Faecal microbiome transplantation improves clinical signs of chronic idiopathic large bowel diarrhoea in working dogs

BackgroundChronic diarrhoea is a common clinical sign in dogs with chronic enteropathy, and psyllium husk has been shown to improve clinical signs in affected dogs. The aim of this study was to investigate whether faecal microbiome transplant has a similar effect in alleviating clinical signs in dogs with chronic large bowel diarrhoea. MethodThirty large-breed working dogs with chronic large bowel diarrhoea were divided into a psyllium group (PG) and a faecal microbiome transplant group (FMTG). To the PG, 16 g/day of psyllium husk was administered for 30 days. The FMTG received faecal microbiome transplantation (FMT) once via enema. A daily log of faecal characteristics was kept, and the dogs' canine inflammatory bowel disease index (CIBDAI) and body condition scores (BCS) were determined. A Wilcoxon-Mann-Whitney test was used to compare group results. In addition, the Kaplan-Meier test was used to evaluate the occurrence rate of 1 day or more of diarrhoea and 2 days or more of diarrhoea by day 30. ResultsThe sample had a mean age of 3.9 +/- 2.1 years and a bodyweight of 25.3 +/- 6.8 kg. The FMTG showed a more rapid onset of CIBDAI improvement but no difference in other measures. At 30 days, the FMTG showed a greater improvement in bodyweight and BCS, but no differences were observed in faecal scores, defaecation frequency and time of appearance of episodes of diarrhoea. Time played a significant positive role in the results observed across both groups (p < 0.05). LimitationsThis study did not compare the microbiomes of the dogs before and after treatment, so the role of specific types of bacteria cannot be determined. ConclusionPsyllium husk and FMT had similar effects in improving clinical signs of chronic large bowel diarrhoea.

Automated summary

This study aimed to investigate whether faecal microbiome transplant has a similar effect in alleviating clinical signs in dogs with chronic large bowel diarrhea. The results showed that both psyllium husk and FMT had similar effects in improving clinical signs, but no differences were observed in faecal scores, defaecation frequency, and time of appearance of episodes of diarrhea. Time played a significant positive role in the results observed across both groups.