Nickel-Catalyzed Asymmetric Arylation of H-Phosphinates

An asymmetric arylation of H-phosphinates with aromatic iodo or bromo compounds, catalyzed by cheap and easily available nick-el(II) salts, provides access to P-stereogenic phosphinates. This method features mild reaction conditions and a good functional-group compat-ibility that includes aniline and phenol derivatives.

Automated summary

An asymmetric arylation of H-phosphinates with aromatic iodo or bromo compounds, catalyzed by cheap and easily available nickel(II) salts, allows the synthesis of P-stereogenic phosphinates. This method offers mild reaction conditions and good functional-group compatibility including aniline and phenol derivatives.