Oxidative C-N Bond Cleavage of Cyclic Amines with Ammonium Hypochlorite

Article Chemistry, Organic

Divergent Electrochemical Carboamidation of Cyclic Amines

Feijun Wang et al.

Summary: We have developed an electrochemical carboamidation sequence that can produce different products through direct functionalization or ring opening reactions. The nature of the N-acyl activating group determines the reaction pathway. Both methods are one-pot reactions and can generate peptide-like products with increased molecular complexity.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold

Hengxi Zhang et al.

Summary: DC-SIGN is a pattern recognition receptor expressed on immune cells that recognizes carbohydrate signatures on pathogens. This study focuses on developing inhibitors that can block the carbohydrate-binding site of DC-SIGN. By screening a library of compounds and validating the data, the researchers identified certain compounds with favorable binding activity and demonstrated their ability to modulate the carbohydrate binding site.

ACS MEDICINAL CHEMISTRY LETTERS (2022)

添加到收藏夹

Article Chemistry, Organic

Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides

Shweta K. Gediya et al.

Summary: The study successfully achieved the asymmetric transfer hydrogenation (ATH) of alpha-keto-1,4-diamides using a tethered Ru/TsDPEN catalyst with high enantiomeric excess. By investigating derivatives, the structural elements leading to the highest enantioselectivities in the products were identified, and the reduction products were further converted into a variety of synthetically valuable derivatives.

ORGANIC LETTERS (2021)

添加到收藏夹

Article Chemistry, Applied