☆ 4.5 Review

Revolutionizing viral disease vaccination: the promising clinical advancements of non-replicating mRNA vaccines

VIROLOGY JOURNAL (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Editorial Material Multidisciplinary Sciences

First clinical study of germline-targeting strategy: One step closer to a successful bnAb-based HIV vaccine

Caijun Sun et al.

INNOVATION (2023)

添加到收藏夹

Article Oncology

Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer

Nadja Salomon et al.

Summary: The study demonstrates that the E7 RNA-LPX vaccine, when combined with standard-of-care local radiotherapy (LRT), synergizes to produce potent therapeutic effects in HPV16(+) mouse tumors. This combination enhances the anti-tumor activity, making cold tumors immunologically hot and sensitizing tumor cells to antigen-specific T cell-mediated killing. These results pave the way for a new translational therapy for HPV16(+) cancer patients.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

添加到收藏夹

Review Biochemical Research Methods

Principles for designing an optimal mRNA lipid nanoparticle vaccine

Edo Kon et al.

Summary: mRNA lipid nanoparticles (LNPs) have gained significant attention as therapeutic platforms due to the success of the SARS-CoV-2 mRNA LNP vaccines. The modularity and rapid manufacturing capabilities are the advantages of mRNA-LNP vaccines. When designing optimal mRNA-LNPs, choices regarding efficacy, stability, and toxicity need to be made.

CURRENT OPINION IN BIOTECHNOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Lyophilization provides long-term stability for a lipid nanoparticle-formulated , nucleoside-modified mRNA vaccine

Hiromi Muramatsu et al.

Summary: Research demonstrates that nucleoside-modified mRNA-LNP vaccines can be lyophilized and maintain their physicochemical properties after storage at room temperature for 12 weeks or at 4℃ for at least 24 weeks. Comparative studies also show that lyophilized mRNA-LNP vaccines maintain high expression and immunogenicity even after storage.

MOLECULAR THERAPY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

Makda S. Gebre et al.

Summary: In non-human primates, the second-generation mRNA vaccine CV2CoV was found to induce higher levels of immune responses and provide stronger protection against SARS-CoV-2 variants compared to CVnCoV. The optimization of non-coding regions greatly improved the immunogenicity and protective efficacy of the non-modified mRNA vaccine in non-human primates.

NATURE (2022)

添加到收藏夹

Letter Medicine, General & Internal

Effects of a Prolonged Booster Interval on Neutralization of Omicron Variant

Xin Zhao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

添加到收藏夹

Review Medical Laboratory Technology

An mRNA vaccine to prevent genital herpes

Sita Awasthi et al.

Summary: The rapid development of two nucleoside-modified mRNA vaccines has revolutionized the field of COVID-19 vaccines with their safety and high effectiveness. The mRNA technology offers advantages such as accelerated immunogen discovery, robust immune response induction, and rapid manufacturing scale-up. Developing a genital herpes vaccine has been a longstanding public health priority, and the advent of mRNA technology holds promise in changing the narrative. The development of nucleoside-modified mRNA-lipid nanoparticle vaccines for genital herpes shows great potential in inducing higher levels of neutralizing antibodies and more durable immune responses compared to protein-adjuvanted vaccines.

TRANSLATIONAL RESEARCH (2022)

添加到收藏夹

Review Immunology

SARS-CoV-2 Variants, Vaccines, and Host Immunity

Priyal Mistry et al.

Summary: The emergence of SARS-CoV-2 and the subsequent COVID-19 pandemic has led to the development of vaccines and investigation into the immune response to the virus. Variants of the virus have presented challenges to vaccine effectiveness. It is important to understand the immune memory response and continue to develop new antibody treatments and future vaccine approaches.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Circular RNA vaccines against SARS-CoV-2 and emerging variants

Liang Qu et al.

Summary: This study reports a circular RNA vaccine that provides potent protection against SARS-CoV-2 by eliciting neutralizing antibodies and T cell responses. The circRNA vaccine exhibits higher and more durable antigen production compared to mRNA vaccines and shows efficacy against the current variants of concern.

CELL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Humoral and cellular immune memory to four COVID-19 vaccines

Zeli Zhang et al.

Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.

CELL (2022)

添加到收藏夹

Article Cell Biology

Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters

Yong-Qiang Deng et al.

