Three-Dimensional Cell Culture System for Tendon Tissue Engineering

Tendon, connective tissue between bone and muscle has unique component of the musculoskeletal system. It plays important role for transporting mechanical stress from muscle to bone and enabling locomotive motion of the body. There are some restoration capacities in the tendon tissue, but the injured tendons are not completely regenerated after acute and chronic tendon injury. At this point, the treatment options for tendon injuries are limited and not that successful. Therefore, biomedical engineering approaches are emerged to cope with this issue. Among them, three-dimensional cell culture platforms provided similarity to in vivo conditions and suggested opportunities for new therapeutic approaches for treatment of tendon injuries. In this review, we focus on the characteristics of tendon tissue and tendon pathologies which can be targets for tendon tissue engineering strategies. Then proof-of-concept and pre-clinical studies leveraging advanced 3-dimensional cell culture platforms for tendon tissue regeneration have been discussed.

Automated summary

Tendon is a unique component of the musculoskeletal system that plays a crucial role in transmitting mechanical stress and enabling locomotor motion. Current treatment options for tendon injuries are limited and not very successful, leading to the emergence of biomedical engineering approaches. Three-dimensional cell culture platforms provide a more realistic environment and offer opportunities for new therapeutic strategies for tendon tissue regeneration.