Preliminary Observations of An Ex Vivo Normothermic Whole Blood Machine Perfusion in An Experimental Liver Transplant Porcine Model

Article Surgery

Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant The OCS Liver PROTECT Randomized Clinical Trial

James F. Markmann et al.

Summary: This multicenter randomized clinical trial demonstrates that normothermic machine perfusion preservation of deceased donor livers reduces both early allograft dysfunction and ischemic biliary complications in liver transplant recipients, and increases the utilization of livers from donors after cardiac death.

JAMA SURGERY (2022)

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Article Transplantation

Rapid Metabolic Recovery of Donor Circulatory Death Liver Graft Using Whole Blood Perfusion: A Pig Study

Syuhei Yoshimoto et al.

Summary: The study compared the ex vivo metabolic characteristics of porcine DCD livers perfused with whole or diluted blood to evaluate their initial response to resuscitation, finding that whole blood perfusion resulted in metabolic trends similar to the in vivo model, while diluted blood perfusion led to increased metabolism during perfusion. Further research is needed in this area to improve the utilization of DCD organs.

TRANSPLANTATION DIRECT (2021)

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Article Medicine, General & Internal

Hypothermic Machine Perfusion in Liver Transplantation - A Randomized Trial

R. Van Rijn et al.

Summary: This study demonstrated that hypothermic oxygenated machine perfusion can reduce the risk of nonanastomotic biliary strictures following liver transplantation from donors after circulatory death, with lower rates of complications compared to conventional static cold storage.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Biotechnology & Applied Microbiology