Summary: The study presents a rapid and cost-effective platform for in vivo delivery of SARS-CoV-2 neutralizing antibodies. A single administration of the mRNA antibodies provided long-term protection against SARS-CoV-2 and prevented its transmission in animal models.

CELL RESEARCH (2022)

添加到收藏夹

Article Food Science & Technology

Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Stephanie Seneff et al.

Summary: This study provides evidence that mRNA vaccines may have adverse effects on human health, including impairment of interferon signaling system and potential links to other diseases. The study calls for a comprehensive risk/benefit assessment of mRNA vaccines.

FOOD AND CHEMICAL TOXICOLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis

Tobias Boettler et al.

Summary: This case report highlights the occurrence of autoimmune hepatitis episodes following COVID-19 vaccination in a patient with distinctive T cell-dominant immune-mediated hepatitis. Liver tissue analysis revealed an immune infiltrate with activated cytotoxic CD8 T cells predominantly distributed, indicating a unique pathomechanism associated with vaccination-induced antigens.

JOURNAL OF HEPATOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency

Sun Chang Kim et al.

Summary: Modifying mRNA structural elements, such as the 5' cap, 5'-and 3'-untranslated regions (UTRs), the coding region, and polyadenylation tail, helps reduce excessive mRNA immunogenicity and improve intracellular stability and translational efficiency. Further research on mRNA structural elements and their optimization is needed to advance the engineering of mRNA vaccines.

MOLECULAR & CELLULAR TOXICOLOGY (2022)

添加到收藏夹

Article Pediatrics

Household Transmission and Clinical Features of SARS-CoV-2 Infections

Huong Q. McLean et al.

Summary: Both children and adults can transmit and are susceptible to SARS-CoV-2 infection. The age of the primary case does not affect the SIR. Further research is needed to understand the age-related differences in the probability of transmission from primary cases.

PEDIATRICS (2022)

添加到收藏夹

Article Immunology

Safety and Immunogenicity of an mRNA-Based Human Metapneumovirus and Parainfluenza Virus Type 3 Combined Vaccine in Healthy Adults

Allison August et al.

Summary: This study assessed the safety and immunogenicity of an investigational mRNA-based hMPV and PIV3 combination vaccine in healthy adults aged 18-49 years. The vaccine was found to have an acceptable safety profile and increased neutralization titers against hMPV and PIV3.

OPEN FORUM INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Medicine, General & Internal

Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical Trial

Dean Follmann et al.

Summary: This study evaluated the seropositivity of anti-nucleocapsid antibody (anti-N Ab) in mRNA-1273 vaccinees with breakthrough SARS-CoV-2 infection. The results showed a lower seroconversion rate in vaccinees, indicating the importance of considering vaccination status when interpreting seroprevalence and seropositivity data based solely on anti-N Ab testing.

ANNALS OF INTERNAL MEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection

Zhifen Cui et al.

Summary: This study utilized a chemically engineered nanosystem encapsulating CRISPR-Cas13d to decrease lung Ctsl expression in mice, extending survival of mice infected with SARS-CoV-2, reducing lung virus burden, and alleviating the severity of pathological changes.

NATURE CHEMICAL BIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Psychrophilic phage VSW-3 RNA polymerase reduces both terminal and full-length dsRNA byproducts in in vitro transcription

Heng Xia et al.

Summary: The novel single-subunit RNA polymerase (RNAP) encoded by the psychrophilic phage VSW-3 enables in vitro RNA synthesis at low temperatures and produces RNA with high purity and without double-stranded RNA byproducts.

RNA BIOLOGY (2022)

添加到收藏夹

Letter Cell Biology

mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2

Yuxuan Han et al.

CELL RESEARCH (2022)

添加到收藏夹

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

Lorena Sanchez-Felipe et al.

Summary: The candidate vaccine YF-S0, utilizing the YF17D vaccine as a vector to express noncleavable prefusion form of the SARS-CoV-2 spike antigen, showed excellent safety, immunogenicity, and efficacy in animal models. It induced high levels of neutralizing antibodies, provided protective immunity against SARS-CoV-2, and prevented infection in hamsters and macaques. A single dose was able to confer protection from lung disease in most vaccinated hamsters within 10 days, highlighting the potential of YF-S0 as a potent SARS-CoV-2 vaccine candidate.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

Christina Krienke et al.

