期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 72, 期 5, 页码 603-615出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glw152
关键词
Sirtuins; Adipose inflammation; Voluntary activity; AMPK
资金
- Israel Science Foundation [621/13]
- I-Core Foundation [41/11]
- Israeli Ministry of Health [3.9194]
- TEVA NNE Program [PO 1237680]
- ESFD
- D-Cure
- Israel Cancer Association [2016-0103]
- ERC: European Research Council [242765]
- European Foundation for the Study of Diabetes [MSD 2014_1] Funding Source: researchfish
The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases. It is therefore crucial to identify key factors that control elderly healthspan. Similar to dietary restriction, mice overexpressing the NAD+ dependent protein deacylase SIRT6 (MOSES) live longer and have reduced IGF-1 levels. However, it is as yet unknown whether SIRT6 also affects various healthspan parameters. Here, a range of age related phenotypes was evaluated in MOSES mice. In comparison to their wild-type (WT) littermates, old MOSES mice showed amelioration of a variety of age-related disorders, including: improved glucose tolerance, younger hormonal profile, reduced age-related adipose inflammation and increased physical activity. The increased activity was accompanied with increased muscle AMP-activated protein kinase (AMPK) activity. Altogether, these results indicate that overexpression of SIRT6 in mice retards important aspects of the aging process and suggest SIRT6 to be a potential therapeutic target for the treatment of a set of age-related disorders.
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