期刊
SYNTHESIS-STUTTGART
卷 -, 期 -, 页码 -出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-2062-8680
关键词
C-N bond cleavage; oxidation; cyclic amines; ammonium hypochlorite; amino acids
A metal-free oxidative C-N bond cleavage of cyclic amines has been developed to provide N-Cl-?-amino acids in moderate to excellent yields. The reactions can proceed even on a gram scale using tetramethylammonium hypochlorite (TMAOCl) as an oxidant. Furthermore, the Hofmann-Loffler-Freytag-type reaction of N-Cl-?-amino acids to form cyclic amino acids has been demonstrated.
An oxidative C-N bond cleavage of cyclic amines has been developed under metal-free conditions, providing N-Cl-?-amino acids in moderate to excellent yields. The reactions proceed by using tetramethylammonium hypochlorite (TMAOCl) as an oxidant even on a gram scale. Hofmann-Loffler-Freytag-type reaction of N-Cl-?-amino acids to form cyclic amino acids has also been demonstrated.
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