4.4 Review

Endodontic Tissue Regeneration: A Review for Tissue Engineers and Dentists

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Gelatin methacryloyl-alginate core-shell microcapsules as efficient delivery platforms for prevascularized microtissues in endodontic regeneration

Xi Liang et al.

Summary: This study successfully fabricated GelMA-alginate core-shell microcapsules using a novel preparation technique, and co-cultured human dental pulp stem cells (hDPSCs) and human umbilical vein endothelial cells (HUVECs) in them. In the microcapsules, the co-culture group showed higher cell proliferation rates and the formation of 3D capillary-like networks. Furthermore, the co-culture group exhibited enhanced osteo/odontogenic differentiation. In vivo experiments confirmed better microvessel formation and pulp-like tissue regeneration in the co-culture group.

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hDPSC-laden GelMA microspheres fabricated using electrostatic microdroplet method for endodontic regeneration

Ting Yang et al.

Summary: The use of GelMA microspheres as cell delivery vehicles in endodontic regeneration shows great potential due to their excellent bioactivity and biodegradability. Encapsulated dental pulp stem cells in the microspheres demonstrate functions such as adhesion, proliferation, and extracellular matrix protein secretion, leading to the generation of more vascularized pulp-like tissues in vivo.

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Leopoldina D. F. Almeida et al.

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W. J. Wolters et al.

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Jidapa Silujjai et al.

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H. Nakayama et al.

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