Summary: The study demonstrates the potential use of modified m1 Psi mRNA in the treatment of multiple sclerosis, showing its ability to suppress the disease, promote the development of T-reg cell populations, and enhance bystander immunosuppression.

SCIENCE (2021)

添加到收藏夹

Article Immunology

Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial

Cassandra Aldrich et al.

Summary: Immune responses to rabies virus glycoprotein (RABV-G)-mRNA vaccine were dependent on the route of administration, necessitating specialized devices. The results showed that the 1 or 2 microgram doses were well tolerated and elicited rabies neutralizing antibody responses that met WHO criteria in all recipients.

VACCINE (2021)

添加到收藏夹

Article Infectious Diseases

Herpes zoster after COVID vaccination

C. S. van Dam et al.

Summary: COVID-19 can present with skin manifestations, including reactivation of herpes zoster. Vaccination may lead to transient lymphocytopenia, similar to that seen in COVID-19 disease. Further evaluation is needed to determine the relationship between COVID-19, COVID vaccines, and herpes zoster.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Allergy

mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach

Aleena Banerji et al.

Summary: The FDA has authorized emergency use of Pfizer-BioNTech and Moderna COVID-19 vaccines, but individuals with severe allergic reactions are advised against receiving them. The CDC recommends observing those with a history of immediate allergies or anaphylaxis for 30 minutes post-vaccination, while all others should be observed for 15 minutes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Self-assembled mRNA vaccines

Jeonghwan Kim et al.

Summary: mRNA vaccines, emerging as front-runners in the COVID-19 vaccine race, utilize advancements in RNA technology, vaccinology, and nanotechnology to design self-assembled nanoparticles for vaccine delivery, showing tremendous promise and readiness for clinical use.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies

Kajal Rawat et al.

Summary: COVID-19, caused by a new strain of betacoronavirus named as SARS-CoV-2, poses a huge burden on public health and global economies due to its high transmission rate. Developing vaccines is essential for preventing the spread of the virus and reducing mortality.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus

Allison August et al.

Summary: The study evaluated the safety and pharmacology of mRNA-1944 as a treatment for Chikungunya virus (CHIKV) infection, showing good safety and tolerability in healthy participants. Additionally, mRNA-1944 demonstrated the ability to produce effective neutralizing antibodies, suggesting potential for treating CHIKV infection.

NATURE MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

mRNA vaccine: a potential therapeutic strategy

Yang Wang et al.

Summary: mRNA vaccines have great potential in fighting cancer and viral diseases, with advancements in sequence optimization and delivery strategies to enhance efficacy and stability, and importance in increasing antigen reactivity.

MOLECULAR CANCER (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

mRNA in cancer immunotherapy: beyond a source of antigen

Lien Van Hoecke et al.

Summary: mRNA therapeutics have become a focus in molecular medicine research, particularly in the field of immuno-oncology. The versatility and advantages of mRNA go beyond cancer vaccine development, with potential for endless therapeutic applications through smart design and pharmaceutical formulations. Novel immunotherapeutic strategies are now exploring the use of mRNA beyond tumor antigens as a source, showing promise for clinical applications.

MOLECULAR CANCER (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy

Yue Yin et al.

Summary: The research team developed a transformable hydrogel that can generate nanovaccines for up to 30 days after injection, showing promising potential for effective cancer immunotherapy.

NANO LETTERS (2021)

添加到收藏夹

Review Immunology

Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

Kelvin Kai-Wang To et al.

Summary: The lack of modern medical management and vaccines could lead to the COVID-19 pandemic reaching the levels of past deadly outbreaks like the 1894 plague and 1918-A(H1N1) influenza pandemic. The presence of multiple coronaviruses with pandemic potential in animals, coupled with environmental factors like the mixing and selling of wild mammals with poor hygiene practices in urban markets, pose a significant threat to global health. The emergence of new viruses and the challenges of mass testing, contact tracing, treatment, and potential development of vaccine-resistant virus variants highlight the importance of global preparedness in combating infectious diseases.

EMERGING MICROBES & INFECTIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A randomized study to evaluate safety and immunogenicity of the BNT162b2 COVID-19 vaccine in healthy Japanese adults

Miwa Haranaka et al.

