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Article
Multidisciplinary Sciences
Egon A. Ozer et al.
Summary: SARS-CoV-2 genomic surveillance is crucial for understanding the viral population dynamics and identifying important variants. However, many regions, including Nigeria, have been under-sampled, leading to limited knowledge of circulating strains. This study sequenced 378 isolates from Nigeria and identified two locally important strains that are globally uncommon. The findings highlight the need for improved genomic surveillance worldwide.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Daniel J. Grint et al.
Summary: The study found that the SARS-CoV-2 alpha variant is more transmissible and associated with increased rates of hospitalization and mortality compared to the wild-type virus in England between November 16, 2020 and January 11, 2021.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Tamara Kaleta et al.
Summary: In spring 2021, an increasing number of infections caused by the rarely described SARS-CoV-2 variant A.27 were observed in southwest Germany. This variant, which shares some spike gene mutations with variants of concern but lacks the dominant D614G mutation, has spread globally and shows escape from convalescent and vaccine-induced immunity. Continued global monitoring is necessary due to the independent evolution of new escape mutations.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Collins M. Morang'a et al.
Summary: This study tracks the molecular evolution and spatio-temporal dynamics of SARS-CoV-2 variants in Ghana, finding that the virus has rapidly evolved and different variants have dominated transmission at different times.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Yacouba Sawadogo et al.
Summary: This study provides a genomic epidemiology of SARS-CoV-2 in Burkina Faso, highlighting the role of cross-border human mobility in the spread of the virus. The findings emphasize the importance of implementing preventive policies and regional cross-border collaborations to prevent new epidemic waves.
Letter
Immunology
Solene Grayo et al.
Summary: This article provides an overview of the circulation of severe acute respiratory syndrome coronavirus 2 over 1.5 years in Guinea, indicating that different virus clades and variants of interest and concern were gradually introduced through travelers via Conakry and subsequently spread throughout the country. Sequencing plays a crucial role in tracking virus evolution and establishing effective control strategies.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Houriiyah Tegally et al.
Summary: The article describes a newly emerged lineage of SARS-CoV-2, 501Y.V2, characterized by eight mutations in the spike protein, which may result in increased transmissibility or immune escape. This lineage originated in South Africa and quickly became dominant in Eastern Cape, Western Cape, and KwaZuluNatal provinces within weeks.
Article
Biochemistry & Molecular Biology
Houriiyah Tegally et al.
Summary: The study identified 16 new lineages of SARS-CoV-2 in South Africa between March and August 2020, with unique mutations not found elsewhere. Three lineages (B.1.1.54, B.1.1.56, and C.1) dominated during the country's first wave, accounting for approximately 42% of all infections. The C.1 lineage, with 16 nucleotide mutations including the D614G spike protein change, became the most geographically widespread by August 2020. Genomic surveillance played a crucial role in identifying the 501Y.V2 variant in South Africa in December 2020.
Article
Multidisciplinary Sciences
Eduan Wilkinson et al.
Summary: The progression of the SARS-CoV-2 pandemic in Africa has shown heterogeneous patterns, with many countries experiencing epidemics initiated mainly by imports from Europe. The implementation of early travel restrictions helped reduce this trend. However, ongoing transmission and increasing mobility within Africa have led to the emergence and spread of various concerning variants. This highlights the importance of not neglecting Africa in the global pandemic response to prevent it from becoming a source of new variants.
Article
Multidisciplinary Sciences
Wasco Wruck et al.
Summary: The study revealed different patterns of SARS-CoV-2 variants within West African countries, indicating their global transmission via air traffic from Europe, with limited transmission between the West African countries.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Grit Schubert et al.
Summary: ANDEMIA aims to expand our understanding of ARI, GI and AFDUC aetiologies in sub-Saharan Africa using a comprehensive laboratory diagnostics strategy, fostering early detection of emerging threats and continued monitoring of important common pathogens. The network collaboration will be strengthened and site diagnostic capacities will be reinforced to improve quality management and patient care.
BMC INFECTIOUS DISEASES
(2021)
Review
Genetics & Heredity
Kaiming Tao et al.
Summary: The emergence of multiple SARS-CoV-2 variants has significant impacts on the epidemiological and clinical aspects of the COVID-19 pandemic, including increased virus transmission rates, heightened risk of reinfection, and reduced effectiveness of neutralizing antibodies and vaccines. These variants have introduced new challenges to COVID-19 research, necessitating additional avenues of laboratory, epidemiological, and clinical studies.
NATURE REVIEWS GENETICS
(2021)
Article
Microbiology
Daniel Lule Bugembe et al.
Summary: The SARS-CoV-2 variant A.23.1 emerged and became predominant in Uganda, showing amino acid changes in both the spike protein and non-spike proteins similar to other known variants of concern. While the clinical impact of the A.23.1 variant is still unclear and it has not been designated as a variant of concern, careful monitoring and assessment of its impact on COVID-19 vaccine efficacy are advisable.
NATURE MICROBIOLOGY
(2021)
Article
Immunology
Anna-Lena Sander et al.
Summary: Intense transmission of SARS-CoV-2 in Africa may lead to variant emergence, as seen in the 10 lineages identified in Benin that were more effectively neutralized by antibodies from vaccinees. This highlights the need for accelerated vaccination efforts in Africa.
EMERGING INFECTIOUS DISEASES
(2021)
Editorial Material
Medicine, General & Internal
Chen Wang et al.
Article
Biochemistry & Molecular Biology
Bui Quang Minh et al.
MOLECULAR BIOLOGY AND EVOLUTION
(2020)
Article
Microbiology
Andrew Rambaut et al.
NATURE MICROBIOLOGY
(2020)
Article
Biochemical Research Methods
James Hadfield et al.
Article
Virology
Pavel Sagulenko et al.
Article
Biochemical Research Methods
Subha Kalyaanamoorthy et al.
Article
Multidisciplinary Sciences
Stefan Elbe et al.
Article
Biochemistry & Molecular Biology
Kazutaka Katoh et al.
MOLECULAR BIOLOGY AND EVOLUTION
(2013)
