Rhenium complex-catalyzed N-allylation and N-benzylation of amines with alcohols

When aliphatic amines were allowed to react with allylic alcohols in the presence of a catalytic amount of a rhenium complex, the N-allylation of aliphatic amines efficiently proceeded to give the corresponding N-allyl substituted amines in moderate to good yields. Similarly, the N-benzylation of an amine with ben-zylic alcohols occurred in the presence of the rhenium catalyst. (c) 2023 Elsevier Ltd. All rights reserved.

Automated summary

When aliphatic amines were reacted with allylic alcohols in the presence of a rhenium catalyst, efficient N-allylation of aliphatic amines occurred, providing the corresponding N-allyl substituted amines in moderate to good yields. Similarly, the N-benzylation of an amine with benzylic alcohols could proceed in the presence of the rhenium catalyst.