Obesity wars: hypothalamic sEVs a new hope

Article Endocrinology & Metabolism

Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice

Edward Milbank et al.

Summary: The study found that using a specific type of extracellular vesicles loaded with a defective AMPK alpha 1 gene can alleviate symptoms such as obesity and metabolic disorders in mice.

METABOLISM-CLINICAL AND EXPERIMENTAL (2023)

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Article Cell Biology

Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist

Martin Bossart et al.

Summary: Unimolecular triple incretins have shown efficacy in reducing body weight and improving glucose control. SAR441255, a synthetic peptide agonist, activates GLP-1, GCG, and GIP receptors with balanced potency, demonstrating superior metabolic outcomes compared to dual agonists in animal models.

CELL METABOLISM (2022)

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Review Biotechnology & Applied Microbiology

Anti-obesity drug discovery: advances and challenges

Timo D. Mueller et al.

Summary: Enormous progress has been made in managing diseases associated with excess body weight, but treatment of obesity itself remains challenging. By summarizing the history and advancements in anti-obesity medications, researchers are now pursuing next-generation AOMs that could safely and effectively achieve weight loss.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Review Instruments & Instrumentation

Exosomal targeting and its potential clinical application

Jiao He et al.

Summary: Exosomes, as extracellular vesicles secreted by living cells, possess natural targeting as nano-carriers for drug delivery systems. However, the natural targeting alone is insufficient for precise delivery, requiring engineering transformation and modification to optimize targeting efficiency.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Review Pharmacology & Pharmacy

Why nanoparticles prefer liver macrophage cell uptake in vivo

Wayne Ngo et al.

Summary: The accumulation of nanoparticles in diseased tissues is crucial for effective therapy and diagnosis. However, most nanoparticles end up being captured by liver macrophages after administration. This review describes the interactions between liver macrophages and nanoparticles, highlighting the advantages of liver macrophages in interacting with circulating nanoparticles.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Endocrinology & Metabolism

Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus

Alexander Jais et al.

Summary: The central nervous system plays a crucial role in maintaining metabolic homeostasis and regulating various physiological functions through the ARC. Energy state-sensing neurons in the ARC are master regulators that control feeding, glucose homeostasis, and other physiological responses based on the organism's energy status.

ENDOCRINE REVIEWS (2022)

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Review Endocrinology & Metabolism

Mechanisms of Weight Loss After Obesity Surgery

Elina Akalestou et al.

Summary: Obesity surgery is the most effective treatment for obesity and its complications, and mechanisms related to weight loss include central appetite control, release of gut peptides, change in microbiota, and bile acids. However, the exact combination and timing of signals remain largely unknown.

ENDOCRINE REVIEWS (2022)

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Review Genetics & Heredity

The genetics of obesity: from discovery to biology

Ruth J. F. Loos et al.

Summary: In this review, Loos and Yeo summarize our current understanding of the genetic underpinnings of monogenic and polygenic obesity, highlighting shared genetic and biological underpinnings between the two forms of obesity. Genome-wide association studies with increasing sample sizes have driven recent discoveries, with post-GWAS collaborations facilitating translation of genetic loci into meaningful biology and new treatment avenues.

NATURE REVIEWS GENETICS (2022)

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Editorial Material Endocrinology & Metabolism

Exosomes as novel biomarkers in metabolic disease and obesity-related cancers

Naser Jafari et al.

Summary: Exosomes are plasma-transported vesicles secreted by human tissues that reflect metabolic status. The profile of exosomes, particularly the microRNA content, is altered in metabolic diseases. In type 2 diabetes mellitus, circulating exosomes in plasma can induce transcriptional changes related to tumor progression and pro-metastatic phenotypes in target cancer cells, potentially linking obesity to cancer progression and metastasis.

NATURE REVIEWS ENDOCRINOLOGY (2022)

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Review Pharmacology & Pharmacy

Hypothalamic AMPK as a possible target for energy balance-related diseases

Miguel Lopez

Summary: Hypothalamic AMP-activated protein kinase (AMPK) plays a crucial role in regulating energy balance and metabolism at the whole-body level. Targeting AMPK within the hypothalamus using small extracellular vesicles (sEVs) is a potential strategy for modulating both food intake and energy expenditure, offering treatment options for energy balance-related diseases.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

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Review Chemistry, Multidisciplinary

Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake

Ilgin Kimiz-Gebologlu et al.

