期刊
SYNLETT
卷 34, 期 11, 页码 1241-1246出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-2030-7826
关键词
photoredox catalysis; heteroarenes; ketone; C-C bond cleavage; alkylation
We present a metal-free visible-light-mediated C(sp(2))-H alkylation of N-heteroarenes with dihydroquinazolines derived from aliphatic ketones under oxidative conditions. This strategy enables the construction of C-C bonds through a Minisci-type reaction, activating the native C-H bond of the N-heteroarene and an α-C-C bond of a readily available ketone. The versatility of this mild method allows for the use of various N-heteroarenes and ketones, with tolerance towards a broad range of functional groups.
We report a visible-light-mediated, organophotoredox-catalyzed, C(sp(2))-H alkylation of N-heteroarenes with dihydroquinazolines, prepared from aliphatic ketones, under oxidative conditions. This protocol represents a metal-free approach to the effective construction of C-C bonds through a Minisci-type reaction, formally activating the native C-H bond of the N-heteroarene and an a-C-C bond of a readily available ketone. The mild nature of this method accommodates a wide variety of N-heteroarenes and ketones, tolerating a wide range of functional groups.
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