☆ 4.5 Review

Organoids technology for advancing the clinical translation of cancer nanomedicine

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2023)

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Review Oncology

Patient-derived xenograft models in hepatopancreatobiliary cancer

Binhua Pan et al.

Summary: Animal models are essential for evaluating human cancers and investigating anticancer drugs and prevention. In hepatopancreatobiliary cancer research, mouse models are widely used. While current CDX models have limitations, the emerging PDX model shows promise for precision cancer medicine in hepatopancreatobiliary cancer research.

CANCER CELL INTERNATIONAL (2022)

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Review Pharmacology & Pharmacy

Combination therapy based on targeted nano drug co-delivery systems for liver fibrosis treatment: a review

Liyue Zhou et al.

Summary: Liver fibrosis is a common liver disease that occurs before cirrhosis and hepatocellular carcinoma. The use of nano drug delivery systems and combination therapy shows promise in treating liver fibrosis by enhancing therapeutic effects and reducing side effects. It offers a new pathway for the future treatment of fibrosis.

JOURNAL OF DRUG TARGETING (2022)

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Review Biochemistry & Molecular Biology

A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives

Peng Liu et al.

Summary: Liposomes have been widely recognized as promising drug carriers due to their superior properties. This review discusses the liposomal drug products approved by FDA and EMA, providing valuable information on their critical chemistry and pharmaceutical technologies. Moreover, it summarizes the current regulatory guidance and future perspectives related to liposomal products.

MOLECULES (2022)

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Article Multidisciplinary Sciences

Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy

Yuling Xiao et al.

Summary: In this study, the authors demonstrate that combining CXCR4-targeted p53 mRNA nanoparticles with anti-PD-1 therapy effectively reverses immunosuppression and improves anti-tumor effects in hepatocellular carcinoma models.

NATURE COMMUNICATIONS (2022)

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Article Pharmacology & Pharmacy

Why 90 % of clinical drug development fails and how to improve it?

Duxin Sun et al.

Summary: Despite the implementation of many successful strategies, the majority of clinical drug development fails. This study suggests that current drug optimization strategies overlook tissue exposure/selectivity, leading to misleading drug candidate selection and impacting clinical efficacy/toxicity balance. The proposed structure-tissue exposure/selectivity-activity relationship (STAR) classification system aims to improve drug optimization and enhance the success rate of clinical drug development.

ACTA PHARMACEUTICA SINICA B (2022)

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Review Chemistry, Physical

Next-generation cancer organoids

Bauer L. LeSavage et al.

Summary: The translation discusses how organotypic models of patient-specific tumors are changing our understanding of cancer heterogeneity and personalized medicine. These models can preserve genetic, proteomic, morphological, and pharmacotypic features of the parent tumor in vitro, and offer genomic and environmental manipulation. However, current cancer organoid culture techniques are uncontrolled and irreproducible, hindering the acceleration of insights into patient care.

NATURE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Boosting ferroptosis via abplatin(iv) for treatment of platinum-resistant recurrent ovarian cancer

Wenwen Wang et al.

Summary: Four platinum(IV) prodrugs loaded with human serum albumin nanoparticles were developed and tested for their anticancer activity. Abplatin((iv)) showed the best efficacy in ovarian cancer cell lines and demonstrated enhanced antitumor effects in patient-derived models. It exhibited low systemic toxicity and high anticancer activity against platinum-resistant ovarian cancer, indicating its potential for clinical translation.

NANO TODAY (2022)

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Review Biotechnology & Applied Microbiology

The clinical progress of mRNA vaccines and immunotherapies

Ann J. Barbier et al.

Summary: The emergency use authorizations (EUAs) of mRNA-based vaccines against SARS-CoV-2 highlight the transformative potential of this nucleic acid technology. Clinical applications of mRNA have mainly focused on vaccines for infectious diseases and cancer, but there are challenges in using mRNA for immunotherapies. The past year has seen significant progress in the clinical development of mRNA therapies for COVID-19, as well as other diseases such as influenza, HIV, and cancer.

NATURE BIOTECHNOLOGY (2022)

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Review Instruments & Instrumentation

Current hurdles to the translation of nanomedicines from bench to the clinic

Snezana Dordevic et al.