Summary: This review discusses the general properties and biological functions of exosomes, as well as their potential in drug delivery systems. It provides an overview of methods for large-scale production, isolation, and drug loading of exosomes, and investigates the current challenges and potential directions in this emerging field of drug delivery.

JOURNAL OF CONTROLLED RELEASE (2022)

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Editorial Material Endocrinology & Metabolism

What's preventing us from curbing the obesity crisis?

[Anonymous]

LANCET DIABETES & ENDOCRINOLOGY (2022)

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Review Cell Biology

Biological Features of Extracellular Vesicles and Challenges

Ye Zeng et al.

Summary: Extracellular vesicles (EVs) are lipid bilayer membrane vesicles containing DNA, RNA, lipids and proteins, which play important roles in the pathophysiological processes of various diseases. This study discusses the advantages of EVs and the challenges associated with their application, proposing solutions to facilitate their clinical use.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Cell Biology

A review on exosomes application in clinical trials: perspective, questions, and challenges

Jafar Rezaie et al.

Summary: Exosomes, as significant mediators of cell-to-cell communication, have promising applications in the treatment of various diseases. They can be used as biomarkers, cell-free therapeutic agents, and drug delivery carriers. However, there are challenges to overcome in the clinical application of exosomes, and further research and standardization are needed.

CELL COMMUNICATION AND SIGNALING (2022)

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Article Pharmacology & Pharmacy

Oral administration of zein-based nanoparticles reduces glycemia and improves glucose tolerance in rats

Cristian Reboredo et al.

Summary: The study evaluated the impact of zein-based nanoparticles on glucose homeostasis in Wistar rats. The results showed that these nanoparticles could significantly decrease blood glucose levels and improve glucose tolerance. This effect may be attributed to the increased release of glucagon-like peptide-1 (GLP-1) induced by the nanoparticles.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Endocrinology & Metabolism

Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue

Ricardo J. Samms et al.

Summary: Tirzepatide improves insulin sensitivity in T2D patients and obese mice by promoting the catabolism of BCAAs in BAT, resulting in reduced systemic levels of BCAAs and changes in the thermogenic amino acid profile in BAT.

MOLECULAR METABOLISM (2022)

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Review Chemistry, Multidisciplinary

Exosomes-Nature's Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

Rumiana Tenchov et al.

Summary: This article provides an overview of the applications of exosomes in therapeutics and diagnostics, analyzing their properties, isolation methods, clinical applications, and development pipelines. These studies contribute to the further development of the potential of exosomes in medical applications.

ACS NANO (2022)

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Article Endocrinology & Metabolism

HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus

Lukas Steuernagel et al.

Summary: The hypothalamus plays a crucial role in coordinating fundamental body functions, but there is still a lack of unified catalog and molecular characterization of neuronal subtypes in this brain region. The integrated reference atlas "HypoMap" provides a systematic framework for functional annotation of hypothalamic cell types, serving as a crucial platform for unraveling the functional organization of hypothalamic neurocircuits and identifying druggable targets for treating metabolic disorders.

NATURE METABOLISM (2022)

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Article Medicine, General & Internal

Tirzepatide Once Weekly for the Treatment of Obesity

Ania M. Jastreboff et al.

Summary: In this 72-week trial in participants with obesity, once-weekly doses of 5 mg, 10 mg, or 15 mg of tirzepatide provided substantial and sustained reductions in body weight, and improvements in cardiometabolic measures were also observed.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Review Chemistry, Multidisciplinary

Challenges in the development and establishment of exosome-based drug delivery systems

Jin Wang et al.

Summary: Exosomes, as potential drug delivery vehicles, have been studied extensively, but face multiple technical challenges, including isolation, characterization, and stability testing, as well as challenges related to drug cell-uptake, loading, release, and in vivo distribution.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Pharmacology & Pharmacy

Nicotine' actions on energy balance: Friend or foe?

Patricia Seoane-Collazo et al.

Summary: Nicotine exerts significant regulatory effects on energy balance through various pathways, affecting body weight and energy metabolism, and may have potential value as a complementary approach to obesity treatment given the limited efficiency of current therapies.

PHARMACOLOGY & THERAPEUTICS (2021)

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Review Endocrinology & Metabolism

Novel Noninvasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy

Angeliki M. Angelidi et al.

