients. Through biomarker analyses, the trial will help identify patients who could benefit from rechallenge with anti-EGFR mAb in addition to being plasma RAS negative.

BMC CANCER (2021)

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Article Oncology

Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric Cancer

Tomoko Jogo et al.

Summary: ctDNA sequencing is more effective in detecting FGFR2 amplification in patients with advanced gastric cancer compared to tissue analysis, and these patients may respond to FGFR inhibitors.

CLINICAL CANCER RESEARCH (2021)

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Article Oncology

LncRNA HCP5: A Potential Biomarker for Diagnosing Gastric Cancer

Shiyi Qin et al.

Summary: The study demonstrated that serum HCP5 has potential as a biomarker for early diagnosis of gastric cancer, with reliable repeatability and significant correlation between high expression and gastric cancer. When combined with existing tumor markers, HCP5 can significantly improve diagnostic sensitivity, showing higher specificity in gastric cancer compared to other cancer types.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Evaluation of the Diagnostic Potential of a Plasma Exosomal miRNAs Panel for Gastric Cancer

Jiajia Yang et al.

Summary: The study examines the diagnostic potential of plasma exosomal miR-195-5p and miR-211-5p for gastric cancer (GC). Results show that GC patients have elevated levels of these two miRNAs, which could be used as potential biomarkers for GC diagnosis and predicting tumor phenotype. Additionally, in vitro experiments demonstrate that miR-195-5p and miR-211-5p can enhance tumor invasion, migration, and proliferation while inhibiting cell apoptosis, highlighting their potential for clinical application.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Aberrant Non-Coding RNA Expressed in Gastric Cancer and Its Diagnostic Value

Zhilong Yu et al.

Summary: Recent studies have shown that non-coding RNAs (ncRNAs) may serve as novel biomarkers for predicting the occurrence and prognosis of gastric cancer. By analyzing the expression profiles of miRNA, lncRNA, and cirRNA in gastric cancer patients, it was found that these ncRNAs could potentially be promising molecular markers for the diagnosis and prognosis of gastric cancer.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Identification of Early Diagnostic and Prognostic Biomarkers via WGCNA in Stomach Adenocarcinoma

Ruoyue Tan et al.

Summary: This study identified potential biomarkers for early detection and prognosis of stomach adenocarcinoma (STAD) using Weighted Gene Co-expression Network Analysis (WGCNA) on RNA-Seq and clinical data from TCGA database. Five hub genes including MS4A1, THBS2, VCAN, PDGFRB, and KCNA3 were significantly dysregulated in stage-I STADs compared to normal stomach gland tissues, suggesting their potential as early diagnostic biomarkers. High expression of VCAN and PDGFRB were associated with poor prognosis of STAD, with Gene Ontology analysis indicating terms related to extracellular matrix and receptor ligand activity being significantly enriched in differentially expressed genes in STAD. Protein-protein network interaction analysis and Gene Set Enrichment Analysis further supported the key role of VCAN and PDGFRB in tumorigenesis.

FRONTIERS IN ONCOLOGY (2021)

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Article Medicine, General & Internal

Assessment of the Diagnostic Efficiency of a Liquid Biopsy Assay for Early Detection of Gastric Cancer

Daisuke Izumi et al.

Summary: This diagnostic study successfully established a novel microRNA-based signature for early detection of gastric cancer through a comprehensive biomarker discovery approach, which was retrospectively and prospectively validated in multicenter patient cohorts.

JAMA NETWORK OPEN (2021)

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Review Biochemical Research Methods

Uncovering the Depths of the Human Proteome: Antibody-based Technologies for Ultrasensitive Multiplexed Protein Detection and Quantification

Annie H. Ren et al.

Summary: Understanding advanced technologies for multiplexed ultrasensitive protein measurement is crucial, as these technologies now allow simultaneous quantification of thousands of proteins, helping researchers to elucidate the complex interactions among multiple proteins in disease mechanisms.

MOLECULAR & CELLULAR PROTEOMICS (2021)

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Article Oncology

Peripheral Blood-Based DNA Methylation of Long Non-Coding RNA H19 and Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promoters are Potential Non-Invasive Biomarkers for Gastric Cancer Detection

Dingtao Hu et al.

Summary: Using multiple online databases, we found that the mRNA expressions of H19 and MALAT1 in tissues were related to the occurrence of GC, and such expressions were associated with immune cell infiltration of GC and negatively correlated with DNA methylation levels of H19 and MALAT1. Statistically significant hypermethylation of H19 and MALAT1 promoters in GC patients was observed, and meaningful sensitivity and specificity of MALAT1 and H19 methylation in discriminating GC and HCs were found in both female and male groups, suggesting their potential as non-invasive biomarkers for GC diagnosis.

CANCER CONTROL (2021)

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Article Biochemistry & Molecular Biology

Abnormally expressed long noncoding RNA B3GALT5-AS1 may serve as a biomarker for the diagnostic and prognostic of gastric cancer

Wei Feng et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Medical Laboratory Technology

Exosomal long noncoding RNA lnc-GNAQ-6:1 may serve as a diagnostic marker for gastric cancer

Shibao Li et al.