Summary: The field of nanomedicine faces challenges in regulatory clarity and consistency. Developing nanomedicines requires considerations of critical quality attributes, appropriate analytical methods, important process parameters, and pre-clinical models. Close collaboration with regulatory agencies is advised to accelerate the development of future nanomedicines.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Review Chemistry, Multidisciplinary

Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis

Zerong Pei et al.

Summary: This review analyzes the development trend, main authors, and research hotspots of nanomedicine in the field of cancer, revealing that despite China having more publications than the United States, the United States still dominates this field. Moreover, the study identifies cancer nanomedicine, tumor microenvironment, nanoparticles, prodrug, targeted nanomedicine, combination, and cancer immunotherapy as the current research hotspots.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Biochemistry & Molecular Biology

The landscape of mRNA nanomedicine

Xiangang Huang et al.

Summary: mRNA is an emerging therapeutic agent with great potential for revolutionizing life science and medical research. Recent progress in mRNA engineering and delivery has addressed the challenges related to stability, immunogenicity, and in vivo delivery. The success of mRNA vaccines against COVID-19 has transformed the field and opened up possibilities for treating other diseases.

NATURE MEDICINE (2022)

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Article Biotechnology & Applied Microbiology

Uncovering the mode of action of engineered T cells in patient cancer organoids

Johanna F. Dekkers et al.

Summary: This study utilizes a system called BEHAV3D to investigate the dynamic interactions between immune cells and patient cancer organoids. By live-tracking a large number of engineered T cells cultured with patient-derived solid-tumor organoids, a cluster of "super engager" T cells with potent serial killing capacity is identified. The study also examines cancer metabolome-sensing engineered T cells (TEGs) and identifies behavior-specific gene signatures in these cells. Additionally, it demonstrates the ability of type I interferon to prime resistant organoids for TEG-mediated killing.

NATURE BIOTECHNOLOGY (2022)

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Editorial Material Chemistry, Multidisciplinary

What Do We Mean When We Say Nanomedicine?

Luis M. Liz-Marzan et al.

ACS NANO (2022)

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Article Nanoscience & Nanotechnology

A Novel Dextran-Based Dual Drug Conjugate Targeted Tumors with High Biodistribution Ratio of Tumors to Normal Tissues

Jiaojiao Liu et al.

Summary: A novel dextran-based dual drug delivery system was developed to enhance drug solubility, improve pharmacokinetic properties, and achieve selective accumulation of drugs in tumor tissues, leading to effective eradication of tumor cells.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Review Biotechnology & Applied Microbiology

In Vitro Cancer Models: A Closer Look at Limitations on Translation

Nina Antunes et al.

Summary: In vitro cancer models are considered as efficient screening platforms for potential therapies and personalized treatments. However, the low success rate of cancer therapeutics calls for critical evaluation of current preclinical platforms to accelerate the development and commercialization of in vitro cancer models.

BIOENGINEERING-BASEL (2022)

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Review Chemistry, Multidisciplinary

Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Jingchao Li et al.

Summary: Immunotherapy harnesses the immune system to eliminate malignant cells, but faces challenges such as limited patient response rates and immune-related adverse events. Electromagnetic nanomaterials can induce immunogenic cell death and are used in combination with cancer immunotherapy for reprogramming the tumor microenvironment.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Pharmacology & Pharmacy

Clinical translation of nanomedicines: Challenges, opportunities, and keys

Mahmoud A. Younis et al.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Chemistry, Physical

Rethinking organoid technology through bioengineering

Elena Garreta et al.

Summary: Significant progress has been made in the differentiation of human pluripotent stem cells and the development of organoids. The convergence of stem cell biology and bioengineering allows for controlled stimuli to be provided to the system. Engineering solutions are emphasized to control the self-organization and functionality of stem cell-derived organoids.

NATURE MATERIALS (2021)

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Article Biochemical Research Methods

Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells

Hiroyuki Koike et al.

Summary: This study introduces a method for continuous patterning of hepatic, biliary and pancreatic structures from human pluripotent stem cells (PSCs) in 3D culture. By fusing anterior and posterior gut spheroids together in one well, the self-patterning of multi-organ (HBP) domains occurs within the boundary region of the two spheroids. Long-term culture of these structures leads to the differentiation of segregated organs with developmentally relevant features.

