☆ 4.5 Article

Rh-Catalyzed C-H Functionalization of the (Pyrazol-5-yl)pyridine Core of GBT-440

SYNTHESIS-STUTTGART (2023)

Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins br

Rupali G. Kalshetti et al.

Summary: The directed Rh(III)-catalyzed cross dehydrogenative coupling of the pyrazole unit of the GBT-440 scaffold has been explored to synthesize post-functionalized GBT-440 analogues using simple and conjugated olefins. Screening of these compounds for improving the oxygen binding efficiency of sickled red blood cell isolated hemoglobin revealed that some of them are as good as GBT-440.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)

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Article Medicine, General & Internal

First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer

Alice T. Shaw et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds

Wen Ai et al.

CHEMISTRY-A EUROPEAN JOURNAL (2014)

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Article Chemistry, Organic

Rhodium-Catalyzed Mono- and Divinylation of 1-Phenylpyrazoles and Related Compounds via Regioselective C-H Bond Cleavage

Nobuyoshi Umeda et al.

JOURNAL OF ORGANIC CHEMISTRY (2009)

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Rh-Catalyzed C-H Functionalization of the (Pyrazol-5-yl)pyridine Core of GBT-440

相关参考文献

Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins br

First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer

Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds

Rhodium-Catalyzed Mono- and Divinylation of 1-Phenylpyrazoles and Related Compounds via Regioselective C-H Bond Cleavage

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