One-pot synthesis of 2,6-diaryl-4,5-dihydropyridazin-3(2H)-ones: Copper catalyzed annulation of aldehydes, arylhydrazines and 3-acryloyloxazolidin-2-one

The three-component synthesis of pyridazinones from aldehydes, arylhydrazines and 3-acryloyloxazo-lidin-2-one catalyzed by Cu(OTf)2 has been developed. This strategy exhibits high tolerance towards many functional groups including various aliphatic, aromatic and hetero-aromatic aldehydes to give 2,6-diaryl-4,5-dihydropyridazin-3(2H)-one products in moderate to high yields.(c) 2023 Elsevier Ltd. All rights reserved.

Automated summary

A three-component synthesis of pyridazinones using Cu(OTf)2 as catalyst has been developed, which shows high tolerance towards various functional groups including aliphatic, aromatic and hetero-aromatic aldehydes, and gives moderate to high yields of 2,6-diaryl-4,5-dihydropyridazin-3(2H)-one products.