CLINICA CHIMICA ACTA (2020)

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Article Medical Laboratory Technology

Plasma proteomics-based identification of novel biomarkers in early gastric cancer

Bin Zhou et al.

CLINICAL BIOCHEMISTRY (2020)

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Article Oncology

Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer

Wei Xu et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Gastroenterology & Hepatology

Association between the methylation of the STAT1 and SOCS3 in peripheral blood and gastric cancer

Qian Han et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Evaluation of C5orf66-AS1 as a Potential Biomarker for Predicting Early Gastric Cancer and Its Role in Gastric Carcinogenesis

Quan Zhou et al.

ONCOTARGETS AND THERAPY (2020)

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Article Cell Biology

Deep sequencing of circulating tumor DNA detects molecular residual disease and predicts recurrence in gastric cancer

Jian Yang et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

Feasibility of Plasma-Methylated SFRP2 for Early Detection of Gastric Cancer

Jin Miao et al.

CANCER CONTROL (2020)

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Article Genetics & Heredity

Combination of Four Serum Exosomal MiRNAs as Novel Diagnostic Biomarkers for Early-Stage Gastric Cancer

Shuli Tang et al.

FRONTIERS IN GENETICS (2020)

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Article Multidisciplinary Sciences

Microbiome analyses of blood and tissues suggest cancer diagnostic approach

Gregory D. Poore et al.

NATURE (2020)

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Article Oncology

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

M. C. Liu et al.

ANNALS OF ONCOLOGY (2020)

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Article Surgery

Circulating Exosomal Gastric Cancer-Associated Long Noncoding RNA1 as a Bioniarker for Early Detection and Monitoring Progression of Gastric Cancer A Multiphase Study

Xin Guo et al.

JAMA SURGERY (2020)

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Review Biochemistry & Molecular Biology

Systems Biology of Gastric Cancer: Perspectives on the Omics-Based Diagnosis and Treatment

Xiao-Jing Shi et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article Gastroenterology & Hepatology

HER2 gene assessment in liquid biopsy of gastric and esophagogastric junction cancer patients qualified for surgery

Anna Grenda et al.

BMC GASTROENTEROLOGY (2020)

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Article Biochemistry & Molecular Biology

The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer

Maria Alejandra Alarcon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Circulating exosomal small RNAs are promising non-invasive diagnostic biomarkers for gastric cancer

Lichen Ge et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Oncology

ctDNA as a cancer biomarker: A broad overview

Luciana Santos Pessoa et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Article Cell Biology

LncRNA SNHG17 promotes gastric cancer progression by epigenetically silencing of p15 and p57

Guohua Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Gastroenterology & Hepatology

Tumor-specific genetic aberrations in cell-free DNA of gastroesophageal cancer patients

Kristina Magaard Koldby et al.

JOURNAL OF GASTROENTEROLOGY (2019)

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Article Oncology

Clinical significance of serum miR-25 as a diagnostic and prognostic biomarker in human gastric cancer

Ying Kong et al.

CANCER BIOMARKERS (2019)

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Article Medical Laboratory Technology

Evaluating the diagnostic and prognostic value of serum long non-coding RNA CTC-497E21.4 in gastric cancer

Wei Zong et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Circulating microRNA-133, microRNA-17 and microRNA-25 in serum and its potential diagnostic value in gastric cancer

Parisa ZiaSarabi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Review Oncology

Detection of Minimal Residual Disease Using ctDNA in Lung Cancer: Current Evidence and Future Directions

Young Kwang Chae et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

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Article Pathology

Identification of diagnostic utility and molecular mechanisms of circulating miR-551b-5p in gastric cancer

Xiaomeng Jiang et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Article Biotechnology & Applied Microbiology

The Diagnostic and Prognostic Value of miR-200c in Gastric Cancer: A Meta-Analysis

Zong-Sheng Huang et al.

DISEASE MARKERS (2019)

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Article Environmental Sciences

Benthic ecological quality assessment of the Bohai Sea, China using marine biotic indices

Dapeng Ni et al.

MARINE POLLUTION BULLETIN (2019)

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Article Gastroenterology & Hepatology

Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer

Xiao-Liang Zhu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Article Cell Biology

Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric Cancer

Peng Zhang et al.

CELL REPORTS (2019)

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Review Medicine, General & Internal

Prediction of Chronic Atrophic Gastritis and Gastric Neoplasms by Serum Pepsinogen Assay: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy

Chang Seok Bang et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Oncology

Plasma long noncoding RNAs PANDAR, FOXD2-AS1, and SMARCC2 as potential novel diagnostic biomarkers for gastric cancer

Ziwei Yang et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Oncology

Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma

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Monitoring circulating tumor DNA by analyzing personalized cancer-specific rearrangements to detect recurrence in gastric cancer

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EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Long noncoding RNA ARHGAP27P1 inhibits gastric cancer cell proliferation and cell cycle progression through epigenetically regulating p15 and p16

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Serum Exosomal Long Noncoding RNA pcsk2-2:1 As A Potential Novel Diagnostic Biomarker For Gastric Cancer