NATURE PROTOCOLS (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Oncology

Patient-Derived Organoids for Precision Cancer Immunotherapy

Mikaela Gronholm et al.

Summary: Cancer immunotherapy has transformed tumor treatment, but there is a lack of efficient testing platforms for pretreatment evaluation of therapies and understanding the tumor microenvironment. Patient-derived tumor organoid cultures and complex immune-organoid cultures offer potential for preclinical testing platforms in precision cancer immunotherapy.

CANCER RESEARCH (2021)

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Article Multidisciplinary Sciences

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

Teresa G. Krieger et al.

Summary: Using single-cell transcriptome analysis, researchers identified a hierarchy of distinct cell states within pancreatic ductal adenocarcinoma (PDAC), including both 'classical' and 'basal-like' cells. They also found that different tumor cell states are connected by a differentiation hierarchy within organoids.

NATURE COMMUNICATIONS (2021)

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Article Engineering, Biomedical

An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity

Zhuolong Zhou et al.

Summary: High-throughput screening in breast tumour organoids can identify epigenetic inhibitors that promote antigen presentation and enhance T-cell-mediated cytotoxicity.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Nanoscience & Nanotechnology

Cancer nanotechnology: current status and perspectives

Jessica A. Kemp et al.

Summary: Modern medicine has been fighting against cancer for nearly a century with no clear end in sight. The need to increase specificity and decrease systemic toxicities in cancer treatments remains. Nanotechnology shows potential in revolutionizing diagnostic tools and improving patient care in cancer treatment.

NANO CONVERGENCE (2021)

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Article Nanoscience & Nanotechnology

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer

Ran Li et al.

Summary: The study demonstrates that the accumulation of nanoparticle albumin bound paclitaxel in tumors is influenced by signaling molecules related to nutrient uptake and processing, which can be reprogrammed to enhance the drug's efficacy.

NATURE NANOTECHNOLOGY (2021)

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Review Immunology

Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

Thai Thanh Hoang Thi et al.

Summary: This review highlights the importance of lipid-based nanoparticles in the development of COVID-19 vaccines and other nanomedicines, focusing on innovations that have obtained regulatory approval or are in clinical trials. It also discusses the physicochemical properties required for specific applications, emphasizes the differences in requirements for delivering different cargos, and introduces current challenges that need further development.

VACCINES (2021)

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Review Pharmacology & Pharmacy

Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening

Flavia Castro et al.

Summary: Colorectal cancer is a heterogeneous and molecularly complex disease that requires novel therapeutic approaches. Traditional 2D models and animal models have limitations, while multicellular 3D systems are emerging as a promising tool in cancer research.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses

Ahmad Sohrabi Kashani et al.

Summary: Understanding the unknown mechanobiological responses to nano-bio-interaction is crucial in designing safe and effective nanomedicines. Studies have shown that the mechanobiological properties of cells, such as elasticity and adhesion, play key roles in cellular functions and cancer progression. Monitoring the mechanobiological responses of treated cells can help evaluate the efficiency of nanomedicines and develop applications to modulate cell mechanics for controlling cancer progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Physical

Obstacles and opportunities in a forward vision for cancer nanomedicine

Irene de Lazaro et al.

Summary: This text discusses the biological barriers that have hindered the clinical translation of cancer nanomedicines, and elaborates on new directions for the field that capitalize on a deeper understanding of the nano-bio interface.

NATURE MATERIALS (2021)

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Review Chemistry, Medicinal

Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine

Fikadu Ejeta

Summary: Microfluidics offers a promising approach to address the challenges of nanomedicine drug delivery systems, particularly in terms of controlled and reproducible production of nanoparticles. However, digital microfluidics with droplets and liquid marbles may provide a solution to issues such as cumbersome external structures and large pattern volumes, advancing the practical use of this technology.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

Cancer models in preclinical research: A chronicle review of advancement in effective cancer research

Humna Sajjad et al.

