Practical synthesis of 5H-pyrido[2',1:2,3]imidazo[4,5-b]indoles by Cu- catalyzed double C-N coupling reactions

Fluorescent active small molecules containing 5H-pyrido [12',1':2,3]imidazo [4,5-b]indole core could be successfully prepared by Cu-catalyzed double C-N coupling reaction from 3-bromo-2-(2-bromophenyl) imidazo [1,2-a]pyridine with different amines in high yields. DMSO, a green solvent played a key role for the success of this double C-N coupling reaction. This method may find potential applications not only in pharmaceutical chemistry but also in materials science. (c) 2023 Published by Elsevier Ltd.

Automated summary

Fluorescent active small molecules containing 5H-pyrido [12',1':2,3]imidazo [4,5-b]indole core were successfully synthesized via Cu-catalyzed double C-N coupling reaction from 3-bromo-2-(2-bromophenyl) imidazo [1,2-a]pyridine with various amines in high yields. DMSO, a green solvent, played a crucial role in the success of this reaction. This method has potential applications in pharmaceutical chemistry and materials science.