期刊
TRANSLATIONAL RESEARCH
卷 259, 期 -, 页码 35-45出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2023.04.002
关键词
Biomarkers; Calcific aortic stenosis; Diabetes mellitus; Personalized medicine; Proteomics
Diabetes mellitus (DM) increases the risk of severe calcific aortic stenosis (CAS), but the relationship between these two diseases and the impact of DM on CAS progression is unclear. In this study, we analyzed calcified and noncalcified valve tissue from patients with severe CAS, with or without DM, using a proteomic strategy. We found that DM induces changes in the proteome of aortic valves, affecting valve calcification. This finding provides valuable insights into the pathogenesis of CAS and the personalized treatment of patients with both DM and CAS.
Diabetes mellitus (DM) and calcific aortic stenosis (CAS) are common morbidities in the elderly, which are both chronic, progressive and often concomitant diseases. Several studies revealed that DM increases the risk of developing severe CAS, yet clear information about the relationship between both these diseases and the influence of DM on the progression of CAS is currently lacking. To evaluate the effect of DM on aortic valves and on the process of calcification, and to achieve better patient management in daily clinical practice, we analysed calcified and noncalcified valve tissue from patients with severe CAS, with or without DM. A proteomic strategy using isobaric tags was adopted and the plasma concentrations of nine proteins were studied using 3 orthogonal methods and in a separate cell model. The differentially expressed proteins identified are implicated in biological processes like endopeptidase activity, lipid metabolism, coagulation, and fibrinolysis. The results obtained provide evidence that DM provokes changes in the proteome of aortic valves, affecting valve calcification. This finding may help enhance our understanding of the pathogenesis of CAS and how DM affects the evolution of this condition, an important step in identifying targets to personalize the treatment of these patients.
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