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ONCOTARGETS AND THERAPY (2019)

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Potential diagnostic and prognostic value of plasma long noncoding RNA LINC00086 and miR-214 expression in gastric cancer

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CANCER BIOMARKERS (2019)

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Proteogenomic Characterization of Human Early-Onset Gastric Cancer

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CANCER CELL (2019)

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Review Oncology

Complexity of genome sequencing and reporting: Next generation sequencing (NGS) technologies and implementation of precision medicine in real life

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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

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The DNA methylation landscape in cancer

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DNA METHYLATION (2019)

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Review Genetics & Heredity

Current and future perspectives of liquid biopsies in genomics-driven oncology

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Serum microRNA-381: A Potential Marker for Early Diagnosis of Gastric Cancer

Ye Li et al.

YONSEI MEDICAL JOURNAL (2019)

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Droplet digital PCR-based circulating microRNA detection serve as a promising diagnostic method for gastric cancer

Gaoping Zhao et al.

BMC CANCER (2018)

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Article Cell Biology

A panel consisting of three novel circulating lncRNAs, is it a predictive tool for gastric cancer?

Jingjing Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Exosomal long noncoding RNA HOTTIP as potential novel diagnostic and prognostic biomarker test for gastric cancer

Rui Zhao et al.

MOLECULAR CANCER (2018)

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Article Biochemistry & Molecular Biology

Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer

Ling-Yun Lin et al.

MOLECULAR CANCER (2018)

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Review Oncology

Extracellular vesicles in cancer - implications for future improvements in cancer care

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NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Epigenetic Mechanisms and Events in Gastric Cancer-Emerging Novel Biomarkers

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PATHOLOGY & ONCOLOGY RESEARCH (2018)

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Detection and localization of surgically resectable cancers with a multi-analyte blood test

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SCIENCE (2018)

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Review Gastroenterology & Hepatology

Biomarkers of gastric cancer: Current topics and future perspective

Tasuku Matsuoka et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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DNA Methylation Status of the Interspersed Repetitive Sequences for LINE-1, Alu, HERV-E, and HERV-K in Trabeculectomy Specimens from Glaucoma Eyes

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Article Oncology

Methylation and Expression of Nonclustered Protocadherins Encoding Genes and Risk of Precancerous Gastric Lesions in a High-Risk Population

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CANCER PREVENTION RESEARCH (2018)

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Review Cell Biology

Infection-associated epigenetic alterations in gastric cancer: New insight in cancer therapy

Sadegh Fattahi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Biochemistry & Molecular Biology

The Biogenesis, Functions, and Challenges of Circular RNAs

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MOLECULAR CELL (2018)

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Article Oncology

Circulating long non-coding RNAs HULC and ZNFX1-AS1 are potential biomarkers in patients with gastric cancer

Hai-Peng Xian et al.

ONCOLOGY LETTERS (2018)

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Article Cell Biology

Long noncoding RNA LINC00978 promotes cancer growth and acts as a diagnostic biomarker in gastric cancer

Min Fu et al.

CELL PROLIFERATION (2018)

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Alu-based cell-free DNA: a novel biomarker for screening of gastric cancer

Chen Qian et al.

ONCOTARGET (2017)

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Clinical relevance of cell-free DNA in gastrointestinal tract malignancy

Yuan-Tzu Lan et al.

ONCOTARGET (2017)

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Article Multidisciplinary Sciences

miR-376c promotes carcinogenesis and serves as a plasma marker for gastric carcinoma

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PLOS ONE (2017)

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Review Multidisciplinary Sciences

Epigenetic plasticity and the hallmarks of cancer

William A. Flavahan et al.

SCIENCE (2017)

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Article Gastroenterology & Hepatology

Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer

Mei Huang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

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Promoter methylation of tumor-related genes as a potential biomarker using blood samples for gastric cancer detection

Jinfeng Wen et al.

ONCOTARGET (2017)

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Review Oncology

Liquid biopsies come of age: towards implementation of circulating tumour DNA

Jonathan C. M. Wan et al.

NATURE REVIEWS CANCER (2017)

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Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery

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GUT (2016)

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Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

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NUCLEIC ACIDS RESEARCH (2016)

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Noncoding RNAs in gastric cancer: Research progress and prospects

Meng Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Article Oncology

LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer

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ONCOTARGET (2016)

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BARHL2 Methylation Using Gastric Wash DNA or Gastric Juice Exosomal DNA is a Useful Marker For Early Detection of Gastric Cancer in an H-pylori-Independent Manner

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CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2016)

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Long noncoding RNAs: Novel insights into gastric cancer

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CANCER LETTERS (2015)

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Biology, detection, and clinical implications of circulating tumor cells

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EMBO MOLECULAR MEDICINE (2015)

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Review Biochemistry & Molecular Biology

MicroRNA biogenesis: regulating the regulators

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CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

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Alu and Sat alpha hypomethylation in Helicobacter pylori-infected gastric mucosae

Takeichi Yoshida et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

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The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile

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BMC MEDICAL GENOMICS (2008)

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