Summary: The interim analysis of the ongoing study of the BNT162b2 vaccine in healthy Japanese adults showed that it has an acceptable safety profile and induces a robust immune response, regardless of age. The participants mainly experienced mild to moderate local reactions and no serious adverse events, with good antibody induction one month after the second dose.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Immunology

An Update on Self-Amplifying mRNA Vaccine Development

Anna K. Blakney et al.

Summary: This review explores the four major pillars required for design and development of an saRNA vaccine, discussing antigen design, vector design, non-viral delivery systems, and manufacturing. It reports on major innovations, preclinical and clinical data from the last five years, and provides insights into future prospects.

VACCINES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA

Sergio Linares-Fernandez et al.

Summary: Researchers developed a new mRNA structure and optimized the purification process to identify the most suitable sequences and transfection efficiency for mRNA vaccines. This technology helps to reduce the components needed for vaccines and enhance vaccine efficacy.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety

Irena Vlatkovic

Summary: LNP-mRNA vaccines, with their advantages of fast engineering and efficient manufacturing, have shown potential in combating SARS-CoV-2 virus. However, in protein replacement therapy, it is crucial to avoid immune activation.

BIOMEDICINES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

An overview of rational design of mRNA-based therapeutics and vaccines

Kenneth K. W. To et al.

Summary: mRNA-based therapeutics and vaccines have become a disruptive new drug class for various applications. Extensive research efforts have been made to optimize mRNA constructs and preparation procedures to overcome obstacles hindering their clinical applications. Further advancements in mRNA design and delivery technologies are needed to broaden the scope and usefulness of this new class of drugs.

EXPERT OPINION ON DRUG DISCOVERY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

High-salt transcription of DNA cotethered with T7 RNA polymerase to beads generates increased yields of highly pure RNA

Elvan Cavac et al.

Summary: High yields of encoded RNA can be generated with reduced double-stranded impurities using a novel in vitro transcription method introduced in this study, which eliminates the need for further purification and has the potential to enable therapies and technologies currently hindered by impurities.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

添加到收藏夹

Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

S. J. Thomas et al.

Summary: BNT162b2 vaccine remains highly effective and safe over the course of 6 months post-vaccination, with efficacy rates ranging from 86% to 100% across different demographics and risk factors for Covid-19. The vaccine also shows a high efficacy against severe disease, with particularly promising results observed in South Africa against the B.1.351 variant.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Infectious Diseases

Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Peter G Kremsner et al.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A single mutation attenuates both the transcription termination and RNA-dependent RNA polymerase activity of T7 RNA polymerase

Hui Wu et al.

Summary: The mutation S43Y in T7 RNAP significantly decreases termination efficiency and almost eliminates RNA-dependent activity, while maintaining DNA-dependent activity. The S43Y mutation increases transcription efficiency and weakens RNA binding, resulting in RNA with higher terminal homogeneity in run-off RNA synthesis.

RNA BIOLOGY (2021)

添加到收藏夹

Article Cell Biology

Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

Christian Hotz et al.

Summary: Local administration of mRNA encoding cytokines has shown effective antitumor activity by inducing various immune cell responses, including systemic antigen-specific T cell expansion, increased granzyme B+ T cell infiltration, and formation of immune memory. Combining these mRNAs with immunomodulatory antibodies enhances antitumor responses in both injected and uninjected tumors, improving survival and tumor regression.

SCIENCE TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in models

Sita Awasthi et al.

Summary: Nucleoside-modified mRNA vaccines show more durable protection in animal models compared to protein vaccines, with higher neutralizing antibody titers and robust B cell immune memory. The correlation between high neutralizing titers and B cell immune memory likely explains the more lasting protection provided by the mRNA vaccine.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity

Ren Yang et al.

Summary: SW0123 is a highly efficacious mRNA vaccine candidate with strong immunogenicity, inducing T cell and antibody responses, capable of neutralizing multiple variants, and providing effective protection in animal challenge experiments.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Is a Universal Influenza Virus Vaccine Possible?

Raffael Nachbagauer et al.

ANNUAL REVIEW OF MEDICINE, VOL 71, 2020 (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

Sergio Linares-Fernandez et al.

TRENDS IN MOLECULAR MEDICINE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

mRNA modification orchestrates cancer stem cell fate decisions

Weicheng Liang et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

N1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells

Callum J. C. Parr et al.

