Synthesis and Optical Resolution of Inherently Chiral Fluorescent Calix[4]arenes and Their Application in Chiral Recognition

Inherently chiral calix[4]arenes were separated by condensation with chiral auxiliary (S)-and (R)-1-phenylethylamine using column chromatography on silica gel; subsequent derivatization with click chemistry furnished compounds with fluorescent properties that can be used for chiral recognition.

Automated summary

Inherently chiral calix[4]arenes were separated by condensation with chiral auxiliary (S)-and (R)-1-phenylethylamine using column chromatography on silica gel; subsequent derivatization with click chemistry resulted in compounds with fluorescent properties that can be used for chiral recognition.