Summary: Cancer models are essential tools in cancer research, providing insights into cancer development and progression, as well as guiding treatment strategies. Despite their limitations, these models are crucial for developing new therapies and drugs for cancer, bridging the gap between basic research and clinical application for a brighter future in cancer treatment.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2021)

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Review Chemistry, Multidisciplinary

Nano-Bio Interactions in Cancer: From Therapeutics Delivery to Early Detection

Yuan Liu et al.

Summary: Understanding the interactions between nanomaterials and biological systems is crucial for improving the efficacy of nanomedicine and advancing disease diagnosis. The nanoparticle-protein corona has a decisive effect on the in vivo fate of nanomedicine and can be used to enrich low-abundance proteins for biomarker discovery.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Review Oncology

Emerging drug profile: CPX-351 (vyxeos) in AML

Mansour Alfayez et al.

LEUKEMIA & LYMPHOMA (2020)

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Article Cell & Tissue Engineering

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Ye Yao et al.

CELL STEM CELL (2020)

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Review Chemistry, Medicinal

Albumin nanoscience: homing nanotechnology enabling targeted drug delivery and therapy

Shrawani Lamichhane et al.

ARCHIVES OF PHARMACAL RESEARCH (2020)

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Review Oncology

Applications of patient-derived tumor xenograft models and tumor organoids

Go J. Yoshida

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

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Article Nursing

Co-administration of multiple intravenous medicines: Intensive care nurses' views and perspectives

Mosopefoluwa S. Oduyale et al.

NURSING IN CRITICAL CARE (2020)

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Article Oncology

Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity

Jarle Bruun et al.

CLINICAL CANCER RESEARCH (2020)

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Article Instruments & Instrumentation

Challenges in nanomedicine clinical translation

Josbert M. Metselaar et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Review Cell Biology

Human organoids: model systems for human biology and medicine

Jihoon Kim et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Aleksandra Zielinska et al.

MOLECULES (2020)

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Article Oncology

Efficacy and Safety of nab-Paclitaxel vs Paclitaxel on Survival in Patients With Platinum-Refractory Metastatic Urothelial Cancer The Canadian Cancer Trials Group BL.12 Randomized Clinical Trial

Srikala S. Sridhar et al.

JAMA ONCOLOGY (2020)

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Review Chemistry, Multidisciplinary

Progress, challenges, and future of nanomedicine

Chenyang Zhang et al.

NANO TODAY (2020)

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Article Chemistry, Multidisciplinary

Investigating the EPR effect of nanomedicines in human renal tumors via ex vivo perfusion strategy

Yuxun Ding et al.

NANO TODAY (2020)

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Article Medicine, Research & Experimental

High-resolution 3D visualization of nanomedicine distribution in tumors

Jennifer I. Moss et al.

THERANOSTICS (2020)

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Review Pharmacology & Pharmacy

Clinical Translation of Nanomedicine and Biomaterials for Cancer Immunotherapy: Progress and Perspectives

Yang Shi

ADVANCED THERAPEUTICS (2020)

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Article Multidisciplinary Sciences

Separating host and microbiome contributions to drug pharmacokinetics and toxicity

Michael Zimmermann et al.

SCIENCE (2019)

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Article Biochemistry & Molecular Biology

3D model for CAR-mediated cytotoxicity using patient-derived colorectal cancer organoids

Theresa E. Schnalzger et al.

EMBO JOURNAL (2019)

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Review Chemistry, Multidisciplinary

The Nano-Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions

Yaling Wang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Editorial Material Chemistry, Multidisciplinary

The beginning of the end of the nanomedicine hype

Kinam Park

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Multidisciplinary Sciences

Organoids by design

Takanori Takebe et al.

SCIENCE (2019)

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Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

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Article Oncology

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

Ela Elyada et al.

CANCER DISCOVERY (2019)

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Review Chemistry, Multidisciplinary

Survey of Clinical Translation of Cancer Nanomedicines-Lessons Learned from Successes and Failures

Hongliang He et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

Yochai Wolf et al.

CELL (2019)

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Article Chemistry, Multidisciplinary

Translation of nanomedicines from lab to industrial scale synthesis: The case of squalene-adenosine nanoparticles

Flavio Dormont et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates: Towards Conquering Desmoplasia?

Girgis Obaid et al.

