Br circle divide nsted Acid Catalyzed Asymmetric Silylation of Biaryl Diols

We report a Br circle divide nsted acid catalyzed enantioselective silylation of biaryl diols with an allylsilane as a silicon source. This process enables facile access to enantioenriched biaryl silyl ethers with an axial stereogenicity. A control experiment supports a mechanism proceeding by desymmetrization followed by kinetic resolution.

Automated summary

We describe a Brønsted acid-catalyzed enantioselective silylation of biaryl diols using an allylsilane as a source of silicon. This method allows for easy access to enantioenriched biaryl silyl ethers with axial stereogenicity. A control experiment confirms a mechanism involving desymmetrization followed by kinetic resolution.