Protein disulfide isomerases-a way to tackle malaria

Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly folded. PDI activity plays an essential role in malaria transmission. Here we pro-vide an overview of the role of PDIs in malaria-causing Plasmodium parasites and outline why PDI inhi-bition could be a novel way to treat malaria and prevent transmission.

Automated summary

Protein disulfide isomerases (PDIs) play a crucial role in ensuring the proper folding of specific substrate proteins and are important for malaria transmission. This article provides an overview of the involvement of PDIs in malaria-causing Plasmodium parasites and discusses the potential of PDI inhibition as a novel approach for malaria treatment and prevention.