Summary: Recent research on the pathophysiology of obesity has led to the discovery of promising drug targets and novel therapeutic strategies. Current pharmacologic options for obesity management are limited, highlighting the urgent need for safe and more effective new agents. Beyond pharmacotherapeutics, alternative anti-obesity strategies are being explored to ultimately develop safe, effective, and sustainable weight loss methods.

ENDOCRINE REVIEWS (2021)

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Article Pharmacology & Pharmacy

Dissolving microneedle-assisted long-acting Liraglutide delivery to control type 2 diabetes and obesity

Morteza Rabiei et al.

Summary: Integrating nanoparticles with dissolving microneedles creates a promising non-invasive drug delivery device that provides sustained release and eliminates the need for subcutaneous injection, while also enhancing mechanical strength. The flexible backing layer obtained through blending of PVP and PVA, maintains the native secondary structure of the encapsulated drug according to CD analysis.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Medicine, General & Internal

Once-Weekly Semaglutide in Adults with Overweight or Obesity

John P. H. Wilding et al.

Summary: The study demonstrates that for individuals with obesity, once-weekly use of 2.4 mg semaglutide in combination with lifestyle intervention can lead to sustained and clinically relevant weight loss, with significant improvements in cardiometabolic risk factors and physical functioning reported by participants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Development and Characterization of PLGA Nanoparticles Containing 17-DMAG, an Hsp90 Inhibitor

Kercia P. Cruz et al.

Summary: This study developed PLGA nanoparticles containing 17-DMAG using a double emulsion method, with P2 nanoparticles being smaller and more homogeneous than P1. The optimized formulation consisted of 2 mg 17-DMAG, 100 mg PLGA, 5% PEG 8000, 1.5 mL internal aqueous phase, 1% PVA, and 4 mL organic phase, showing promising release kinetics and cell uptake properties.

FRONTIERS IN CHEMISTRY (2021)

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Review Engineering, Biomedical

The evolution of commercial drug delivery technologies

Ava M. Vargason et al.

Summary: This review article discusses how challenges in delivering small molecules, nucleic acids, peptides, proteins, and cells have led to the development of commercial products and are now guiding the delivery of live-cell therapeutics. Drug delivery technologies have enabled the development of pharmaceutical products that enhance therapeutic delivery, minimize off-target effects, and improve patient compliance. Three drug delivery paradigms have been developed to aid in the successful delivery of small molecules and macromolecules, contributing to the initial clinical success of each therapeutic class.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Pharmacology & Pharmacy

Lipid based nanocarriers for effective drug delivery and treatment of diabetes associated liver fibrosis

Shubham A. Salunkhe et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) encompasses a range of liver diseases that can progress to liver cancer, with diabetes mellitus being a key factor in its development. Liver fibrosis treatment involves the use of lipid nanoparticles, while the effects of elevated free fatty acids, insulin resistance, and diabetes on pathogenesis are also important considerations. Targeting hepatic stellate cells has been explored as a strategy for treating liver fibrosis.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes

Anna Fosch et al.

Summary: SF1 neurons in the ventromedial hypothalamus play a crucial role in sensing glucose levels and mediating insulin and leptin signaling, as well as in energy expenditure and glucose homeostasis, particularly in the early stages of obesity. While studies have provided insight into the central role of these neurons in whole-body energy homeostasis, they have also raised new questions regarding the existence of neuronal sub-populations and the complexity of neurocircuitry.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Polymer Science

A Comprehensive Review on the Applications of Exosomes and Liposomes in Regenerative Medicine and Tissue Engineering

Mojtaba Shafiei et al.

Summary: Liposomes and exosomes play crucial roles in drug delivery systems and disease treatments in nanomedicine. Exosomes, with higher bioactivity and stability compared to liposomes, have significant potential in disease therapy and prognosis.

POLYMERS (2021)

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Article Biology

Cross-species analysis defines the conservation of anatomically segregated VMH neuron populations

Alison H. Affinati et al.

Summary: Research has identified multiple clusters of VMH neurons in both mouse and macaque tissues, divided into six main classes with good cross-species conservation. The expression of leptin receptor (Lepr) marks a specific category of VMH neurons.

ELIFE (2021)

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Article Endocrinology & Metabolism

Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation

Edward Milbank et al.