NANO LETTERS (2019)

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Article Nanoscience & Nanotechnology

Smart cancer nanomedicine

Roy van der Meel et al.

NATURE NANOTECHNOLOGY (2019)

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Article Multidisciplinary Sciences

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

Minsuh Kim et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma

Eva A. Ebbing et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Multidisciplinary Sciences

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Else Driehuis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Biotechnology & Applied Microbiology

Nanoparticles in the clinic: An update

Aaron C. Anselmo et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2019)

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Review Engineering, Biomedical

Nanostructured carriers as innovative tools for cancer diagnosis and therapy

Chiara Martinelli et al.

APL BIOENGINEERING (2019)

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Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Oncology

Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment

Hiroyoshi Y. Tanaka et al.

CANCER SCIENCE (2018)

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Article Biochemistry & Molecular Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs et al.

CELL (2018)

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Review Oncology

Improving combination cancer therapy: the CombiPlex((R)) development platform

Anthony W. Tolcher et al.

FUTURE ONCOLOGY (2018)

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Article Multidisciplinary Sciences

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Georgios Vlachogiannis et al.

SCIENCE (2018)

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Review Biotechnology & Applied Microbiology

Personalized Cancer Medicine: An Organoid Approach

Hamidreza Aboulkheyr Es et al.

TRENDS IN BIOTECHNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Organoid Modeling of the Tumor Immune Microenvironment

James T. Neal et al.

CELL (2018)

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Review Pharmacology & Pharmacy

Tumor Microenvironment Targeted Nanotherapy

Clara Fernandes et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Biochemistry & Molecular Biology

The significance of intertumor and intratumor heterogeneity in liver cancer

Jinping Liu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

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Review Nanoscience & Nanotechnology

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Fakhar Ud Din et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Immunology

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Daniel Ohlund et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

Laura Broutier et al.

NATURE MEDICINE (2017)

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Article Multidisciplinary Sciences

Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

Akira Yokoi et al.

NATURE COMMUNICATIONS (2017)

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Article Oncology

Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

Niklas K. Finnberg et al.

ONCOTARGET (2017)

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Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

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Review Oncology

Cancer nanomedicine: a review of recent success in drug delivery

Stephanie Tran et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2017)

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Review Pharmacology & Pharmacy

Drug Combination in Clinical Cancer Treatments

Da-Yong Lu et al.

REVIEWS ON RECENT CLINICAL TRIALS (2017)

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Article Chemistry, Multidisciplinary

Diverse Applications of Nanomedicine

Beatriz Pelaz et al.

ACS NANO (2017)

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Review Pharmacology & Pharmacy

Challenges and strategies in anti-cancer nanomedicine development: An industry perspective

Jennifer I. Hare et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

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Review Biochemistry & Molecular Biology

Modeling Development and Disease with Organoids

Hans Clevers

CELL (2016)

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Article Cell & Tissue Engineering

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Masayuki Fujii et al.

CELL STEM CELL (2016)

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Article Gastroenterology & Hepatology

Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes

Kengo Nozaki et al.

JOURNAL OF GASTROENTEROLOGY (2016)

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Review Biotechnology & Applied Microbiology

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

Nazanin Hoshyar et al.

NANOMEDICINE (2016)

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Review Biochemistry & Molecular Biology

Regulatory aspects on nanomedicines

Vanessa Sainz et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

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Article Oncology

Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration

Nianhang Chen et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2015)

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Article Biochemistry & Molecular Biology

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj et al.

CELL (2015)

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Review Chemistry, Multidisciplinary

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

Andreas Wicki et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

Ling Huang et al.

NATURE MEDICINE (2015)

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Article Biochemistry & Molecular Biology

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Hui Gao et al.

NATURE MEDICINE (2015)

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Article Cell Biology

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

Miles A. Miller et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Article Chemistry, Medicinal

Albumin-bound paclitaxel in solid tumors: clinical development and future directions

Madappa Kundranda et al.

Drug Design Development and Therapy (2015)

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Review Pharmacology & Pharmacy

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

Nicolas Bertrand et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

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Review Chemistry, Multidisciplinary

EPR: Evidence and fallacy

Joseph W. Nichols et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

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