4.6 Article

Health-related Quality of Life and Fatigue in Liver Transplant Recipients Receiving Tacrolimus Versus Sirolimus-based Immunosuppression: Results From a Randomized Trial

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Article Gastroenterology & Hepatology

Three-year results of renal function in liver transplant recipients on low-dose sirolimus and tacrolimus: a multicenter, randomized, controlled trial

Midas B. Mulder et al.

Summary: The aim of this study was to compare the effects of low-dose sirolimus and low-dose extended-release tacrolimus with normal-dose extended-release tacrolimus on renal function and rejection, graft and patient survival rates at 36 months after transplantation. This was an open-label, multicenter randomized controlled trial. The study found that there was no significant difference in the incidence of chronic kidney disease at 36 months between the groups, but in the intention-to-treat population, the interventional group had higher estimated glomerular filtration rate at 6 months.

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