Summary: Milbank et al. demonstrate that targeted delivery of AMPK alpha 1 in SF1 neurons of the VMH using small extracellular vesicles can lead to weight loss through increased brown adipose tissue thermogenesis, independent of feeding.

NATURE METABOLISM (2021)

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Review Endocrinology & Metabolism

POMC neuronal heterogeneity in energy balance and beyond: an integrated view

Carmelo Quarta et al.

Summary: The study discusses the impact of different subpopulations of POMC neurons on appetite, whole-body metabolic physiology, and the development of obesity, proposing a conceptual framework that integrates POMC neuronal heterogeneity with appetite regulation, whole-body metabolic physiology, and obesity development. It highlights the emerging evidence of how POMC neurons respond to distinct combinations of interoceptive signals and food-related cues, indicating their developmental plasticity.

NATURE METABOLISM (2021)

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Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

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Article Cardiac & Cardiovascular Systems

Liraglutide decreases energy expenditure and does not affect the fat fraction of supraclavicular brown adipose tissue in patients with type 2 diabetes

Huub J. van Eyk et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Chemistry, Physical

Nanostructured polymer-based cochleates for effective transportation of insulin

Rohan Khair et al.

JOURNAL OF MOLECULAR LIQUIDS (2020)

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Review Neurosciences

Recent Updates on Obesity Treatments: Available Drugs and Future Directions

Nathalia R. V. Dragano et al.

NEUROSCIENCE (2020)

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Review Biotechnology & Applied Microbiology

Recent Advancements in the Loading and Modification of Therapeutic Exosomes

Mengqiao Xu et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Liposome-encapsulated peptide PDBSN ameliorates high-fat-diet-induced obesity and improves metabolism homeostasis

Dan Shen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Oncology

The evolving translational potential of small extracellular vesicles in cancer

Andreas Moller et al.

NATURE REVIEWS CANCER (2020)

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Review Biotechnology & Applied Microbiology

AMP-activated protein kinase: the current landscape for drug development

Gregory R. Steinberg et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Review Engineering, Biomedical

Nanotechnology-Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities

Yung-Hao Tsou et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Review Pharmacology & Pharmacy

Recent advances of microneedles for biomedical applications: drug delivery and beyond

Jian Yang et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Review Biochemistry & Molecular Biology

Exosomes

D. Michiel Pegtel et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

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Review Medicine, Research & Experimental

Microneedles: A smart approach and increasing potential for transdermal drug delivery system

Tejashree Waghule et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Neurosciences

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

Cristina Garcia-Caceres et al.

NATURE NEUROSCIENCE (2019)

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Article Nanoscience & Nanotechnology

Glucose- and H2O2-Responsive Polymeric Vesicles Integrated with Microneedle Patches for Glucose-Sensitive Transcutaneous Delivery of Insulin in Diabetic Rats

Zaizai Tong et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Cell Biology

AMPK: Sensing Glucose as well as Cellular Energy Status

Sheng-Cai Lin et al.

CELL METABOLISM (2018)

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Editorial Material Pharmacology & Pharmacy

The potential of a microneedle patch for reducing obesity

Yuqi Zhang et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

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Article Chemistry, Multidisciplinary

Effect of obesity on biodistribution of nanoparticles

Claudiana de Jesus Felismino et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Cell Biology

Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat

Shiki Okamoto et al.

CELL REPORTS (2018)

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Article Endocrinology & Metabolism

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

Patricia Seoane-Collazo et al.

DIABETES (2018)

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Review Pharmacology & Pharmacy

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

T. D. Mueller et al.

PHARMACOLOGICAL REVIEWS (2018)

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Article Materials Science, Biomaterials

Poly(ester amide)-based hybrid hydrogels for efficient transdermal insulin delivery

Shaohan Zhang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Medicine, General & Internal

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

Juan Pablo Frias et al.

LANCET (2018)

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Article Chemistry, Multidisciplinary

Oral delivery of a therapeutic gene encoding glucagon-like peptide 1 to treat high fat diet-induced diabetes

Md Nurunnabi et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Biotechnology & Applied Microbiology

Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity

Chunhui Jiang et al.

MOLECULAR THERAPY (2017)

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Article Neurosciences

A molecular census of arcuate hypothalamus and median eminence cell types

John N. Campbell et al.