NUCLEIC ACIDS RESEARCH (2020)

添加到收藏夹

Review Immunology

The promise of mRNA vaccines: a biotech and industrial perspective

Nicholas A. C. Jackson et al.

NPJ VACCINES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Development of an inactivated vaccine candidate for SARS-CoV-2

Qiang Gao et al.

SCIENCE (2020)

添加到收藏夹

Article Oncology

Once, Twice, Three Times a Finding: Reproducibility of Dendritic Cell Vaccine Trials Targeting Cytomegalovirus in Glioblastoma

Kristen A. Batich et al.

CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Thermostable mRNA Vaccine against COVID-19

Na-Na Zhang et al.

CELL (2020)

添加到收藏夹

Article Medicine, Research & Experimental

mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice

Lien Van Hoecke et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in Mice

Mengling Zhang et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

添加到收藏夹

Article Medicine, General & Internal

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Kizzmekia S. Corbett et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection

Shuqin Xu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Medicine, General & Internal

Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

Cheryl Keech et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Single-pass transcription by T7 RNA polymerase

Luiz F. M. Passalacqua et al.

RNA (2020)

添加到收藏夹

Review Immunology

The Immune Response and Immunopathology of COVID-19

Esmaeil Mortaz et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection

Jesse H. Erasmus et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

添加到收藏夹

Review Medicine, Research & Experimental

How mRNA therapeutics are entering the monoclonal antibody field

Lien Van Hoecke et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

添加到收藏夹

Article Immunology

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

Robert A Feldman et al.

VACCINE (2019)

添加到收藏夹

Article Medicine, Research & Experimental

A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA

Markus Baiersdoerfer et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

添加到收藏夹

Article Genetics & Heredity

Improved translation efficiency of therapeutic mRNA

Farzaneh Zarghampoor et al.

GENE (2019)

添加到收藏夹

Article Medicine, Research & Experimental

iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy

Wesley de Jong et al.

TRIALS (2019)

添加到收藏夹

Article Immunology

A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice

Claude Roth et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

Nurgun Kose et al.

SCIENCE IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

HIGH-RISK HPV testing as the primary screening method in an organized regional screening program for cervical cancer: the value of HPV16 and HPV18 genotyping?

Saara Kares et al.

APMIS (2019)

添加到收藏夹

Article Immunology

Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes

Sita Awasthi et al.

SCIENCE IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Advances in mRNA Vaccines for Infectious Diseases

Cuiling Zhang et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease

Michelle Meyer et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

The highly efficient T7 RNA polymerase: A wonder macromolecule in biological realm

Subhomoi Borkotoky et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

添加到收藏夹

Editorial Material Medicine, General & Internal

Monoclonal Antibodies for Emerging Infectious Diseases - Borrowing from History

Hilary D. Marston et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Immunology

Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity

Shinu John et al.

VACCINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Pooja Munnilal Tiwari et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Virology

Epstein-Barr Virus Strains and Variations: Geographic or Disease-Specific Variants?

Marco Neves et al.

JOURNAL OF MEDICAL VIROLOGY (2017)

添加到收藏夹

Article Medicine, General & Internal

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

Martin Alberer et al.

LANCET (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

Kapil Bahl et al.

MOLECULAR THERAPY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Short poly(A) tails are a conserved feature of highly expressed genes

Sarah Azoubel Lima et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Type I lnterferons Modulate CD8+ T Cell Immunity to mRNA Vaccines

Ans De Beuckelaer et al.

TRENDS IN MOLECULAR MEDICINE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

Norbert Pardi et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Short poly(A) tails are a conserved feature of highly expressed genes

Sarah Azoubel Lima et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

添加到收藏夹

Article Infectious Diseases

A thermostable messenger RNA based vaccine against rabies

Lothar Stitz et al.

PLOS NEGLECTED TROPICAL DISEASES (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

Justin M. Richner et al.

CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Modified mRNA Vaccines Protect against Zika Virus Infection

Justin M. Richner et al.

CELL (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA

Mengnan Zhao et al.

DRUG DELIVERY (2016)

添加到收藏夹

Review Allergy

An overview on safety of monoclonal antibodies

Andrea Matucci et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2016)

添加到收藏夹

Article Immunology

Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial

Rajesh T. Gandhi et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2016)

添加到收藏夹

Article Immunology

Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Jeffrey M. Jacobson et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2016)

添加到收藏夹

Review Multidisciplinary Sciences

The evolution of Ebola virus: Insights from the 2013-2016 epidemic

Edward C. Holmes et al.

