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Enantioselective Formal Synthesis of (-)-Catharanthine through Enzyme-Catalyzed Desymmetrization of a meso -Azabicyclo [2.2.2]octane

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Summary: This study reported a catalytic approach for the formal synthesis of more than 20 types of sarpagine/macroline alkaloids, with two key steps being the amide insertion reaction using cheap copper and biocatalytic asymmetric desymmetrization.

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Total Synthesis of Lyconesidine B, a Lycopodium Alkaloid with an Oxygenated, Amine-Type Fawcettimine Core

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Summary: This report describes the total synthesis of the complex, oxygenated tetracyclic alkaloid, lyconesidine B. Key challenges include the diastereoselective generation of a decahydroquinoline ring and the domino ene-yne metathesis, both crucial steps in the synthesis process.

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Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine

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Ibogan, Tacaman, and Cytotoxic Bisindole Alkaloids from Tabernaemontana. Cononusine, an Iboga Alkaloid with Unusual Incorporation of a Pyrrolidone Moiety

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Article Chemistry, Multidisciplinary

Formal synthesis of (+)-catharanthine

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

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Enantioselective Formal Synthesis of (-)-Catharanthine through Enzyme-Catalyzed Desymmetrization of a meso -Azabicyclo [2.2.2]octane

相关参考文献

Merging Chemo- and Biocatalysis to Facilitate the Syntheses of Complex Natural Products: Enantioselective Construction of an N-Bridged [3.3.1] Ring System in Indole Terpenoids

Total Synthesis of Lyconesidine B, a Lycopodium Alkaloid with an Oxygenated, Amine-Type Fawcettimine Core

Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine

Ibogan, Tacaman, and Cytotoxic Bisindole Alkaloids from Tabernaemontana. Cononusine, an Iboga Alkaloid with Unusual Incorporation of a Pyrrolidone Moiety

Pig liver esterase (PLE) as biocatalyst in organic synthesis:: From nature to cloning and to practical applications

Formal synthesis of (+)-catharanthine

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