NATURE NEUROSCIENCE (2017)

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Review Physiology

Optogenetics and pharmacogenetics: principles and applications

Jingwei Jiang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2017)

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Article Engineering, Biomedical

Visceral adipose tissue macrophage-targeted TACE silencing to treat obesity-induced type 2 diabetes

Seok-Beom Yong et al.

BIOMATERIALS (2017)

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Article Cell Biology

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

Carmelo Quarta et al.

CELL METABOLISM (2017)

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Article Endocrinology & Metabolism

Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 in people with type 2 diabetes mellitus

Christophe Schmitt et al.

DIABETES OBESITY & METABOLISM (2017)

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Article Chemistry, Multidisciplinary

Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment

Yuqi Zhang et al.

ACS NANO (2017)

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Article Cell Biology

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

Noelia Martinez-Sanchez et al.

CELL METABOLISM (2017)

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Article Chemistry, Multidisciplinary

Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers

Liang Ma et al.

ACS NANO (2016)

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Article Biochemistry & Molecular Biology

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Brian Finan et al.

CELL (2016)

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Review Biochemistry & Molecular Biology

In vitro release kinetics model fitting of liposomes: An insight

Ankit Jain et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2016)

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Article Endocrinology & Metabolism

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

M. Sahuri-Arisoylu et al.

INTERNATIONAL JOURNAL OF OBESITY (2016)

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Review Medicine, Research & Experimental

Exosomes and tumor-mediated immune suppression

Theresa L. Whiteside

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Chemistry, Multidisciplinary

Injectable insulin-lysozyme-loaded nanogels with enzymatically-controlled degradation and release for basal insulin treatment: In vitro characterization and in vivo observation

Hao-Syun Chou et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Chemistry, Physical

The surface science of nanocrystals

Michael A. Boles et al.

NATURE MATERIALS (2016)

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Review Endocrinology & Metabolism

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

Miguel Lopez et al.

NATURE REVIEWS ENDOCRINOLOGY (2016)

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Article Cell Biology

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance

Luis Martins et al.

CELL REPORTS (2016)

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Review Nanoscience & Nanotechnology

Designing hydrogels for controlled drug delivery

Jianyu Li et al.

NATURE REVIEWS MATERIALS (2016)

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Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

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Review Pharmacology & Pharmacy

Advances and Challenges of Liposome Assisted Drug Delivery

Lisa Sercombe et al.

FRONTIERS IN PHARMACOLOGY (2015)

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Article Cell Biology

Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

Pablo B. Martinez de Morentin et al.

CELL METABOLISM (2014)

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Article Endocrinology & Metabolism

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

Daniel Beiroa et al.

DIABETES (2014)

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Review Chemistry, Multidisciplinary

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

Sutapa Barua et al.

NANO TODAY (2014)

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Review Biotechnology & Applied Microbiology

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

Samir Mitragotri et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

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Article Rheumatology

Nanoparticles and the Mononuclear Phagocyte System: Pharmacokinetics and Applications for Inflammatory Diseases

Gina Song et al.

CURRENT RHEUMATOLOGY REVIEWS (2014)

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Review Chemistry, Multidisciplinary

The Role of Surface Functionality in Determining Nanoparticle Cytotoxicity

Sung Tae Kim et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

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Article Multidisciplinary Sciences

Involvement of Hypothalamic AMP-Activated Protein Kinase in Leptin-Induced Sympathetic Nerve Activation

Mamoru Tanida et al.

PLOS ONE (2013)

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Article Biochemistry & Molecular Biology

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

Andrew J. Whittle et al.

CELL (2012)

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Article Biochemistry & Molecular Biology

Targeted estrogen delivery reverses the metabolic syndrome

Brian Finan et al.

NATURE MEDICINE (2012)

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Article Biochemical Research Methods

Exosome-mediated delivery of siRNA in vitro and in vivo

Samir El-Andaloussi et al.

NATURE PROTOCOLS (2012)

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Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

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Article Instruments & Instrumentation

Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin

Pedro Fonte et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2011)

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Article Biochemistry & Molecular Biology

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

Ricardo Lage et al.

FASEB JOURNAL (2010)

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Review Cell Biology

Molecular aspects of steroidogenic factor 1 (SF-1)

Erling A. Hoivik et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2010)

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Article Biochemistry & Molecular Biology

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

Miguel Lopez et al.

NATURE MEDICINE (2010)

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Article Engineering, Biomedical

Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery

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