NATURE (2016)

添加到收藏夹

Review Multidisciplinary Sciences

Translational control by 5′-untranslated regions of eukaryotic mRNAs

Alan G. Hinnebusch et al.

SCIENCE (2016)

添加到收藏夹

Article Infectious Diseases

An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs

Margit Schnee et al.

PLOS NEGLECTED TROPICAL DISEASES (2016)

添加到收藏夹

Article Medicine, Research & Experimental

pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences

Alexandra E Grier et al.

Molecular Therapy-Nucleic Acids (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

mRNA vaccine delivery using lipid nanoparticles

Andreas M. Reichmuth et al.

THERAPEUTIC DELIVERY (2016)

添加到收藏夹

Article Microbiology

Epstein-Barr Virus

Andrew Nowalk et al.

MICROBIOLOGY SPECTRUM (2016)

添加到收藏夹

Article Microbiology

Cytomegalovirus

M. Veronica Dioverti et al.

MICROBIOLOGY SPECTRUM (2016)

添加到收藏夹

Editorial Material Pharmacology & Pharmacy

Ebola virus (EBOV) infection: Therapeutic strategies

Erik De Clercq

BIOCHEMICAL PHARMACOLOGY (2015)

添加到收藏夹

Article Microbiology

Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus

Scott A. Smith et al.

CELL HOST & MICROBE (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Norbert Pardi et al.

JOURNAL OF CONTROLLED RELEASE (2015)

添加到收藏夹

Article Virology

Everything You Always Wanted to Know About Rabies Virus (But Were Afraid to Ask)

Benjamin M. Davis et al.

ANNUAL REVIEW OF VIROLOGY, VOL 2 (2015)

添加到收藏夹

Review Microbiology

Ebola Virus: a Clear and Present Danger

Eileen M. Burd

JOURNAL OF CLINICAL MICROBIOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang et al.

NATURE (2014)

添加到收藏夹

Review Biotechnology & Applied Microbiology

mRNA-based therapeutics - developing a new class of drugs

Ugur Sahin et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5′-terminal regions of cap0-, cap1-and 5′ppp- mRNAs

Parimal Kumar et al.

NUCLEIC ACIDS RESEARCH (2014)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

Benjamin Petsch et al.

NATURE BIOTECHNOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

M. Diken et al.

GENE THERAPY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Katalin Kariko et al.

NUCLEIC ACIDS RESEARCH (2011)

添加到收藏夹

Review Virology

Antibody-mediated neutralization of flaviviruses: A reductionist view

Kimberly A. Dowd et al.

VIROLOGY (2011)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Katalin Kariko et al.

MOLECULAR THERAPY (2008)

添加到收藏夹

Review Medicine, General & Internal

Diagnostic evaluation of mononucleosis-like illnesses

Christopher Hurt et al.

AMERICAN JOURNAL OF MEDICINE (2007)

添加到收藏夹

Article Microbiology

The stoichiometry of antibody-mediated neutralization and enhancement of west nile virus infection

Theodore C. Pierson et al.

CELL HOST & MICROBE (2007)

添加到收藏夹

Article Hematology

Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells

Silke Holtkamp et al.

BLOOD (2006)

添加到收藏夹

Review Medicine, General & Internal

HIV/AIDS epidemiology, pathogenesis, prevention, and treatment

Viviana Simon et al.

LANCET (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

High guanine and cytosine content increases mRNA levels in mammalian cells

Grzegorz Kudla et al.

PLOS BIOLOGY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

mRNA transfection of dendritic cells:: Synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level

M Mockey et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

添加到收藏夹

Article Immunology

Suppression of RNA recognition by Toll-like receptors:: The impact of nucleoside modification and the evolutionary origin of RNA

K Karikó et al.

IMMUNITY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

SS Diebold et al.

SCIENCE (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

F Heil et al.

SCIENCE (2004)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Codon bias and heterologous protein expression

C Gustafsson et al.

TRENDS IN BIOTECHNOLOGY (2004)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Untranslated regions of mRNAs

Flavio Mignone et al.

GENOME BIOLOGY (2002)

添加到收藏夹

Article Multidisciplinary Sciences

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

L Alexopoulou et al.

NATURE (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.