☆ 4.5 Article

Synthesis of Quinoline and Quinolin-2(1H )-one Derivatives via Nickel Boride Promoted Reductive Cyclization

SYNTHESIS-STUTTGART (2023)

Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases

Kadarkarai Murugan et al.

Summary: Mosquito borne diseases are a global concern due to their fast spread and the lack of effective treatments. This study focuses on the development of a novel compound that can act as an anti-malarial and anti-viral agent while also targeting the vectors. The synthesized quinoline derivative showed significant larvicidal and pupicidal properties against malaria and dengue vectors, as well as potent antiplasmodial activity against sensitive strains of Plasmodium falciparum.

SCIENTIFIC REPORTS (2022)

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Article Chemistry, Organic