期刊
TRENDS IN BIOTECHNOLOGY
卷 41, 期 10, 页码 1237-1247出版社
CELL PRESS
DOI: 10.1016/j.tibtech.2023.03.020
关键词
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Animal breeding progresses mainly through the male germline, but this process responds slowly to environmental pressures. New breeding approaches using chimaeras can accelerate breeding and transmit elite male germlines. We propose a novel breeding platform that integrates embryo-based complementation, genomic selection, multiplication, and gene modification.
Animal breeding drives genetic progress mainly through the male germline. This process is slow to respond to rapidly mounting environmental pressures that threaten sustainable food security from animal protein production. New approaches promise to accelerate breeding by producing chimaeras, which comprise sterile host and fertile donor genotypes, to exclusively transmit elite male germlines. Following gene editing to generate sterile host cells, the missing germline can be restored by transplanting either: (i) spermatogonial stem cells (SSCs) into the testis; or (ii) embryonic stem cells (ESCs) into early embryos. Here we compare these alternative germline complementation strategies and their impact on agribiotechnology and species conservation. We propose a novel breeding platform that integrates embryo-based complementation with genomic selection, multiplication, and gene modification.
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