期刊
THROMBOSIS RESEARCH
卷 225, 期 -, 页码 95-100出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2023.03.015
关键词
Thromboelastography; Reaction time; Endovascular treatment; Hypercoagulability; Ischemic stroke
Thromboelastography (TEG) can be used to predict functional outcome in acute large vessel occlusive stroke patients undergoing intraarterial thrombectomy (IAT), with decreased reaction time (R) associated with improved functional independence.
Background: Thromboelastography (TEG) is a useful for predicting hemorrhagic transformation, early neuro-logical deterioration, and functional outcome after stroke. We aimed to investigate whether TEG value could also be useful in predicting functional outcome via various intraprocedural and postprocedural factors in patients with acute large vessel occlusive stroke who underwent intraarterial thrombectomy (IAT).Methods: Patients with ischemic stroke who underwent IAT between March 2018 and March 2020 at two tertiary hospitals were included. The association between reaction time (R) and functional outcome was evaluated. The primary outcome was the achievement of functional independence defined as the achievement of a modified Rankin Scale (mRS) score of 0-2 at 3 months after the index stroke. Results: Among a total of 160 patients (mean age, 70.6 +/- 12.3 years; 103 [64.4 %] men), 79 (49.3 %) achieved functional independence at 3 months. R, both as a continuous (odds ratio [OR]: 1.45, 95 % confidence interval [95 % CI]: 1.09-1.92, P = 0.011) and dichotomized parameters (R < 5 min [OR: 0.37, 95 % CI: 0.16-0.82, P = 0.014]), were inversely associated with increased odds of achieving functional independence (mRS score 0-2) after multivariable analysis. The association was still consistent when the outcome was the achievement of disability free (mRS score 0-1) or mRS score analyzed as an ordinal variable.Conclusions: Decreased R, especially R < 5 min, was inversely associated with functional outcome pf stroke after EVT.
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